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22

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38845	Dodecamethylpentasiloxane	Parasite	Microbiology/Virology
	Dodecamethylpentasiloxane 可用作臭虫杀虫剂。 Dodecamethylpentasiloxane 是硅氧烷的一种成分，可用作硅油。
T32046	HBED CHELII,CHEL II,CHEL-II	Others	Others
	HBED (CHELII) 是一种铁螯合剂，可用于治疗慢性铁过载和急性铁中毒的研究。
T26760	Bedoradrine sulfate KUR1246,MN 221 sulfate,KUR1246 sulfate,MN221 sulfate,KUR 1246 sulfate,MN-221 sulfate,KUR 1246,KUR-1246 sulfate,MN-221,MN 221,MN221,KUR-1246	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bedoradrine sulfate（MN-221 sulfate）是一种超选择性β2激动剂，可用于治疗哮喘加重和慢性阻塞性肺病。
T82236	HBED-CC-tris(tert-butyl ester)	Others	Others
	HBED-CC-tris(tert-butyl ester)是HBED-CC的一种单价变体，可用于合成基于非对称 HBED-CC 的放射性化合物，可用于肿瘤成像。
T3278	Piribedil EU-4200,Trivastan,ET-495,Trivastal	Dopamine Receptor; Histone Methyltransferase; Adrenergic Receptor	Chromatin/Epigenetic; GPCR/G Protein; Neuroscience
	Piribedil (Trivastan) 是多巴胺 D2受体激动剂，对 hα1A-肾上腺素受体也显示出拮抗作用。
T70047	Bedoradrine Bedoradrine free base	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bedoradrine free base 是一种新型高选择性 β2-肾上腺素受体激动剂，可用于治疗哮喘和慢性阻塞性肺疾病。
T21023	Bedaquiline fumarate TMC 207,R403323,TMC-207,TMC207,R-403323,贝达喹啉富马酸盐,R 403323	Antibacterial; Antibiotic	Microbiology/Virology
	Bedaquiline fumarate (TMC207) 是二芳基喹啉抗生素，作用于 ATP 合成酶，常用于结核杆菌感染的研究。
T37076	Zabedosertib BAY 1834845	IRAK	Immunology/Inflammation; NF-κB
	Zabedosertib (BAY 1834845) 是一种 IRAK4 抑制剂，具有免疫调节潜能。最新研究表明，Zabedosertib 可预防急性呼吸窘迫综合征
T2585	Bedaquiline R207910,TMC207,贝达喹啉	Antibacterial; Antibiotic	Microbiology/Virology
	Bedaquiline (R207910) 是一种二芳基喹啉药物，能同时靶向 c-亚基和 ε-亚基，抑制结核分枝杆菌 (Mtb) F1FO-ATP 合酶。它具有解偶联活性和有用于耐多药结核病的潜力。
T30311	Bederocin REP 8839,REP-8839,REP8839	Antibacterial	Microbiology/Virology
	Bederocin (REP8839) 是一种新型的甲硫酰基tRNA 合成酶(METS)抑制剂，对临床分离的金黄色葡萄球菌、化脓性链球菌和其他临床重要的革兰氏阳性细菌具有有效的抗菌活性。
T3278L	Piribedil Maleate
	Piribedil Maleate is a direct agonist of dopamine that acts by showing selectivity for the D3 subtype.
T24433	MBED
	MBED is a RyR agonist.
T23161	Piribedil dihydrochloride	Others	Others
	dopamine agonist
T12486	Piribedil D8 ET-495 D8	Others	Others
	Piribedil D8 is the deuterium labeled Piribedil, which is an agent of antiparkinsonian.
T74204	Trabedersen
	Trabedersen (AP 12009) 是一种反义寡脱氧核苷酸，可特异性抑制 TGF-β2(TGF-beta/Smad)。Trabedersen 可用于研究恶性脑肿瘤和其他过度表达 TGF-β2的实体瘤，例如皮肤、胰腺和结肠肿瘤。
T24995	Abediterol napadisylate LAS100977 napadisylate
	Abediterol napadisylate is a novel long-acting β2-agonist in persistent asthma that is efficacy, safe, and tolerable.
T76813	Bedinvetmab
	Bedinvetmab (ZTS-00508841)为针对神经生长因子(NGF)的犬单克隆抗体(mAb)，通过抑制NGF与肌球蛋白原受体激酶A(trkA)及p75神经营养蛋白受体(p75NTR)的相互作用，应用于犬骨关节炎疼痛的研究。
T29518	Abediterol LAS100977,LAS 100977,LAS-100977
	Abediterol (LAS100977) is a new potent, long-acting inhaled beta (2) -adrenergic receptor agonist being developed for the treatment of asthma and chronic obstructive pulmonary disease.
T61027	Piribedil hydrochloride
	Piribedil hydrochloride 可用于帕金森病，循环系统疾病，癌症等的研究。Piribedil hydrochloride 以0.18 μM 的EC50值抑制 MLL1 甲基转移酶的活性。Piribedil hydrochloride 是口服有效的多巴胺 D2 和多巴胺 D3 激动剂，也是 α2-肾上腺素能受体的拮抗剂。
TP1257L	Adrenomedullin (AM) (22-52), human acetate Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base）	CGRP Receptor	GPCR/G Protein; Neuroscience
	Adrenomedullin (AM) (22-52), human acetate 是猫后肢血管床中 CGRP 受体和肾上腺髓质素受体的拮抗剂。
T76011	Adrenomedullin (16-31), human TFA
	Adrenomedullin(16-31), human TFA 为人类肾上腺髓质素(hADM)之16至31氨基酸片段，对CGRP1受体显示高亲和力。该化合物在大鼠体内可提高全身血压，但对猫无效。
T37435	PACAP-related Peptide (rat) (trifluoroacetate salt)	PACAP	GPCR/G Protein
	PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in rat hypothalamus as well as within the nerves of the median eminence, the anterior pituitary, bed nucleus of the stria terminalis, cerebellum, cerebral cortex, and amygdala. PRP is also expressed in vaginal, uterine cervica...

化合物

Dodecamethylpentasiloxane

Cat.No: T38845

Target: Parasite

Cat.No: T32046

Synonym: CHELII,CHEL II,CHEL-II

Target: Others

Bedoradrine sulfate

Cat.No: T26760

Synonym: KUR1246,MN 221 sulfate,KUR1246 sulfate,MN221 sulfate,KUR 1246 sulfate,MN-221 sulfate,KUR 1246,KUR-1246 sulfate,MN-221,MN 221,MN221,KUR-1246

Target: Adrenergic Receptor

HBED-CC-tris(tert-butyl ester)

Cat.No: T82236

Target: Others

Cat.No: T3278

Synonym: EU-4200,Trivastan,ET-495,Trivastal

Target: Dopamine Receptor, Histone Methyltransferase, Adrenergic Receptor

Cat.No: T70047

Synonym: Bedoradrine free base

Target: Adrenergic Receptor

Bedaquiline fumarate

Cat.No: T21023

Synonym: TMC 207,R403323,TMC-207,TMC207,R-403323,贝达喹啉富马酸盐,R 403323

Target: Antibacterial, Antibiotic

Cat.No: T37076

Synonym: BAY 1834845

Target: IRAK

Cat.No: T2585

Synonym: R207910,TMC207,贝达喹啉

Target: Antibacterial, Antibiotic

Cat.No: T30311

Synonym: REP 8839,REP-8839,REP8839

Target: Antibacterial

Piribedil Maleate

Cat.No: T3278L

Cat.No: T24433

Piribedil dihydrochloride

Cat.No: T23161

Target: Others

Cat.No: T12486

Synonym: ET-495 D8

Target: Others

Cat.No: T74204

Abediterol napadisylate

Cat.No: T24995

Synonym: LAS100977 napadisylate

Cat.No: T76813

Cat.No: T29518

Synonym: LAS100977,LAS 100977,LAS-100977

Piribedil hydrochloride

Cat.No: T61027

Adrenomedullin (AM) (22-52), human acetate

Cat.No: TP1257L

Synonym: Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base）

Target: CGRP Receptor

Adrenomedullin (16-31), human TFA

Cat.No: T76011

PACAP-related Peptide (rat) (trifluoroacetate salt)

Cat.No: T37435

Target: PACAP

Cat. No.	Product Name	Target	Signaling Pathways
TN3066	4-Oxobedfordiaic acid	Others	Others
	4-Oxobedfordiaic acid 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3066，CAS号为 68799-38-2。
T19110	(2E,4E,6Z)-Methyl deca-2,4,6-trienoate Methyl (2E,4E,6Z)-decatrienoate	Others	Others
	(2E,4E,6Z)-Methyl deca-2,4,6-trienoate (Methyl (2E,4E,6Z)-decatrienoate) 是一种来自臭虫Thyanta pallidovirens 的小分子化合物，是一种性引诱信息素，具有热不稳定性。
T21296	Desmopressin acetate trihydrate Desmogalen,Adiuretin,Deamino Arginine Vasopressin,Vasopressin 1-Desamino-8-arginine
	Desmopressin acetate is a synthetic replacement for vasopressin, which reduces urine production. Medical use of Desmopressin acetate includes: (a) bed wetting; (b) diabetes insipidus; (c) nighttime urination; (d) clotting disorders.

天然产物

4-Oxobedfordiaic acid

Cat.No: TN3066

Target: Others

(2E,4E,6Z)-Methyl deca-2,4,6-trienoate

Cat.No: T19110

Synonym: Methyl (2E,4E,6Z)-decatrienoate

Target: Others

Desmopressin acetate trihydrate

Cat.No: T21296

Synonym: Desmogalen,Adiuretin,Deamino Arginine Vasopressin,Vasopressin 1-Desamino-8-arginine

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