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17

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3315	Benurestat 贝奴司他,EU-2826	Others; Antibacterial	Microbiology/Virology; Others
	Benurestat (EU-2826) 是有口服活性的脲酶抑制剂，可研究受感染的尿素分解。
T0418	Allylthiourea 阿利硫脲,N-Allylthiourea,Thiosinamine,烯丙基硫脲	MAO; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Allylthiourea (Thiosinamine) 是一种代谢抑制剂，专门抑制氨氧化。
T15393	Glycerol phenylbutyrate 苯丁酸甘油酯,HPN-100	Sigma receptor	GPCR/G Protein
	Glycerol phenylbutyrate (HPN-100) 是一种氨清除剂，也是 sigma-2 受体配体，pKi 为8.02。
T19399	L-Ornithine L-aspartate Ornithine Aspartate,L-鸟氨酸 L-天冬氨酸	Others	Others
	L-Ornithine L-aspartate (Ornithine Aspartate) 由鸟氨酸和天冬氨酸组成。它能够减少血氨浓度，并消除与肝硬化相关的肝性脑病的症状。
T0755	Carglumic Acid Carbaglu,N-Carbamylglutamate,N-Carbamyl-L-glutamic acid,氨甲酰谷氨酸,Carbamylglutamic acid,Carbamino-L-glutamic acid,Ureidoglutaric acid	Others	Others
	Carglumic Acid (Ureidoglutaric acid) 是一种 N-乙酰谷氨酸 (NAG) 的功能类似物和氨甲酰磷酸合成酶 1(CPS1)的活化剂，可用于与 N-乙酰谷氨酸合成酶 (NAGS) 缺陷相关的急性和慢性高氨血症的研究。
T76136	Tryptophanase
	Tryptophanase 是一种细菌酶，可催化色氨酸降解为吲哚、丙酮酸和氨。
T40535	L-2-Aminooxy-3-phenylpropanoic acid
	L-2-Aminooxy-3-phenylpropanoic acid acts as a potent inhibitor of the enzyme L-phenylalanine ammonia-lyase.
T69949	CGP-78608
	CGP-78608 is a glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia.
T40841	L-2-Aminooxy-3-phenylpropanoic acid hydrobromide
	L-2-Aminooxy-3-phenylpropanoic acid hydrobromide is a powerful inhibitor of L-phenylalanine ammonia-lyase, an enzyme responsible for catalyzing the conversion of L-phenylalanine to trans-cinnamic acid.
T69306	Lubabegron fumarate
	Lubabegron, also known as LY591281; LY488756 fumarate, is a veterinary drug used to reduce ammonia emissions from animals and their waste. Ammonia emissions are a concern in agricultural production because of detrimental effects on the environment, human health, and animal health. Lubabegron was approved by the U.S. Food and Drug Administration in 2018 for use in feedlot cattle. Lubabegron is a beta-adrenergic receptor agonist that has the effect of increasing the breakdown of fats and increasin...
T76171	L-Amino acid oxidase
	L-Amino acid oxidase（L-氨基酸氧化酶）是一种含黄素腺嘌呤二核苷酸的同源二聚体，能够将L-氨基酸立体特异性地催化氧化脱氨，生成α-酮酸和氨。
T78350	Glutamate dehydrogenase
	Glutamate dehydrogenase为存在于原核生物与真核生物线粒体中的酶类，适用于氨、α-酮戊二酸、L-谷氨酸及脲酶的酶促反应检测。
T37276	2,5-Deoxyfructosazine (hydrochloride)
	2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL...
T80051	Amidase	Endogenous Metabolite	Metabolism
	Amidases属于腈水解酶超家族，专门催化酰胺水解成羧酸和氨。该酶含有一个约130个氨基酸组成的保守序列，即AS序列，在关键代谢过程中扮演重要角色。
T75312	Citric acid triammonium
	Citric acid triammonium (Triammonium citrate) 由柠檬酸 Citric acid 与氨按 1:3 摩尔比反应而成。 Citric acid triammonium 可以作为碳源制备碳量子点 (CDs)。高氮组分的 Citric acid triammonium 可能促进 CDs 中氮基官能团的形成，从而提高 CDs 的发射色可调性。
T81677	N-Formyl-L-histidine Formyl-L-histidine
	N-Formyl-L-histidine 通过与组氨酸-tRNA合成酶结合展示其活性，其Ki值为4.6 μM。此外，N-Formyl-L-histidine作为L-组氨酸解氨酶的竞争性抑制剂，具有4.26 mM的Ki值，能够有效抑制该酶对L-组氨酸的解氨反应，阻止尿苷酸的生成。
T37139	5'-O-DMT-PAC-dA
	5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1]. [1]. Schulhof JC, et, al. The final deprotection step in oligonucleotide synthesis is reduced to a mild and rapid ammonia treatment by using labile base-protecting groups. Nucleic Acids Res. 1987 Jan 26;15(2):397-416.

化合物

Cat.No: T3315

Synonym: 贝奴司他,EU-2826

Target: Others, Antibacterial

Cat.No: T0418

Synonym: 阿利硫脲,N-Allylthiourea,Thiosinamine,烯丙基硫脲

Target: MAO, Reactive Oxygen Species

Glycerol phenylbutyrate

Cat.No: T15393

Synonym: 苯丁酸甘油酯,HPN-100

Target: Sigma receptor

L-Ornithine L-aspartate

Cat.No: T19399

Synonym: Ornithine Aspartate,L-鸟氨酸 L-天冬氨酸

Target: Others

Cat.No: T0755

Synonym: Carbaglu,N-Carbamylglutamate,N-Carbamyl-L-glutamic acid,氨甲酰谷氨酸,Carbamylglutamic acid,Carbamino-L-glutamic acid,Ureidoglutaric acid

Target: Others

Cat.No: T76136

L-2-Aminooxy-3-phenylpropanoic acid

Cat.No: T40535

Cat.No: T69949

L-2-Aminooxy-3-phenylpropanoic acid hydrobromide

Cat.No: T40841

Lubabegron fumarate

Cat.No: T69306

L-Amino acid oxidase

Cat.No: T76171

Glutamate dehydrogenase

Cat.No: T78350

2,5-Deoxyfructosazine (hydrochloride)

Cat.No: T37276

Cat.No: T80051

Target: Endogenous Metabolite

Citric acid triammonium

Cat.No: T75312

N-Formyl-L-histidine

Cat.No: T81677

Synonym: Formyl-L-histidine

5'-O-DMT-PAC-dA

Cat.No: T37139

Cat. No.	Product Name	Target	Signaling Pathways
TN7125	2-Propen-1-one, 1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-	Others	Others
	2-Propen-1-one, 1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)- 可用于对 L-苯丙氨酸解氨酶的抑制作用的研究。
T0737	L-Ornithine (S)-2,5-Diaminopentanoic acid,L-鸟氨酸,鸟氨酸	Decarboxylase; Amino Acids and Derivatives; Arginase; Endogenous Metabolite	Immunology/Inflammation; Metabolism; Others
	L-Ornithine ((S)-2,5-Diaminopentanoic acid) 具有抗疲劳作用，能够促进氨的排泄和提高能量消耗效率。
T2O2701	L-Ornithine hydrochloride L(+)-Ornithine hydrochloride,(S)-2,5-Diaminopentanoic acid,L-鸟氨酸盐酸盐;L-2,5-二氨基戊酸盐酸盐;L-鸟氨酸单盐酸盐;鸟氨酸盐酸盐;L-盐酸鸟氨酸;L-鸟粪氨基酸盐酸盐	Others; Endogenous Metabolite	Metabolism; Others
	L-Ornithine hydrochloride ((S)-2,5-Diaminopentanoic acid) 通过提高能量消耗效率和促进氨的排泄而具有抗疲劳作用。它是尿素循环中的关键反应物之一。
T0326L	L-Glutamine L-Glutamic acid 5-amide,L-谷氨酰胺	Ferroptosis; Endogenous Metabolite; GluR	Apoptosis; Metabolism; Neuroscience
	L-Glutamine (L-Glutamic acid 5-amide) 是在人体中大量存在的一种非必需氨基酸，由谷氨酸和氨合成。它为某些细胞中的氧化提供了碳源。
T0738	Urea 尿素,Ureophil,Carbamide,E-Cardamoni,Carbonyldiamide	Others; DHFR; Wnt/beta-catenin; Arginase; Endogenous Metabolite; Carbonic Anhydrase	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Others; Stem Cells
	Urea (Carbonyldiamide) 在肝脏中由氨基酸脱氨产生的氨形成。它是蛋白质分解代谢的主要终代谢产物。
T2O2774	L-Asparagine alpha-aminosuccinamic acid,L-天门冬氨酸,(-)-Asparagine,Asparamide,2-Aminosuccinamic acid,Asn,Altheine	Endogenous Metabolite	Metabolism
	L-Asparagine (Asparamide) 是一种非必需氨基酸，可以参与神经和脑组织细胞功能的代谢控制。
T0326	DL-Glutamine Glutamin,DL-Gl,(±)-Glutamine,DL-谷氨酰胺,2-amino-4-carbamoylbutanoic acid	Ferroptosis; Amino Acids and Derivatives; Endogenous Metabolite	Apoptosis; Metabolism
	DL-Glutamine (2-amino-4-carbamoylbutanoic acid) 是一种非必需氨基酸，大量存在于全身并参与许多代谢过程。它由谷氨酸和氨合成，是体内氮的主要载体，是许多细胞的重要能量来源，用于制药和供生物化学研究。
T5267	N-Acetyl-L-glutamic acid Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) 是一种 N-Acyl-L-氨基酸，是动物细胞培养基的组成成分，是一种酿酒酵母和人类的代谢物。
T4826	L-Histidine monohydrochloride monohydrat	Others; Endogenous Metabolite	Metabolism; Others
	L-Histidine monohydrochloride monohydrat 是一种 α-氨基酸。 L-异构体是 22 种蛋白质氨基酸之一，即蛋白质的组成部分。
T20262	Arginine glutamate Modumate,NSC-122009,NSC 122009,NSC122009,NCI-C02120,Argimate
	Arginine glutamate is an agent of ammonia Detoxicant.

天然产物

2-Propen-1-one, 1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-

Cat.No: TN7125

Target: Others

Cat.No: T0737

Synonym: (S)-2,5-Diaminopentanoic acid,L-鸟氨酸,鸟氨酸

Target: Decarboxylase, Amino Acids and Derivatives, Arginase, Endogenous Metabolite

L-Ornithine hydrochloride

Cat.No: T2O2701

Synonym: L(+)-Ornithine hydrochloride,(S)-2,5-Diaminopentanoic acid,L-鸟氨酸盐酸盐;L-2,5-二氨基戊酸盐酸盐;L-鸟氨酸单盐酸盐;鸟氨酸盐酸盐;L-盐酸鸟氨酸;L-鸟粪氨基酸盐酸盐

Target: Others, Endogenous Metabolite

Cat.No: T0326L

Synonym: L-Glutamic acid 5-amide,L-谷氨酰胺

Target: Ferroptosis, Endogenous Metabolite, GluR

Cat.No: T0738

Synonym: 尿素,Ureophil,Carbamide,E-Cardamoni,Carbonyldiamide

Target: Others, DHFR, Wnt/beta-catenin, Arginase, Endogenous Metabolite, Carbonic Anhydrase

Cat.No: T2O2774

Synonym: alpha-aminosuccinamic acid,L-天门冬氨酸,(-)-Asparagine,Asparamide,2-Aminosuccinamic acid,Asn,Altheine

Target: Endogenous Metabolite

Cat.No: T0326

Synonym: Glutamin,DL-Gl,(±)-Glutamine,DL-谷氨酰胺,2-amino-4-carbamoylbutanoic acid

Target: Ferroptosis, Amino Acids and Derivatives, Endogenous Metabolite

N-Acetyl-L-glutamic acid

Cat.No: T5267

Synonym: Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid

Target: Others, Endogenous Metabolite

L-Histidine monohydrochloride monohydrat

Cat.No: T4826

Target: Others, Endogenous Metabolite

Arginine glutamate

Cat.No: T20262

Synonym: Modumate,NSC-122009,NSC 122009,NSC122009,NCI-C02120,Argimate

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