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3

抑制剂 & 化合物

2

天然产物

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Cat. No. Product Name Target Signaling Pathways
T1623 Lopinavir

ABT-378,洛匹那韦

SARS-CoV; HIV Protease Microbiology/Virology; Proteases/Proteasome
Lopinavir (ABT-378) 是一种选择性肽模拟 HIV-1 蛋白酶的高效抑制剂。它通过阻止 HIV-1 的成熟而起作用,从而阻断其感染性。它也是 SARS-CoV 3CLpro 的抑制剂。
T31899 FY26

FY 26,FY-26

FY26 is a potent Os(II) anticancer drug candidate, exerts its activity by generating reactive oxygen species and disrupting the redox balance in cancer cells Coadministration of FY26 and nontoxic doses of L-BSO allows the potentiation of its anticancer ac
T69956 KR30031

KR30031 is a novel P-glycoprotein inhibitor with potential anticancer activity. KR30031 is a verapamil analog with fewer cardiovascular effects. The ability of KR-30031 to reduce this efflux transport is equal to that of verapamil, a well-known P-glycoprotein inhibitor. The bioavailability of paclitaxel could be enhanced by coadministration of a P-glycoprotein inhibitor, KR-30031.

化合物

Lopinavir
Cat.No: T1623
Synonym: ABT-378,洛匹那韦
Target: SARS-CoV, HIV Protease
FY26
Cat.No: T31899
Synonym: FY 26,FY-26
Target:
KR30031
Cat.No: T69956
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN4761 Phellamurin

P-gp Membrane transporter/Ion channel; Neuroscience
Phellamurin 是一种来自黄檗叶的黄酮糖苷,可诱导细胞凋亡,具有抗肿瘤活性。它抑制肠道 P-糖蛋白,还抑制凤蝶的产卵。
T3824 Jaceosidin

Apoptosis; BCL; COX; UGT Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。

天然产物

Phellamurin
Cat.No: TN4761
Synonym:
Target: P-gp
Jaceosidin
Cat.No: T3824
Synonym:
Target: Apoptosis, BCL, COX, UGT
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