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Targets Recommended: IκB/IKK

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T22021	ACHP IKK-2 Inhibitor VIII	IκB/IKK	NF-κB
	ACHP(IKK-2 Inhibitor VIII) 是一种新型具有选择性和高效性的 IKK 抑制剂，对IKK-α和IKK-β 具有抑制作用。ACHP 具有抗 HIV-1 活性，通过抑制 NF-κB 激活来抑制 HIV-1 长末端重复序列（LTR）驱动的基因表达，抑制 TNF-α 诱导的 NF-κB （p65）募集到 HIV-1 LTR。
T10809L	CHPG hydrochloride CHPG hydrochloride(170846-74-9 Free base)	ERK; NF-κB; GluR	MAPK; Neuroscience; NF-κB
	CHPG hydrochloride 是 mGluR5 的选择性激动剂。
T10237	ACHP Hydrochloride IKK-2 Inhibitor VIII	IκB/IKK	NF-κB
	ACHP Hydrochloride (IKK-2 Inhibitor VIII) 是选择性的IKK-β抑制剂 (IC50=5.8 nM)。
T10808	CHPG sodium salt	NF-κB; GluR	Neuroscience; NF-κB
	CHPG sodium salt 是 mGluR5 的选择性激动剂，可激活 ERK 和 Akt 信号通路。 CHPG 钠盐可用于创伤性脑损伤的研究。
T10809	CHPG	Others	Others
	CHPG is a selective agonist of mGluR5. In BV2 microglial cells, it attenuates SO2-induced oxidative stress and inflammation through the TSG-6/NF-κB pathway.
T77651	Tubulin polymerization-IN-47	Microtubule Associated	Cytoskeletal Signaling
	Tubulin polymerization-IN-47 是一种 tubulin 聚合抑制剂和有丝分裂抑制剂，具有抗肿瘤活性，对神经母细胞瘤癌细胞增殖具有抑制作用，对 Chp-134 和 Kelly 细胞系的IC50 分别为 7 和 12 nM。Tubulin polymerization-IN-47 是治疗肝癌、结肠癌、肺癌和乳腺癌的候选化合物。
T79645	Tubulin polymerization-IN-48
	Tubulin polymerization-IN-48 (Compound 4k) 是一种中等强度破坏微管网络的微管蛋白聚合抑制剂。其对神经母细胞瘤癌细胞增殖的抑制效果显著，Chp-134 细胞系和 Kelly 细胞系的IC50值分别为79 nM和165 nM。
T35599	Neuropeptide Y (3-36) (human, rat) (trifluoroacetate salt)
	Neuropeptide Y (NPY) (3-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion. NPY (3-36) is an endogenous peptide produced by cleavage of NPY by dipeptidyl peptidase 4 (DPP-4). It binds selectively to the NPY receptor Y2 (Ki = 0.41 nM in CHP 234 cells) over the Y1 receptor, where it does not bind at concentrations up to 1 μM. NPY (3-36) (0.1 nM) increases migration of human umbilical vein endothelial...

化合物

ACHP

Cat.No: T22021

Synonym: IKK-2 Inhibitor VIII

Target: IκB/IKK

CHPG hydrochloride

Cat.No: T10809L

Synonym: CHPG hydrochloride(170846-74-9 Free base)

Target: ERK, NF-κB, GluR

ACHP Hydrochloride

Cat.No: T10237

Synonym: IKK-2 Inhibitor VIII

Target: NF-κB, GluR

Tubulin polymerization-IN-47

Cat.No: T77651

Synonym:

Target: Microtubule Associated

Tubulin polymerization-IN-48

Cat.No: T79645

Synonym:

Target:

Neuropeptide Y (3-36) (human, rat) (trifluoroacetate salt)

Cat.No: T35599

Synonym:

Target:

Species：

Expression System：

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Cat. No.	Product Name	Species	Expression System
TMPH-03529	Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His) CHIPS,Chemotaxis inhibitory protein,chp	Staphylococcus aureus	P. pastoris (Yeast)
	Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Re...
TMPH-03528	Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS47), Recombinant (His & Myc) chp,Chemotaxis inhibitory protein,CHIPS	Staphylococcus aureus	E. coli
	Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS...

重组蛋白

Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His)

Cat.No: TMPH-03529

Species: Staphylococcus aureus

Expression System: P. pastoris (Yeast)

Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS47), Recombinant (His & Myc)

Cat.No: TMPH-03528

Species: Staphylococcus aureus

Expression System: E. coli

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