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12

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22419	S-Methylisothiourea sulfate (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐	NOS; NO Synthase; HSV	Immunology/Inflammation; Microbiology/Virology
	S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂，在感染性休克的啮齿动物模型中发挥有益作用。
T10498	5-HT2A antagonist 1	5-HT Receptor	GPCR/G Protein; Neuroscience
	5-HT2A antagonist 1 is a 5-HT2A antagonist. It may be useful in the treatment of gastrointestinal disorders circulatory disorders.
T69150	Anisodine
	Anisodine, also known as Daturamine, is an antispasmodic and anticholinergic drug used in the treatment of acute circulatory shock. Anisodine acts as a muscarinic acetylcholine receptor antagonist and α1-adrenergic receptor agonist.
T40550	Human β-defensin-1 Human β-defensin-1,HβD-1
	Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by epithelial surfaces, circulatory cells, and cells of the reproductive tract. It exhibits antimicrobial activity against a wide range of sperm bacteria.
T6663	Scopine hydrochloride 盐酸东莨菪醇,Scopine HCl,6,7-Epoxytropine hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Scopine hydrochloride (6,7-Epoxytropine hydrochloride) 是一种 Anisodine 的代谢物。
T25728	Limaprost alfadex Opalmon,OP 1306 - alpha-cyclodextrin,Prorenal
	Limaprost alfadex is an oral medicine for the circulatory system (for confinement-related thromboangiitis ulcer, anaphrodisia, sharp pain and ischemia characteristics symptom, the improvement of subjective symptom and walking ability with postnatal lumbar
T22572	Angiotensin 1/2 (1-7) amide	Others	Others
	Angiotensin I/II (1-7) amide is a peptide analog to angiotensin II that is used as a vasopressor in the treatment of certain types of shock and circulatory collapse. Angiotensin I/II amide is an amide derivative of angiotensin II that is a powerful vasoco
TP2220	Angiotensin 1/2 (1-8) amide	Others	Others
	Angiotensin 1/2 (1-8) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-amide) is a peptide analog to angiotensin II that is used as a vasopressor agent in the treatment of certain types of shock and circulatory collapse. It is a potent vasoconstrictor and is us
T61027	Piribedil hydrochloride
	Piribedil hydrochloride 可用于帕金森病，循环系统疾病，癌症等的研究。Piribedil hydrochloride 以0.18 μM 的EC50值抑制 MLL1 甲基转移酶的活性。Piribedil hydrochloride 是口服有效的多巴胺 D2 和多巴胺 D3 激动剂，也是 α2-肾上腺素能受体的拮抗剂。
T80528	Ssm spooky toxin SsTx Toxin	Potassium Channel	Membrane transporter/Ion channel
	Ssm Spooky Toxin是从Scolopendra mutilans中分离出的化合物，其特点是有效抑制KCNQ（电压门控钾通道家族7）通道，表现出对血液和呼吸系统的致命毒性。Ssm Spooky Toxin对Kv7.4、Kv1.3和Shal通道的IC50值分别为2.8 μM、5.26 μM和0.1-0.3 M，且能够通过针对T细胞中的KV1.3通道抑制细胞因子的产生，在蜈蚣的循环系统中起着关键作用。
TP2221	ANP (1-11), rat	Others	Others
	Atrial Natriuretic Peptide (ANP) has the sequence of H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-OH, is a 28 amino acid peptide. ANP is a powerful vasodilator, and a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the hom
T36766	Palmitoylcholine (chloride)
	Palmitoylcholine is an acyl choline.1It inhibits protein kinase C activity when used at a concentration of 100 μM.2Palmitoylcholine induces hemolysis in rat erythrocytes.3Plasma levels of palmitoylcholine are decreased in female patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).1 1.Germain, A., Barupal, D.K., Levine, S.M., et al.Comprehensive circulatory metabolomics in ME/CFS reveals disrupted metabolism of acyl lipids and steroidsMetabolites10(1)34(2020) 2.Nakadate, T.,...

化合物

S-Methylisothiourea sulfate

Cat.No: T22419

Synonym: (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐

Target: NOS, NO Synthase, HSV

5-HT2A antagonist 1

Cat.No: T10498

Target: 5-HT Receptor

Cat.No: T69150

Human β-defensin-1

Cat.No: T40550

Synonym: Human β-defensin-1,HβD-1

Scopine hydrochloride

Cat.No: T6663

Synonym: 盐酸东莨菪醇,Scopine HCl,6,7-Epoxytropine hydrochloride

Target: Adrenergic Receptor

Limaprost alfadex

Cat.No: T25728

Synonym: Opalmon,OP 1306 - alpha-cyclodextrin,Prorenal

Angiotensin 1/2 (1-7) amide

Cat.No: T22572

Target: Others

Angiotensin 1/2 (1-8) amide

Cat.No: TP2220

Target: Others

Piribedil hydrochloride

Cat.No: T61027

Ssm spooky toxin

Cat.No: T80528

Synonym: SsTx Toxin

Target: Potassium Channel

ANP (1-11), rat

Cat.No: TP2221

Target: Others

Palmitoylcholine (chloride)

Cat.No: T36766

Cat. No.	Product Name	Target	Signaling Pathways
T8304	Anisodamine Hydrobromide 6-Hydroxyhyoscyamine,氢溴酸山莨菪碱	Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	Anisodamine Hydrobromide (6-Hydroxyhyoscyamine) 是来自颠茄的一种生物碱，具有抗氧化、抗炎活性。它也是一种非亚型的选择性毒蕈碱和烟碱类胆碱受体拮抗剂。
T0970	Racanisodamine 山莨菪碱,Anisodamine,7β-Hydroxyhyoscyamine,Raceanisodamine,消旋山莨菪碱	Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	Racanisodamine (7β-Hydroxyhyoscyamine) 是 anisodamine 的消旋体，是非选择性的毒蕈碱拮抗剂，是近视控制滴眼液的有效成分。
T6662	Scopine 东莨菪醇,6,7-Epoxytropine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Scopine (6,7-Epoxytropine) 是一种山莨菪碱的代谢物，是一种 α1-肾上腺素受体激动剂，用于治疗急性循环性休克。
T1287	Synephrine 辛弗林,Oxedrine	Endogenous Metabolite; Adrenergic Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Synephrine (Oxedrine) 是来自 Citrus aurantium 的α-adrenergic 和β-adrenergic 激动剂，是一种生物碱。它也是一种拟交感神经化合物，能够用于减肥。
T73925	α-D-Glucose-1-phosphate disodium hydrate
	α-D-Glucose-1-phosphate disodium hydrate 为合成葡萄糖醛酸的初始原料之一，同时，在心脏病研究领域，亦被广泛应用作为细胞抑制剂、抗生素、免疫抑制剂与循环系统研究的关键材料。

天然产物

Anisodamine Hydrobromide

Cat.No: T8304

Synonym: 6-Hydroxyhyoscyamine,氢溴酸山莨菪碱

Target: Adrenergic Receptor, AChR

Cat.No: T0970

Synonym: 山莨菪碱,Anisodamine,7β-Hydroxyhyoscyamine,Raceanisodamine,消旋山莨菪碱

Target: Adrenergic Receptor, AChR

Cat.No: T6662

Synonym: 东莨菪醇,6,7-Epoxytropine

Target: Adrenergic Receptor

Cat.No: T1287

Synonym: 辛弗林,Oxedrine

Target: Endogenous Metabolite, Adrenergic Receptor

α-D-Glucose-1-phosphate disodium hydrate

Cat.No: T73925

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