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Search Results for " cardiotonic "

21

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1265	Amrinone Inamrinone,Inocor,氨力农,Wincoram	TNF; PDE	Apoptosis; Metabolism
	Amrinone (Inocor) 是一种正性肌力血管扩张剂，是一种具有口服活性的，非糖苷和非儿茶酚胺的强心剂，也是一种选择性磷酸二酯酶 III (phosphodiesterase III) 抑制剂，能够防止环磷酸腺苷分解，从而增加环磷酸腺苷水平。
T24579	Oxyfedrine L-form HCl Modacor,Oxyfedrine L-form hydrochloride,D563,Ildamen,D 563,D-563	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Oxyfedrine L-form HCl (Ildamen) 是β肾上腺素受体的部分激动剂，用作冠状动脉血管扩张剂和强心剂。
T34987	UK 1745 UK1745,UK-1745
	UK 1745 is a novel drug of cardiotonic.
T31560	Dobutamine lactobionate
	Dobutamine lactobionate is a cardiotonic.
T30134	AR-L 57 CL
	AR-L 57 CL is a cardiotonic agent.
T8149L	Dobutamine tartrate
	Dobutamine tartrate is a cardiotonic.
T32694	Levdobutamine lactobionate LY206243 lactobionate,LY 206243 lactobionate,LY-206243 lactobionate
	Levdobutamine lactobionate is a cardiotonic.
T30314	Bemarinone ORF16600,ORF-16600
	Bemarinone is a clinical cardiotonic agent.
T68997	L-Phenylephrine
	L-Phenylephrine is an alpha-adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
T32218	Isomazole hydrochloride
	Isomazole hydrochloride is a cardiotonic.
T23623	Acrihellin Acrihellinum
	Acrihellin is a cardioactive steroid, a cardiotonic drug.
T80461	Anthopleurin-C	Sodium Channel	Membrane transporter/Ion channel
	Anthopleurin-C (APE 2-1)为一种正性肌力作用显著的强心多肽。
T69318	Tazolol HCl
	Tazolol HCl is a selective beta1-agonist, coronartherapeutic agent, and cardiotonic agent.
T68742	Inamrinone lactate
	Inamrinone lactate is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
T13599	Benzofurodil CB4091,Benfurodil,Eudilat	Others	Others
	Benzofurodil is cardiotonic used for the chronic treatment of congestive heart failure.
T68251	Domipizone
	Domipizone is a platelet aggregation inhibitor, cardiotonic and vasodilator.
T34409	RS 1893 RS-1893,RS1893
	RS 1893 is an orally active cardiotonic agent and its structure is different from that of cardiac glycosides and beta-stimulants.
T71473	AWD 122-60
	AWD 122-60 is a cardiotonic bipyridine that inhibits adenosine triphosphate-sensitive potassium channels of mouse skeletal muscle.
T13882	SCH00013	Others	Others
	SCH00013 is an agent of cardiotonic that primarily acts via an increase in myofibrillar Ca++ sensitivity. SCH00013 have a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4.
T70975	Carsatrin succinate
	Carsatrin succinate is the salt form of Carsatin, a purinylpiperazine derivative used as a cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbi...
T71122	Carsatrin (free base)
	Carsatrin is purinylpiperazine derivative. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbine, or prazosin

化合物

Cat.No: T1265

Synonym: Inamrinone,Inocor,氨力农,Wincoram

Target: TNF, PDE

Oxyfedrine L-form HCl

Cat.No: T24579

Synonym: Modacor,Oxyfedrine L-form hydrochloride,D563,Ildamen,D 563,D-563

Target: Adrenergic Receptor

Cat.No: T34987

Synonym: UK1745,UK-1745

Dobutamine lactobionate

Cat.No: T31560

Cat.No: T30134

Dobutamine tartrate

Cat.No: T8149L

Levdobutamine lactobionate

Cat.No: T32694

Synonym: LY206243 lactobionate,LY 206243 lactobionate,LY-206243 lactobionate

Cat.No: T30314

Synonym: ORF16600,ORF-16600

L-Phenylephrine

Cat.No: T68997

Isomazole hydrochloride

Cat.No: T32218

Cat.No: T23623

Synonym: Acrihellinum

Cat.No: T80461

Target: Sodium Channel

Cat.No: T69318

Inamrinone lactate

Cat.No: T68742

Cat.No: T13599

Synonym: CB4091,Benfurodil,Eudilat

Target: Others

Cat.No: T68251

Cat.No: T34409

Synonym: RS-1893,RS1893

Cat.No: T71473

Cat.No: T13882

Target: Others

Carsatrin succinate

Cat.No: T70975

Carsatrin (free base)

Cat.No: T71122

Cat. No.	Product Name	Target	Signaling Pathways
TN7129	Methyl maslinate 马斯里酸甲酯,Maslinic acid methyl ester,Crategolic acid methyl ester	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Methyl maslinate (Maslinic acid methyl ester) 是一种具有强心和抗心律失常特性的 β-肾上腺素受体拮抗剂。Methyl maslinate 可用于高血压研究。
T5581	6-(γ,γ-Dimethylallylamino)purine N6-(2-lsopentenyl)adenine,三刺皂荚碱,Triacanthine	Others	Others
	6-(γ,γ-Dimethylallylamino)purine (Triacanthine) 是植物生长调节剂。
T7995	α-Angelica lactone α-当归内酯,当归内酯,Alpha-Angelica Lactone	Others; GST	Others; oxidation-reduction
	α-Angelica lactone 是一种乙烯基亲核试剂，也是一种天然存在的抗癌剂。它可以得到手性的 δ-氨基 γ，γ-二取代丁烯醇内酯羰基衍生物，并在 γ-碳上表现出亲电子俘获。它通过选择性增强谷胱甘肽-S-硫转移酶 (GST) 和 UDP-葡糖苷转移酶 (UGT) 解毒酶发挥强大的化学保护作用。
T1719	Bufalin	ATPase	Membrane transporter/Ion channel
	Bufalin 是蟾酥中的一种成分，是Na+/K+-ATPase 抑制剂，具有抗肿瘤活性，可与其基 α1、α2 和 α3 结合，Kd 值分别为 42.5、45 和 40 nM。
T6S1684	8-Gingerol	Antioxidant; Antibacterial; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction
	8-Gingerol 分离自姜的根状茎，是口服有效的 TRPV1激活剂，EC50值为5.0 µM。8-Gingerol 抑制 COX-2，还能抑制体外 H. pylori 的生长。
TN1912	Marinobufogenin 南美蟾毒精,Marinobufagenin	ATPase; EGFR	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure.
TN5213	Uzarigenin	Others	Others
	Uzarigenin has cardiotonic activities.
TN3742	Cycloeucalenol	Others	Others
	Cycloeucalenol produces mild cardiotonic effects. Cycloeucalenol and its regio-isomer were present in a ratio of 1.04:1, a dose-dependent decrease in cell viability was observed.

天然产物

Methyl maslinate

Cat.No: TN7129

Synonym: 马斯里酸甲酯,Maslinic acid methyl ester,Crategolic acid methyl ester

Target: Adrenergic Receptor

6-(γ,γ-Dimethylallylamino)purine

Cat.No: T5581

Synonym: N6-(2-lsopentenyl)adenine,三刺皂荚碱,Triacanthine

Target: Others

α-Angelica lactone

Cat.No: T7995

Synonym: α-当归内酯,当归内酯,Alpha-Angelica Lactone

Target: Others, GST

Cat.No: T1719

Target: ATPase

Cat.No: T6S1684

Target: Antioxidant, Antibacterial, TRP/TRPV Channel

Marinobufogenin

Cat.No: TN1912

Synonym: 南美蟾毒精,Marinobufagenin

Target: ATPase, EGFR

Cat.No: TN5213

Target: Others

Cat.No: TN3742

Target: Others

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