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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2046	Nimorazole Nimorazol,Nitrimidazine,尼莫唑,K-1900,Naxogin,尼莫拉唑	Others; Antibiotic; Parasite	Microbiology/Virology; Others
	Nimorazole (Nimorazol) 是一种 2-硝基咪唑，是一种低氧细胞辐射敏化剂。它具有抗感染，抗滴虫等原生动物的作用。它有头颈癌的研究潜力。
T2020	RGW 611	Others	Others
	RGW 611 是一种能够增强辐射且诱导缺氧 V79-379A 细胞死亡的吗啉衍生物。
T6970	RK33 RK-33,RK 33	COX	Immunology/Inflammation; Neuroscience
	RK33 (RK 33) 是 DDX3（一种 RNA 解旋酶）的一流小分子抑制剂，可导致 G1 细胞周期停滞，诱导细胞凋亡，并促进 DDX3 过表达细胞的辐射增敏。
T2386	Pirfenidone S-7701,AMR-69,S-7701,AMR69,吡非尼酮	CCR; TGF-beta/Smad	Immunology/Inflammation; Microbiology/Virology; Stem Cells
	Pirfenidone (AMR69) 是一种抗纤维化剂，可减弱纤维细胞中CCL2和CCL12的产生。它可抑制细胞生长，并能降低人胶质瘤细胞系中的TGF-β2蛋白水平，具有抗炎活性。
T22070	DBIBB	LPA Receptor	GPCR/G Protein
	DBIBB 是一种特异性溶血磷脂酸 (LPA2) 的 2 型 G 蛋白偶联受体的非脂质激动剂，是一种能够治疗高强度γ 射线对造血和胃肠系统引起的急性放射综合征的潜在活性分子，是一种作未有机合成和药物研究中的中间体。 DBIBB 可用于制备各种化合物，可减轻胃肠道辐射综合征，增加肠隐窝存活率和肠细胞增殖，并减少细胞凋亡。
T13862L	Recilisib sodium Brand name: Ex-RAD,ON 01210.Na,ON01210,ON-01210
	Recilisib, also known as ON 01210.Na, is a radioprotectant, which modifys cell cycle distribution patterns in cancer cells subjected to radiation therapy, and it has been identified as a potential candidate for radiation protection studies. It appears tha
T33407	MitoEbselen-2 chloride MitoPeroxidase-2,MitoPeroxidase 2,MitoEbselen 2,MitoEbselen-2
	MitoEbselen-2 is a radiation mitigator which reduces lipid hydroperoxides and prevents apoptotic cell death. When administered 24 hours postirradiation, MitoEbselen-2 was shown to increase the survival of mice exposed to whole body γ-irradiation.
T35821	CAY10721
	CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.
T33487	Motexafin gadolinium PCI0120,Gd texaphyrin,PCI-0120,PCI 0120,Gd-Texgadolinium,API-GP 3
	Motexafin gadolinium, also known as PCI 0120, is a synthetic metallotexaphyrin with radiosensitizing and chemosensitizing properties. Motexafin gadolinium accumulates in tumor cells preferentially due to their increased rates of metabolism, generating rea
T71908	NU1085
	NU1085 is a potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of NU1085 [Ki = 6 nM], in combination with temozolomide (TM) or topotecan (TP) have been studied in 12 human tumor cell lines (lung, colon, ovary, and breast cancer). Cells were treated with increasing concentrations of TM or TP +/- NU1085 (10 microM) for 72 h.
T11449	Golotimod hydrochloride (229305-39-9 free base) Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride	STAT	JAK/STAT signaling; Stem Cells
	Golotimod (SCV 07) hydrochloride 是一种免疫调节肽，具抗菌活性，能显著提升抗结核疾病研究效果。该化合物通过刺激胸腺和脾细胞增殖、改善巨噬细胞功能，展现其生物调节能力。此外，Golotimod hydrochloride 通过抑制STAT3信号传导，有效调节接受放疗或与顺铂联用治疗动物模型中的口腔粘膜炎持续时间和严重程度。还显示出对研究复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 具有潜在应用价值。
T68708	Denibulin HCl
	Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy.
T62527	INO-1001
	INO-1001 是一种有效的、选择性聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂，具有抗肿瘤活性。INO-1001 是一种有效的辐射敏感性增强剂，能够利用干扰 DNA 修复机制，进而提高辐射诱导的细胞杀伤，使坏死细胞死亡。
T68870	SU-11752
	SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited.
T71966	PD-128763
	PD-128763 is a selective inhibitor of poly(ADP-ribose) polymerase. PD-128763 has an IC50 value against the purified enzyme approximately 50X lower than 3-aminobenzamide (3-AB), a widely used specific inhibitor of the enzyme. Exposure of exponentially growing cells to a noncytotoxic concentration (0.5 mM) of PD 128763 for 2 h immediately following X irradiation increased their radiation sensitivity, modifying both the shoulder and the slope of the survival curve. When recovery from sublethal dama...
T78107	Reltecimod TFA AB-103 TFA
	Reltecimod (AB-103) TFA 是一款针对 T 细胞特异性表面糖蛋白CD28(TP44) 的拮抗剂。该化合物能够有效抵御各类细菌感染、细菌产生的外毒素和内毒素，以及电离辐射。其通过特异性目标定位并调节 CD28/B7-2 共刺激通路以减弱炎症反应，但并不完全抑制该通路。Reltecimod TFA 主要用于坏死性软组织感染(NSTIs)的研究。
T83704	A20FMDV2 TFA
	A20FMDV2是一种由口蹄疫病毒（FMDV）血清型O的VP1衣壳蛋白上的α-螺旋RGD细胞相互作用域组成的肽，能够结合到αVβ6整合素上。该化合物在表达人αVβ6的H357舌鳞状细胞癌细胞中抑制αVβ6整合素依赖的细胞粘附（IC50 = 1.2 µM）。与111indium-DTPA耦合时，A20FMDV2（20 MBq）可结合于在乳腺癌小鼠异种移植模型中内源性表达的αVβ6整合素，用于放射成像分析。
T36991	Monascuspiloin
	Monascuspiloin is a fungal metabolite that has been found inM. pilosusM93-fermented rice.1It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 μM) decreases viability of PC3 cells and has an additive effect on the reduction in viability of PC3 cells induced by irradiation when used at a concentration of 25 μM. It induces intratumor apoptosis and autophagy and reduces tumor growth in a PC3 mouse xenograft model when administered at doses of 40 ...
T35701	FSL-1 TFA
	FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1]. FSL-1 TFA induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells[2]. FSL-1 significantly reduces HSV-2 replication in human vaginal epithelial cells (EC)[1].FSL-1 induces significant resistance to experimental genital HSV-2 infection through elaboration of a specific cytokine response profile[1].FSL-1 (50 ng/mL, 24 hours) induce...

化合物

Cat.No: T2046

Synonym: Nimorazol,Nitrimidazine,尼莫唑,K-1900,Naxogin,尼莫拉唑

Target: Others, Antibiotic, Parasite

Cat.No: T2020

Target: Others

Cat.No: T6970

Synonym: RK-33,RK 33

Target: COX

Cat.No: T2386

Synonym: S-7701,AMR-69,S-7701,AMR69,吡非尼酮

Target: CCR, TGF-beta/Smad

Cat.No: T22070

Target: LPA Receptor

Recilisib sodium

Cat.No: T13862L

Synonym: Brand name: Ex-RAD,ON 01210.Na,ON01210,ON-01210

MitoEbselen-2 chloride

Cat.No: T33407

Synonym: MitoPeroxidase-2,MitoPeroxidase 2,MitoEbselen 2,MitoEbselen-2

Cat.No: T35821

Motexafin gadolinium

Cat.No: T33487

Synonym: PCI0120,Gd texaphyrin,PCI-0120,PCI 0120,Gd-Texgadolinium,API-GP 3

Cat.No: T71908

Golotimod hydrochloride (229305-39-9 free base)

Cat.No: T11449

Synonym: Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride

Target: STAT

Cat.No: T68708

Cat.No: T62527

Cat.No: T68870

Cat.No: T71966

Cat.No: T78107

Synonym: AB-103 TFA

Cat.No: T83704

Cat.No: T36991

Cat.No: T35701

Cat. No.	Product Name	Target	Signaling Pathways
T2A2532	L-Histidine Glyoxaline-5-alanine,L-(-)-Histidine,L-组氨酸,histidine,组氨酸,L-Hisidine	Mitochondrial Metabolism; Endogenous Metabolite	Metabolism
	L-Histidine (L-(-)-Histidine) 是人类生长和组织修复所需的一种半必需氨基酸(儿童应从食物中获得)。 L-Histidine 是线粒体谷氨酰胺转运的抑制剂。

天然产物

Cat.No: T2A2532

Synonym: Glyoxaline-5-alanine,L-(-)-Histidine,L-组氨酸,histidine,组氨酸,L-Hisidine

Target: Mitochondrial Metabolism, Endogenous Metabolite

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