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Search Results for " cell-penetration "

14

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2354	UNC 0631 UNC0631	Histone Methyltransferase	Chromatin/Epigenetic
	UNC 0631 是一种有效的组蛋白甲基转移酶 G9a 抑制剂，IC50值为 4 nM。它有效降低 MDA-MB-231 细胞中 H3K9me2的水平，IC50为 25 nM。
TQ0232	UNC0646 UNC 0646	Histone Methyltransferase	Chromatin/Epigenetic
	UNC0646 是一种有效的、选择性的同源蛋白赖氨酸甲基转移酶 G9a 和 GLP 抑制剂，IC50分别为 6 和 15 nM，对 G9a/GLP 的选择性比 SETD7、SUV39H2、SETD8 和 PRMT3 高。它降低 MDA-MB-231 细胞中H3K9me2的水平，IC50为 26 nM。
TP2505L	LAH4 acetate KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)	Antibacterial	Microbiology/Virology
	LAH4 acetate 是所设计的两性肽抗生素的α -螺旋结构，能够与DNA 络合，与细胞表面膜结合后被包裹在核内体中，随着pH 值的下降破坏核内体膜。具有强大的抗菌、核酸转染和细胞渗透活性。LAH4 acetate 具有较高的质粒DNA 传递能力。LAH4 acetate 对细菌膜外膜中的阴离子脂具有很强的亲和力。
T11797	L-690488	Others	Others
	L-690488 has more effective cell penetration than L-690330. L-690488 is a prodrug of L-690330 and is a selective inositol monophosphatase (IMPase) inhibitor.
T61701	SHP2-IN-9
	SHP2-IN-9 is a potent inhibitor (IC50 = 1.174 μM) specifically targeting the SHP2 protein, displaying improved penetration across the blood-brain barrier. It exhibits a remarkable 85-fold selectivity for SHP2 over SHP1. By inhibiting SHP2-mediated cell signal transduction and impairing cancer cell proliferation, SHP2-IN-9 effectively suppresses the growth of both cervix cancer tumors and glioblastoma in vivo [1].
T17454	ATP-polyamine-biotin	Others	Others
	ATP-polyamine-biotin is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ± 1 mM. ATP-polyamine-biotin is shown to promote biotin labeling
T60970	Caprochlorone
	Caprochlorone 对正痘病毒具有抗病毒活性，可以降低被感染的小鼠肺部中流感病毒的滴度。Caprochlorone 可以抑制病毒穿透细胞，并且延迟新形成的病毒从细胞释放。
T68547	SNJ-1945
	SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) and rotenone. SNJ-1945 reduces murine retinal cell death in vitro and in vivo. SNJ-1945 has good aqueous solubility, can prevents the heart from KCl arrest-reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteolysis of alpha-fodrin a...
T81526	Pegsebrenatide NLY01
	Pegsebrenatide (NLY01) 是一种具有扩展半衰期和优良血脑屏障穿透能力的长效GLP-1R激动剂。该化合物能够抑制A1型星形胶质细胞的活化，降低多巴胺能神经元凋亡，并在帕金森病（PD）小鼠模型中改善运动功能障碍。
T82010	JDB175	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	JDB175是一种具有口服活性的高选择性BTK抑制剂，能够有效穿透血脑屏障。在中枢神经系统淋巴瘤的小鼠模型中，JDB175显示出良好的抗肿瘤活性，并未观察到显著毒性。它能有效地抑制人淋巴瘤细胞的BTK信号通路，阻止细胞周期，促进细胞凋亡。
T71577	KOS-1584
	KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration,...
T75762	LAH4 TFA
	LAH4 TFA是一种两亲性肽抗生素，以α螺旋形式表现出显著的抗菌(antimicrobial)、核酸转染(nucleic acid transfection)及细胞穿透能力。它在传递质粒DNA方面显示出较高效能，并对细菌外膜中的阴离子脂质展现强烈亲和力。
T68860	Iso-Fludelone
	Iso-Fludelone is the third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as we...
T61388	hAChE/Aβ1-42-IN-1
	hAChE/Aβ1-42-IN-1 (Compound 16) 是一种有效的 hAChE 和 Aβ1-42聚集抑制剂。hAChE/Aβ1-42-IN-1 对 hepG2 细胞系显示出可接受的相对安全性，并具有良好的 BBB 渗透性和较宽的安全范围。hAChE/Aβ1-42-IN-1具有研究阿尔茨海默病 (AD) 的潜力。

化合物

Cat.No: T2354

Synonym: UNC0631

Target: Histone Methyltransferase

Cat.No: TQ0232

Synonym: UNC 0646

Target: Histone Methyltransferase

Cat.No: TP2505L

Synonym: KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)

Target: Antibacterial

Cat.No: T11797

Target: Others

Cat.No: T61701

ATP-polyamine-biotin

Cat.No: T17454

Target: Others

Cat.No: T60970

Cat.No: T68547

Cat.No: T81526

Synonym: NLY01

Cat.No: T82010

Target: BTK

Cat.No: T71577

Cat.No: T75762

Cat.No: T68860

hAChE/Aβ1-42-IN-1

Cat.No: T61388

Cat. No.	Product Name	Target	Signaling Pathways
T4820	Maleimide 马来酰亚胺,2,5-Pyrroledione	Others	Others
	Maleimide (2,5-Pyrroledione) 可用于制备荧光探针，主要用于硫醇分析物的特异性检测。它也可用于制备用于癌症研究的抗体-药物偶联物 (ADC)。
T3229	Cytochalasin D	ATPase; p38 MAPK; Calcium Channel; Akt; PI3K	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit

天然产物

Cat.No: T4820

Synonym: 马来酰亚胺,2,5-Pyrroledione

Target: Others

Cat.No: T3229

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

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