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26

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1564	Cisplatin cis-Diaminodichloroplatinum,CDDP,顺铂	DNA Alkylator/Crosslinker; Ferroptosis; DNA/RNA Synthesis; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cisplatin (CDDP) 是一种 DNA 交联剂。Cisplatin 具有抗肿瘤活性，能够通过在癌细胞中形成 DNA 加合物来抑制 DNA 合成。Cisplatin 还可激活铁死亡并诱导自噬。
T19106	2-(Pyridyldithio)ethylamine hydrochloride 2-(2-吡啶基二硫基)乙胺盐酸盐,(S)-2-Pyridylthio Cysteamine Hydrochloride	Others	Others
	2-(Pyridyldithio)ethylamine hydrochloride ((S)-2-Pyridylthio Cysteamine Hydrochloride) 是新型的二硫化物插入交联剂。
T1224	Cefuroxime sodium Anaptivan,头孢呋辛钠,Cefuroxime sodium salt,Biociclin	Antibacterial; Antibiotic	Microbiology/Virology
	Cefuroxime sodium (Cefuroxime sodium salt) 是一种具有口服活性的头孢菌素抗生素，增加了对 β-内酰胺酶的稳定性。
T0164	Oxaliplatin L-OHP,奥沙利铂	DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Oxaliplatin (L-OHP) 是一种 DNA 烷化剂，一种 DNA 合成抑制剂。Oxaliplatin 会导致 DNA 交联损伤，阻止 DNA 复制和转录并导致细胞死亡。Oxaliplatin 可以诱导细胞自噬。
T14298	Rimiducid	Apoptosis; Others; Fatty Acid Synthase	Apoptosis; Metabolism; Others
	Rimiducid 是一种可渗透脂质的他克莫司类似物，是一种二聚剂，通过交联 FKBP 结构域起作用。它将 Caspase 9 自杀开关二聚化并迅速诱导细胞凋亡。
T78362	Transglutaminase TG
	Transglutaminase (TG) 是一种硫醇酶，促使蛋白质分子间交联，通过催化谷氨酰胺残基的γ-羧酰胺基团与其他化合物的一级ε-胺基团形成异肽键。该酶在包括凝血、抗菌免疫反应和光合作用在内的多种生理过程中发挥作用。
T5022	Ceforanide	Antibacterial; Antibiotic	Microbiology/Virology
	Ceforanide 是一种头孢菌素，可静脉或肌肉给药。它在体外具有一系列抗菌活性。
T21306	Glyfosfin
	Glyfosfin is a DNA cross-linking agent and an alkylating agent with anticancer activity.
T32206	Isodityrosine
	Isodityrosine is a new cross-linking amino acid from plant cell-wall glycoprotein.
T16890	SJG-136 NSC-694501	Others	Others
	SJG-136 is a DNA cross-linking agent (XL50: 45 nM for pBR322 DNA).
T35271	Yoshi-864 Yoshi864,Improsulfan HCl,NSC102627,Improsulfan hydrochloride
	Yoshi-864 alkylates and cross-links DNA, thereby inhibiting DNA replication. It is an alkyl sulfonate DNA cross-linking agent with potential anti-cancer activity.
T41026	Biotin-LC-LC-NHS
	Biotin-LC-LC-NHS is a SMCC cross-linking reagent, which serves as a labeling agent for antibodies and small molecules, like Paclitaxel.
T19944	DSSeb Crosslinker DSSeb Cross linker,DSSeb Cross-linker
	DSSeb Crosslinker is a homobifunctional cross-linking reagent. It is useful in protein crosslinking and making antibody-drug conjugates.
T40642	Chlorpyrifos-oxon
	Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a powerful phosphorylating agent with potent inhibition of AChE activity. It induces cross-linking between tubulin subunits and disrupts microtubule function[4].
T19568	Sulfo-SMPB sodium	Others	Others
	Sulfo-SMPB sodium is a non-cleavable heterobifunctional chemical cross-linking reagent that combines N-hydroxysuccinimide ester and maleimide groups. This compound enables the covalent conjugation of molecules possessing amine and sulfhydryl functionalities.
T19945	N,N'-Carbonyldiimidazole 1,1'-Carbonyldiimidazole,N,N'-Carbonyldiimidazole,CDI Crosslinker	Others	Others
	N,N'-Carbonyldiimidazole 是一种生物交联剂，在质谱检测化合物纯度上有很大的应用。
T19203	Bendamustine D4 SDX-105 D4	Others	Others
	Bendamustine D4 is the deuterium-labeled Bendamustine. Bendamustine is a DNA cross-linking compound with alkylating and antimetabolite properties. Bendamustine causes DNA breaks.
T38765	UBE2T/FANCL-IN-1 UBE2T/FANCL-IN-1
	UBE2T/FANCL-IN-1 is a highly effective inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation. It greatly enhances the sensitivity of cells to Carboplatin, a DNA cross-linking agent.
T40947	PR-104 sodium
	PR-104 sodium is a hypoxia-activated DNA cross-linking agent used in the research of tumor xenograft models. It functions as a nitrogen mustard pre-prodrug and efficiently transforms into the more lipophilic dinitrobenzamide mustards alcohol PR-104A.
T71034	Bizelesin
	Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis.
T82466	Englumafusp alfa RG6076,CD19-4-1BBL,RO7227166
	Englumafusp alfa (CD19-4-1BBL; RO7227166)是一款由CD19特异性抗体域与人41BBL的三聚体胞外域结合构成的融合蛋白。该化合物能够促进T细胞与NK细胞表面CD19特异性4-1BB的交联作用。
T69873	Cefdinir monohydrate
	Cefdinir monohydrate is the salt form of Cefdinir (free base), a semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefdinir's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidog...
T81773	Modotuximab Sym 004,DS 1024
	Modotuximab (Anti-HumanEGFRRecombinant Antibody) 是一种IgG1κ型嵌合抗体，靶向人源EGFR蛋白。由Futuximab部分构成，Modotuximab能同时结合EGFR上两个独立非重叠的表位。该抗体通过促进EGFR在细胞表面的交联，并加速EGFR的细胞内化与降解，展现出体内的抗肿瘤活性。
T35646	4-oxo-2-Nonenal 4-oxo-2-Nonenal,4-ONE
	4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid. [1] [2] It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.[1][2][3] 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.[4][5][6] It actively modifies histidine and lysine residues on prot...
T62582	WEHI-150
	WEHI-150是一种米托蒽醌类似物，作为DNA链间交联剂，具有12.5小时的半衰期。该化合物能够在CpG序列上形成共价加合物，对甲基化CpG位点表现出选择性。甲醛激活的WEHI-150能够诱导DNA链间交联，并表现出浓度依赖性的转录阻断作用。此外，WEHI-150还能在新的DNA序列中形成加合物，这不涉及与鸟嘌呤N-2的相互作用。
T60438	PXS-6302
	PXS-6302 是不可逆的赖氨酸氧化酶 (LOX) 抑制剂，对Bovine LOX、rh LOXL1、rh LOXL2、rh LOXL3、rh LOXL4的IC50分别为 3.7 μM，3.4 μM，0.4 μM，1.5 μM 和0.3 μM。PXS-6302 可以轻松渗透皮肤，减少胶原蛋白沉积和交联，显着改善疤痕外观而不降低组织强度。 PXS-6302 在其他纤维化疾病中也可能有更广泛的应用。

化合物

Cat.No: T1564

Synonym: cis-Diaminodichloroplatinum,CDDP,顺铂

Target: DNA Alkylator/Crosslinker, Ferroptosis, DNA/RNA Synthesis, Autophagy

2-(Pyridyldithio)ethylamine hydrochloride

Cat.No: T19106

Synonym: 2-(2-吡啶基二硫基)乙胺盐酸盐,(S)-2-Pyridylthio Cysteamine Hydrochloride

Target: Others

Cefuroxime sodium

Cat.No: T1224

Synonym: Anaptivan,头孢呋辛钠,Cefuroxime sodium salt,Biociclin

Target: Antibacterial, Antibiotic

Cat.No: T0164

Synonym: L-OHP,奥沙利铂

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy

Cat.No: T14298

Target: Apoptosis, Others, Fatty Acid Synthase

Transglutaminase

Cat.No: T78362

Synonym: TG

Cat.No: T5022

Target: Antibacterial, Antibiotic

Cat.No: T21306

Cat.No: T32206

Cat.No: T16890

Synonym: NSC-694501

Target: Others

Cat.No: T35271

Synonym: Yoshi864,Improsulfan HCl,NSC102627,Improsulfan hydrochloride

Biotin-LC-LC-NHS

Cat.No: T41026

DSSeb Crosslinker

Cat.No: T19944

Synonym: DSSeb Cross linker,DSSeb Cross-linker

Chlorpyrifos-oxon

Cat.No: T40642

Sulfo-SMPB sodium

Cat.No: T19568

Target: Others

N,N'-Carbonyldiimidazole

Cat.No: T19945

Synonym: 1,1'-Carbonyldiimidazole,N,N'-Carbonyldiimidazole,CDI Crosslinker

Target: Others

Bendamustine D4

Cat.No: T19203

Synonym: SDX-105 D4

Target: Others

UBE2T/FANCL-IN-1

Cat.No: T38765

Synonym: UBE2T/FANCL-IN-1

Cat.No: T40947

Cat.No: T71034

Englumafusp alfa

Cat.No: T82466

Synonym: RG6076,CD19-4-1BBL,RO7227166

Cefdinir monohydrate

Cat.No: T69873

Cat.No: T81773

Synonym: Sym 004,DS 1024

4-oxo-2-Nonenal

Cat.No: T35646

Synonym: 4-oxo-2-Nonenal,4-ONE

Cat.No: T62582

Cat.No: T60438

Cat. No.	Product Name	Target	Signaling Pathways
TN4345	Jacobine	Others	Others
	Jacobine induces significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. It was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments.

天然产物

Cat.No: TN4345

Target: Others

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