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26

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T69526	PF-07258669	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	PF-07258669 是一种选择性黑皮质素 4 受体 (MC4) 拮抗剂，可用于研究恶病质和食欲衰退。
T19991	N-desmethylmirtazapine 米氮平杂质D,N-Demethylmirtazapine,Normirtazapine,ORG3838,ORG 3838,J1.061.658A,ORG-3838	Others	Others
	N-desmethylmirtazapine (J1.061.658A) 是mirtazapine 的代谢物。它也常用作抗焦虑药、催眠药、止吐药和食欲兴奋剂。
TP1059	Peptide YY (PYY) (3-36), human Peptide YY (3-36)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Peptide YY (PYY) (3-36), human (Peptide YY (3-36)) 是一种肠胃激素肽，可以激动Y2受体，具有降低食欲的功效。
T1442	Pizotifen Pizotyline,BC-105,苯噻啶	5-HT Receptor	GPCR/G Protein; Neuroscience
	Pizotifen (Pizotyline) 是5-HT2受体的有效拮抗剂，并对5-HT1C 有高亲和力。它是一种强血清素和色胺拮抗剂，具有较弱的抗胆碱能、抗组胺和抗激肽作用，还具有镇静和刺激食欲的特性。
T1519L	Rimonabant SR141716,利莫那班	Cannabinoid Receptor; Antibacterial; Acyltransferase	GPCR/G Protein; Metabolism; Microbiology/Virology
	Rimonabant (SR141716) 是一种选择性的、能透过血脑屏障的中心大麻素受体 1 拮抗剂， Ki 值为 1.8 nM。它也能够抑制分枝杆菌膜蛋白 3。
T24164	Indanorex JL-11698,Dietor,JL11698,Indanorexum,JL 11698
	Indanorex is a stimulant drug. It has appetite suppressant effects and also has antihyperglycemic effects.
T23996	Difemetorex Diphemetoxidine,BA 18189,JB 8035,Difemetorexum,BRN 1651678
	Difemetorex is a stimulant drug of the piperidine class which was used as an appetite suppressant.
T34392	Rosonabant E 6776,E-6776,E6776
	Rosonabant (E-6776）is a CB1 receptor antagonist/reverse agonist that is studying as an appetite suppressant for the treatment of obesity.
T75773	Peptide YY (PYY) (3-36), porcine TFA
	Peptide YY (PYY) (3-36), porcine TFA，为一种肠胃激素肽，作用于Y2受体，具有降低食欲的功能。
T81626	Obestatin(11-23)mouse, rat
	Obestatin(11-23)mouse, rat 是多肽，涉及能量平衡调节，抑制摄食。该化合物能使啮齿类动物食量减少、体重降低、及空肠收缩。
TP1058	Peptide YY (PYY) (3-36), human TFA Peptide YY (3-36) (TFA)
	Peptide YY (PYY) (3-36), human (TFA) is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite[1].
T75899	CART(55-102)(human) TFA
	CART(55-102)(human) TFA，一种与瘦素和神经肽 Y 密切相关的人源饱腹感因子，具有显著的抑制食欲作用。
TP2215	Agouti-related Protein (AGRP) (25-82), human	Others	Others
	Agouti-related peptide (AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is only synthesized in NPY containing cell bodies located in the ventromedial part of the arcuate nucleus in the hypothalamus. The appetite-stimulating effect
T35599	Neuropeptide Y (3-36) (human, rat) (trifluoroacetate salt)
	Neuropeptide Y (NPY) (3-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion. NPY (3-36) is an endogenous peptide produced by cleavage of NPY by dipeptidyl peptidase 4 (DPP-4). It binds selectively to the NPY receptor Y2 (Ki = 0.41 nM in CHP 234 cells) over the Y1 receptor, where it does not bind at concentrations up to 1 μM. NPY (3-36) (0.1 nM) increases migration of human umbilical vein endothelial...
T76328	Oxyntomodulin (swine)
	Oxyntomodulin (swine) 是一种肽类激素，在餐后状态下从肠道释放，作为GLP-1R(GLP-1 受体) 和GCGR(胰高血糖素受体) 的双重激动剂，能够抑制食欲并减少食物摄入。
TP2026	GRP (porcine)
	Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice
T75900	CART(55-102)(rat) TFA
	CART(55-102)(rat) TFA，一种鼠源性饱腹感因子，具强烈抑制食欲作用，与瘦素及神经肽 Y 有密切关联，能诱导焦虑及压力相关行为。
T76093	Peptide YY (pig)
	Peptide YY (pig) 是一种由36个氨基酸组成的胃肠肽，源自猪的十二指肠。该化合物通过激活Y2 receptor来降低食欲和食物摄入量，主要在胰腺的内分泌细胞中发现，对肠动力和心血管系统具有重要影响。
T76366	CART (55-76), rat
	CART (55-76), rat 为一种神经肽，构成CART (55-102)的N端片段，属于鼠源性饱腹感因子，具有显著的抑食作用，并与瘦素及神经肽Y关系紧密。此外，CART (55-76), rat 还能诱发与焦虑和压力相关的行为。
T76365	CART (1-39), Human, Rat
	CART (1-39), Human, Rat, 是一种由其1至39个残基构成的神经肽, 具有明显的减少食欲作用, 被认为是鼠类的饱腹因子, 并与瘦素及神经肽Y有着紧密的联系。它能有效抑制正常及饥饿状态下的摄食行为, 同时也能引发焦虑与压力相关的反应。
T73658	Orexin A (human, rat, mouse) (acetate)
	Orexin A (Hypocretin-1) (human, rat, mouse) acetate 是一种具有镇痛特性的下丘脑神经肽 (可透过血脑屏障)。Orexin A (human, rat, mouse) acetate 也是一种OX1R 激动剂，能以时间和剂量依赖性的方式诱导 SH-SY5Y 细胞BDNF 和TH 蛋白的表达。Orexin A (human, rat, mouse) acetate 可用于食欲调节、神经退行性疾病，以及调节伤害性信息传递的研究。
T35632	Pinolenic Acid
	Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.[1] Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the sa...
T31194	Dalapon Basfapon B,Dowpon M,Dawpon-Rae
	Dalapon is a selective herbicide used to control perennial grasses. The major use of dalapon is on food crops including sugarcane and sugar beets. Its use is no longer authorized in France. The National Institute for Occupational Safety and Health in the
T35633	Pinolenic Acid ethyl ester
	Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro. Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an ...
T83677	Neuropeptide Y (porcine, bovine) TFA NPY (porcine, bovine)
	神经肽Y（Neuropeptide Y, NPY）是一种参与调节食欲、血管收缩、心脏收缩力和肠道分泌的神经肽，同时也是NPY受体Y1、Y2和Y5的激动剂。它在全身范围内表达。NPY能够在表达大鼠Y1或Y2以及表达大鼠Y5的HEK293细胞中选择性抑制由forskolin诱导的cAMP积累，而对表达大鼠Y4受体的L-M(TK-)细胞的影响较小（EC50分别为0.15、2.7、0.66和>1,000 nM)。在分离的豚鼠心脏模型中，NPY能够增加灌注压（EC30 = 1.3 nM）。神经内注射NPY（300 pmol/动物）能够在大鼠中增加食物摄取量。
T35460	β-Endorphin (rat)
	β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities. It is produced via piomelanocortin cleavage in the pituitary gland, hypothalamus, and in lymphocytes, then migrates to its sites of action which include plasma, gut, skin, placenta, cerebrospinal fluid, and cardiac tissues. β-EP induces concentration-dependent decreases in electrically stimulated contraction of the mouse vas deferens that can be reversed by the μ-opioid antagonist CTP and δ-opioid antagon...

化合物

Cat.No: T69526

Target: Melanocortin Receptor

N-desmethylmirtazapine

Cat.No: T19991

Synonym: 米氮平杂质D,N-Demethylmirtazapine,Normirtazapine,ORG3838,ORG 3838,J1.061.658A,ORG-3838

Target: Others

Peptide YY (PYY) (3-36), human

Cat.No: TP1059

Synonym: Peptide YY (3-36)

Target: Neuropeptide Y Receptor

Cat.No: T1442

Synonym: Pizotyline,BC-105,苯噻啶

Target: 5-HT Receptor

Cat.No: T1519L

Synonym: SR141716,利莫那班

Target: Cannabinoid Receptor, Antibacterial, Acyltransferase

Cat.No: T24164

Synonym: JL-11698,Dietor,JL11698,Indanorexum,JL 11698

Cat.No: T23996

Synonym: Diphemetoxidine,BA 18189,JB 8035,Difemetorexum,BRN 1651678

Cat.No: T34392

Synonym: E 6776,E-6776,E6776

Peptide YY (PYY) (3-36), porcine TFA

Cat.No: T75773

Obestatin(11-23)mouse, rat

Cat.No: T81626

Peptide YY (PYY) (3-36), human TFA

Cat.No: TP1058

Synonym: Peptide YY (3-36) (TFA)

CART(55-102)(human) TFA

Cat.No: T75899

Agouti-related Protein (AGRP) (25-82), human

Cat.No: TP2215

Target: Others

Neuropeptide Y (3-36) (human, rat) (trifluoroacetate salt)

Cat.No: T35599

Oxyntomodulin (swine)

Cat.No: T76328

Cat.No: TP2026

CART(55-102)(rat) TFA

Cat.No: T75900

Peptide YY (pig)

Cat.No: T76093

CART (55-76), rat

Cat.No: T76366

CART (1-39), Human, Rat

Cat.No: T76365

Orexin A (human, rat, mouse) (acetate)

Cat.No: T73658

Cat.No: T35632

Cat.No: T31194

Synonym: Basfapon B,Dowpon M,Dawpon-Rae

Pinolenic Acid ethyl ester

Cat.No: T35633

Neuropeptide Y (porcine, bovine) TFA

Cat.No: T83677

Synonym: NPY (porcine, bovine)

β-Endorphin (rat)

Cat.No: T35460

Cat. No.	Product Name	Target	Signaling Pathways
T1399	Sucralose Trichlorosucrose,三氯蔗糖,E955	Others; Endogenous Metabolite	Metabolism; Others
	Sucralose (Trichlorosucrose) 是一种无营养的人工甜味剂 (sweetener) 和代糖，它能够激活保守神经的禁食响应，从而刺激啮齿动物产生食欲。
T2O2721	L-Cysteine Thioserine,L-半胱氨酸,cysteine,半胱氨酸,L-(+)-Cysteine	Endogenous Metabolite	Metabolism
	L-Cysteine (L-(+)-Cysteine) 是人体非必需的含硫氨基酸。L-Cysteine 对蛋白质合成、解毒和多种代谢功能很重要。L-Cysteine 存在于指甲、皮肤和头发的主要蛋白质-角蛋白中，对胶原蛋白的生成、皮肤弹性和质地都很重要。L-Cysteine 是抗氧化剂谷胱甘肽的一种成分，在辅酶A、肝素和生物素等基本生化物质的代谢中起着重要作用，也是氨基酸牛磺酸的制造所必需的。
TCS1709	BENZYLACETONE 苄基丙酮,4-Phenylbutan-2-one,Methyl 2-phenylethyl ketone,4-Phenyl-2-butanone	Tyrosinase	Proteases/Proteasome
	Benzylacetone (4-Phenyl-2-butanone) 是一种从沉香木中提取的芳香族化合物。它具有增强食欲和减少运动的作用。它具有较强且可逆的抗蘑菇酪氨酸酶作用，对单酚酶和双酚酶作用的IC50值分别为 2.8 mM 和 0.6 mM。
TN1740	Homoeriodictyol 高胜草酚,高圣草酚	5-HT Receptor; transporter; Sodium Channel; Drug Metabolite	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Homoeriodictyol 是 Eriocitrin 的代谢物，属于黄酮类。Eriocitrin 是强效抗氧化剂。
T8141	L-Cysteine hydrochloride L-Cysteine HCl,L-半胱氨酸盐酸盐,L-半胱氨酸盐酸盐(无水物)	Others; Endogenous Metabolite	Metabolism; Others
	L-Cysteine hydrochloride (L-Cysteine HCl) 是一种条件必需氨基酸，是硫化氢 (H2S)、牛磺酸谷胱甘肽和等生物特性分子的前体。它能抑制胃饥饿素，抑制啮齿动物和人类的食欲。
TN5283	L-Cysteine hydrochloride hydrate L-Cysteine hydrochloride monohydrate,L-半胱氨酸盐酸盐一水物,L-半胱氨酸盐酸盐一水合物	Others; Endogenous Metabolite	Metabolism; Others
	L-Cysteine hydrochloride hydrate (L-Cysteine hydrochloride monohydrate) 是条件必需氨基酸，是硫化氢、谷胱甘肽和牛磺酸等生物活性分子的前体。它可以抑制胃饥饿素，抑制啮齿动物和人类的食欲。
T4776	Glycerol Glycerin,甘油	Endogenous Metabolite	Metabolism
	Glycerol 是甘油三酯（即脂肪和油）和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
T16285	Neosolaniol	Potassium Channel	Membrane transporter/Ion channel
	Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.

天然产物

Cat.No: T1399

Synonym: Trichlorosucrose,三氯蔗糖,E955

Target: Others, Endogenous Metabolite

Cat.No: T2O2721

Synonym: Thioserine,L-半胱氨酸,cysteine,半胱氨酸,L-(+)-Cysteine

Target: Endogenous Metabolite

Cat.No: TCS1709

Synonym: 苄基丙酮,4-Phenylbutan-2-one,Methyl 2-phenylethyl ketone,4-Phenyl-2-butanone

Target: Tyrosinase

Homoeriodictyol

Cat.No: TN1740

Synonym: 高胜草酚,高圣草酚

Target: 5-HT Receptor, transporter, Sodium Channel, Drug Metabolite

L-Cysteine hydrochloride

Cat.No: T8141

Synonym: L-Cysteine HCl,L-半胱氨酸盐酸盐,L-半胱氨酸盐酸盐(无水物)

Target: Others, Endogenous Metabolite

L-Cysteine hydrochloride hydrate

Cat.No: TN5283

Synonym: L-Cysteine hydrochloride monohydrate,L-半胱氨酸盐酸盐一水物,L-半胱氨酸盐酸盐一水合物

Target: Others, Endogenous Metabolite

Cat.No: T4776

Synonym: Glycerin,甘油

Target: Endogenous Metabolite

Cat.No: T16285

Target: Potassium Channel

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