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Cat. No. | Product Name | Target | Signaling Pathways |
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TP1647 |
β-Endorphin, equine
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Endorphin Beta is A substance produced in the brain, especially in the pituitary gland, Endorphin Beta blocks the sensation of pain. Endorphin Beta is produced in response to pain, exercise, and other forms of stress. Endorphin Beta belongs to a group of | |||
TP1391 |
β-Endorphin, equine (TFA)
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β-Endorphin, equine (TFA) is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors. | |||
T1172 |
Diclazuril
地克珠利,R-64433 |
Antibiotic; Parasite | Microbiology/Virology |
Diclazuril (R-64433) 是一种具有口服活性的抗球虫剂,是苯乙腈衍生物。它可用于某些传染病和寄生虫病的相关研究。 | |||
T21900 |
ML-336
(E)-2-((1,4-二甲基哌嗪-2-亚基)氨基)-5-硝基-N-苯基苯甲酰胺 |
Others | Others |
ML-336 是一种喹唑啉酮类的委内瑞拉马脑炎病毒 (VEEV) 抑制剂,其VEEV TC-83 CPE(IC50:32 nM)、VEEV V3526 CPE(IC50:20 nM)、VEEV 野生型 CPE (IC50:42 nM),有效抑制 VEEV 诱导的三种病毒株 (V3526、TC-83和野生型) 细胞病变效应。 | |||
T8498 |
EIDD-1931
Beta-d-N4-hydroxycytidine |
Virus Protease; HCV Protease; SARS-CoV; Topoisomerase | DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
EIDD-1931 (Beta-d-N4-hydroxycytidine) 是一种核苷类抗病毒试剂 ,可抑制丙型肝炎病毒、基孔肯亚病毒和委内瑞拉马脑炎病毒的复制活性。 | |||
T36021 |
Flumequine-13C3
Flumequine-13C3 |
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Flumequine-13C3is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine is a fluoroquinolone antibiotic.1It is active againstS. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, andK. pneumoniae(MICs = 1-100 μg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 μg/ml).2It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication.3In vivo, fl... | |||
T1060 |
Flumequine
Flumigal,氟甲喹,R-802 |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Flumequine (R-802) 是一种喹诺酮类抗生素,对革兰氏阳性菌和革兰氏阴性菌均有效。它是拓扑异构酶 II 抑制剂, 抑制细胞分裂,IC50值为 15 μM (3.92 μg/mL)。 | |||
T19897 |
Anavenol
2-(2-萘氧基)乙醇,2-(naphthalen-2-yloxy)ethanol |
Others | Others |
Anavenol (2-(naphthalen-2-yloxy)ethanol) 是一种马麻醉剂。 | |||
T63218 | Encephalitic alphavirus-IN-1 | ||
Encephalitic alphavirus-IN-1 能够抑制委内瑞拉马脑炎病毒 (VEEV) (EC50: 0.24 μM)和东部马脑炎病毒 (EEEV) (EC50: 0.16 μM)的活性。Encephalitic alphavirus-IN-1 没有明显的细胞毒性,而且表现出较强的小鼠血浆稳定性。 | |||
T19776 |
Equilenin
Equilenine,E 400,NSC 9901,d-Equilenin |
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Equilenin is an equine estrogen found in the urine of pregnant mares. It is also a naturally fluorescent steroid, has a high binding affinity for human sex steroid-binding protein (SBP). | |||
T61399 |
Z164597606
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Z164597606 is a compound that acts as a selective inhibitor of the enzyme Butyrylcholinesterase (BChE), with IC50 values of 1.3 μM and 1.7 μM for equine BChE and human BChE, respectively. Through a π-π stacking interaction, Z164597606 specifically interacts with the amino acid Trp82 of human BChE. This compound has potential applications in Alzheimer's disease research [1] [2]. | |||
T60529 |
AChE/BChE-IN-3
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AChE/BChE-IN-3 (BMC-1) 是AChE 和BChE 的双重抑制剂,对电鳗 AChE (elAChE) 的IC50值为 6.08 μM ,对马血清 BChE (eqBChE) 的IC50值为 0.383 μM。 | |||
T36880 |
NHC-diphosphate
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NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV)[1]. Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and ... | |||
T60831 | AChE/BChE-IN-3 hydrochloride | ||
AChE/BChE-IN-3 (BMC-1) hydrochloride 是 AChE 和 BChE 的双重抑制剂。AChE/BChE-IN-3 对马血清 BChE (eqBChE) 和电鳗 AChE (elAChE) 的 IC50值分别为 0.383 μM 和 6.08 μM。 | |||
T79502 |
PD24
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PD24是AChE和BuChE的抑制剂,表现出一定的抑制效力(hAChE IC50: 1.72 μM;eeAChE IC50: 1.76 μM;eqBuChE IC50: 2.64 μM)。该化合物还具备抗氧化性能,能有效抑制DPPH自由基(IC50: 28.72 μM)。因此,PD24适用于阿尔茨海默病相关的研究。 | |||
T39678 | Multitarget AD inhibitor-1 | ||
Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM and 1.55 μM for human BuChE (hBuChE) and equine serum BuChE (eqBuChE), respectively. Additionally, it exhibits inhibitory activity towards β-secretase (IC50 value of 41.60 μM), amyloid β aggregation (IC50 value of 3.09 μM), and tau aggregation. As a diphenylpropylamine derivative, Multitarget AD inhibitor-1 holds promise for research pertaining to the multifunctional, d... | |||
T79423 |
BuChE-IN-9
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BuChE-IN-9 (compound 22a) 作为eqBuChE的抑制剂,表现出相当的效力,具有173 nM的IC50值。除此之外,BuChE-IN-9对人BACE1、Aβ聚集及小鼠mGAT1和mGAT4也具有抑制作用,并且显示出显著的抗遗忘特性。 | |||
T79501 |
PD10
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PD10为同时针对AChE与BuChE的抑制剂,在人脑AChE (hAChE IC50: 0.56 μM)、电鳗AChE (eeAChE IC50: 0.59 μM)、马血清BuChE (eqBuChE IC50: 1.06 μM) 均有显著抑制效果,适用于阿尔茨海默病相关研究。 | |||
T61994 | AChE/BChE-IN-8 | ||
AChE/BChE-IN-8 (Compound 5a) 是非竞争性AChE 抑制剂和混合型BChE 抑制剂。AChE/BChE-IN-8抑制电鳗 AChE (EeAChE) 和马 BChE (eqBChE) 的Ki 值分别为 0.788 μM 和 2.364 μM。AChE/BChE-IN-8 具有血脑屏障通透性和低细胞毒性。 | |||
T78905 |
AChE-IN-29
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AChE-IN-29,是一款3-OH 吡咯烷衍生的胆碱酯酶 (ChE) 抑制剂。针对hAChE、eeAChE及eqBChE的抑制活性表现出的IC50值分别为0.25 μM、0.23 μM和0.72 μM,可作为阿尔茨海默病研究中的实验化合物。 | |||
T73187 |
BuChE-IN-7
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BuChE-IN-7 是一种 hBuChe 和 eqBuChE 的高选择性抑制剂,IC50分别为 40 nM、80 nM。BuChE-IN-7 能透过血脑屏障促进认知,改善了情境性与恐惧性记忆,表现出对新事物的偏好。 | |||
T71288 |
Phenylbutazone-d9
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Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide). It also inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-in... | |||
T71984 |
Enrofloxacin-d5
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Enrofloxacin-d5 is intended for use as an internal standard for the quantification of enrofloxacin by GC- or LC-MS. Enrofloxacin is a fluoroquinolone antibiotic. It is active against panels of Campylobacter, E. coli, and Salmonella isolates (mean MIC50s = 0.06, 0.5, and 0.03 µg/ml, respectively). It is also active against equine isolates of L. intracellularis (MICs = 0.125-0.5 µg/ml). Enrofloxacin inhibits bacterial DNA gyrase. In vivo, enrofloxacin (10 mg/kg) increases survival in a mouse model... | |||
T79342 | BChE-IN-17 | ||
BChE-IN-17(compound 6n)是一种高效的BChE选择性抑制剂,对eqBChE和hBChE的IC50值为10.5 nM和32.5 nM。与AChE相比,其对BChE的选择性提高了1000倍,且表现出较低的神经毒性和中等程度的神经保护效果。 | |||
T37492 |
11-trans Leukotriene C4
11-trans Leukotriene C4 |
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11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum ... | |||
T62441 |
AChE-IN-14
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AChE-IN-14 是一种有效的胆碱酯酶抑制剂,能够作用于电鳗乙酰胆碱酯酶 (eeAChE) (IC50: 0.46 μM)、人重组乙酰胆碱酯酶 (hAChE) (IC50: 0.48 μM) 和马血清丁酰胆碱酯酶 (eqBuChE) (IC50: 0.44 μM)。AChE-IN-14 对人 H3 受体 (H3R) 的亲和力高 (Ki: 159.8 nM)。AChE-IN-14 能够用于研究阿尔茨海默病。 | |||
T38161 |
STING Agonist C11
STING Agonist C11 |
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STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses gro... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T76027 |
β-Endorphin, equine TFA
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β-Endorphin, equine TFA,是具备强效亲和力于μ和δ阿片受体(μ/δ opioid receptors)的内源性阿片类多肽,主要功能包括止痛。 | |||
T35779 |
Oosporein
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Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ... |