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14

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14968	Cinanserin hydrochloride SQ 10643	Influenza Virus; 5-HT Receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Cinanserin hydrochloride (SQ 10643) 是一种高亲和力拮抗剂，对 5-HT2 受体的Ki 值为 41 nM。它也是严重急性呼吸综合征冠状病毒的 3C 样蛋白酶抑制剂。
T36336	Burnettramic Acid A
	Burnettramic acid A is a fungal metabolite originally isolated fromA. burnettiithat has diverse biological activities.1It is active againstB. subtilis,S. aureus,C. albicans, andS. cerevisiae(IC50s = 2.3, 5.9, 0.5, and 0.2 μg/ml, respectively). Burnettramic acid A is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 13.8 and >100 μg/ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic aci...
T125026	Laburnine
	Laburnine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125026。
T124750	14,15-Didehydroisoeburnamine
	14,15-Didehydroisoeburnamine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124750。
T35056	Vindeburnol RU 24722,RU24722,RU-24722
	Vindeburnol is a cerebral vasodilator vincamine analog that bears neuroprotective properties.
T131582	Eburnamonine
	Eburnamonine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131582。
T21024	Ornithine-α-ketoglutarate L-Ornithine-α-ketoglutarate,Ornithine α ketoglutarate,L Ornithine α ketoglutarate,Ornithine α-ketoglutarate,OKG,鸟氨酸α-酮戊二酸	Others	Others
	Ornithine-α-ketoglutarate (L-Ornithine-α-ketoglutarate) 是由 2 个鸟氨酸分子和 1 个 α-酮戊二酸分子形成的盐。 Ornithine-α-ketoglutarate (L-Ornithine-α-ketoglutarate) 可改善慢性营养不良(例如老年人)和急性营养不良患者(尤其是烧伤和创伤患者)的营养状况。
T1026	Mafenide hydrochloride 4-Aminomethylbenzenesulfonamide hydrochloride,盐酸磺胺米隆	Antibacterial; Antibiotic; Carbonic Anhydrase	Metabolism; Microbiology/Virology
	Mafenide hydrochloride (4-Aminomethylbenzenesulfonamide hydrochloride) 是一种有效的磺酰胺类抗菌剂，可用于烧伤创面。它通过抑制核苷酸合成，对革兰氏阳性和革兰氏阴性生物均具有活性。
T8122	Mafenide Acetate	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Mafenide Acetate 是一种磺酰胺类抗菌剂，可用于烧伤创面。它通过抑制核苷酸合成，对革兰氏阳性和革兰氏阴性生物有活性。
T23302	(S)-(-)-Propranolol hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	(S)-(-)-Propranolol hydrochloride 是一种有效的肾上腺素能受体 (β-adrenergic receptor) 拮抗剂，具有抗高血压活性和潜在的抗癌活性，对β1，β2，和β3受体有抑制作用。(S)-(-)-Propranolol hydrochloride 可改善严重烧伤患者的预后，可用于研究酒精症。
T67965	Torbafylline	cAMP; PI3K; PDE	GPCR/G Protein; Metabolism; PI3K/Akt/mTOR signaling
	Torbafylline 是黄嘌呤衍生物，是磷酸二酯酶（PDE）抑制剂，通过激活 PDE4/cAMP/EPAC/PI3K/Akt 途径减弱烧伤诱导的大鼠骨骼肌蛋白水解，抑制癌症和败血症大鼠增强的骨骼肌泛素 - 蛋白酶体依赖性蛋白水解。
T21258	Mafenide Mafenide acetate,磺胺米隆,Ambamide,Homonal,Benzamsulfonamide,Homosul,Emilene
	Mafenide acetate, a sulfonamide, inhibits the enzyme carbonic anhydrase and is used as a topical anti-infective drug, especially in burn therapy.
T35457	(±)12(13)-DiHOME (±)12(13)-DiHOME,Isoleukotoxin diol
	(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME , a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin. [1] It is formed from 12(13)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils. [2] 12(13)-DiHOME is toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells, unlike isoleukotoxin, which is only toxic to cells containing sEH.[1] [2] Levels of 12(13)-DiHOME are increased in rat spinal cord following burn injury, and it enhances cold tolerance...
T31194	Dalapon Basfapon B,Dowpon M,Dawpon-Rae
	Dalapon is a selective herbicide used to control perennial grasses. The major use of dalapon is on food crops including sugarcane and sugar beets. Its use is no longer authorized in France. The National Institute for Occupational Safety and Health in the

化合物

Cinanserin hydrochloride

Cat.No: T14968

Synonym: SQ 10643

Target: Influenza Virus, 5-HT Receptor

Burnettramic Acid A

Cat.No: T36336

Cat.No: T125026

14,15-Didehydroisoeburnamine

Cat.No: T124750

Cat.No: T35056

Synonym: RU 24722,RU24722,RU-24722

Cat.No: T131582

Ornithine-α-ketoglutarate

Cat.No: T21024

Synonym: L-Ornithine-α-ketoglutarate,Ornithine α ketoglutarate,L Ornithine α ketoglutarate,Ornithine α-ketoglutarate,OKG,鸟氨酸α-酮戊二酸

Target: Others

Mafenide hydrochloride

Cat.No: T1026

Synonym: 4-Aminomethylbenzenesulfonamide hydrochloride,盐酸磺胺米隆

Target: Antibacterial, Antibiotic, Carbonic Anhydrase

Mafenide Acetate

Cat.No: T8122

Target: Others, Antibacterial, Antibiotic

(S)-(-)-Propranolol hydrochloride

Cat.No: T23302

Target: Adrenergic Receptor

Cat.No: T67965

Target: cAMP, PI3K, PDE

Cat.No: T21258

Synonym: Mafenide acetate,磺胺米隆,Ambamide,Homonal,Benzamsulfonamide,Homosul,Emilene

(±)12(13)-DiHOME

Cat.No: T35457

Synonym: (±)12(13)-DiHOME,Isoleukotoxin diol

Cat.No: T31194

Synonym: Basfapon B,Dowpon M,Dawpon-Rae

Cat. No.	Product Name	Target	Signaling Pathways
T2149	Vinburnine Eburnalritardo,L-Eburnamonine,长春布宁,Vincamone,(-)-Eburnamonine,(-)-Vincamone	Others; Drug Metabolite	Metabolism; Others
	Vinburnine (Eburnalritardo) 是一种长春花生物碱，是长春胺的代谢物和是血管扩张剂。
TN5612	Viburnumoside
	Viburnumoside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5612，CAS号为 2222365-74-2。
T36337	Burnettramic Acid A aglycone
	Burnettramic acid A aglycone is a fungal metabolite and an aglycone form of burnettramic acid A originally isolated fromA. burnettiithat has anticancer activity.1It is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 8.4 and >100 μg/ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic acids: Rare PKS-NRPS-derived bolaamphiphilic pyrrolizidinediones from an Australian fungus, Aspergillus...
T73207	Laburnetin
	Laburnetin 是一种异黄酮类抗菌剂 (antibacterial agent)。Laburnetin 对真菌、S. vesicarium 具有抗菌活性。Laburnetin 增强了耐甲氧西林 (Methicillin) 金黄色葡萄球菌 (MRSA) 菌株对甲氧西林的敏感性。Laburnetin 可用于控制栽培物种的虫害。
T6S1885	Benzoylmesaconine Mesaconine 14-benzoate,苯甲酰新乌头原碱	Others	Others
	Benzoylmesaconine (Mesaconine 14-benzoate) 是乌头汤最丰富的组分。其中乌头汤可用于研究类风湿性关节炎。

天然产物

Cat.No: T2149

Synonym: Eburnalritardo,L-Eburnamonine,长春布宁,Vincamone,(-)-Eburnamonine,(-)-Vincamone

Target: Others, Drug Metabolite

Cat.No: TN5612

Burnettramic Acid A aglycone

Cat.No: T36337

Cat.No: T73207

Benzoylmesaconine

Cat.No: T6S1885

Synonym: Mesaconine 14-benzoate,苯甲酰新乌头原碱

Target: Others

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