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Cat. No.	Product Name	Target	Signaling Pathways
T40255	VCP/p97 inhibitor-1 VCP/p97 inhibitor-1
	VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degradation process of misfolded polypeptides by the ubiquitin-proteasome system (UPS).
T18871	VCP-Eribulin	Others	Others
	VCP-Eribulin, an Eribulin-based drug for antibody conjugates[1], combines the VCP (ADCs linker) with Eribulin, a distinct microtubule inhibitor used in cancer treatments[2].
T18278	Mal-PEG2-VCP-Eribulin	Others	Others
	Mal-PEG2-VCP-Eribulin is a chemotherapeutic compound comprising an antibody-drug conjugate (ADC) linker (Mal-PEG2-VCP) and the microtubule inhibitor Eribulin[1]. This compound uniquely targets microtubules, offering a novel approach to cancer treatment. Eribulin is specifically utilized in creating targeted Eribulin-based drugs for antibody conjugates[1].
T18279	Mal-PEG2-VCP-NB	Others	Others
	Mal-PEG2-VCP-NB is a nonclaevable ADC linker containing a Maleimide group, 2-unit PEG and a VCP NB.
T70421	VCP746
	VCP-746 is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling. VCP746 reduces hypertrophy in a rat neonatal cardiac myocyte model. VCP746 is a hybrid molecule consisting of an adenosine moiety linked to an adenosine A1 receptor (A1AR) allosteric modulator moiety. At the A1AR, VCP746 mediated cardioprotection in the absence of haemodynamic side effects such as bradycardia.
T3535	ML240	p97	Ubiquitination
	ML240 是一种选择性的 ATP 竞争性 p97 抑制剂，IC50值为 100 nM。
T1853	NMS-873	p97	Ubiquitination
	NMS873 是一种有效的选择性变构 VCP/p97 抑制剂，IC50值为 30 nM。
T9008	NPD8733	Others	Others
	NPD8733 是癌细胞增强的成纤维细胞迁移抑制剂。它是与多种细胞活动 (AAA+) 蛋白家族相关的 ATP 酶的成员，能够与含 valosin 的蛋白 (VCP)/p97特异性结合，对癌症疾病具有潜在的研究价值。
T1969	DBEQ JRF 12	Apoptosis; p97; Autophagy	Apoptosis; Autophagy; Ubiquitination
	DBEQ (JRF 12) 是一种选择性的，ATP 竞争性p97抑制剂，对 p97(wt) 和 p97(C522A) 的IC50值分别为 1.5 μM 和 1.6 μM，也可抑制Vps4，IC50值为 11.5 μM。
T6796	CB-5083 CB5083,CB 5083	p97	Ubiquitination
	CB-5083 是一种有效的、选择性的、可口服的 p97 AAA ATPase 抑制剂，IC50为 11 nM。
T4684	ML241 hydrochloride	p97	Ubiquitination
	ML241 hydrochloride 是一种有效且选择性的 p97 ATPase 抑制剂，IC50值为 100 nM。
T29112	VPC171 (2-氨基-4-(3-(三氟甲基)苯基)噻吩-3-基)(苯基)甲酮,VPC 171,VPC-171	Adenosine Receptor	GPCR/G Protein; Neuroscience
	VPC171 是一种新型腺苷 A1 受体正变构调节剂 (PAM)。
T71930	aPKC-I
	aPKC-I is an inhibitor of atypical protein kinase C (aPKC ) which inhibits both PKCζ and PKCι with high specificity and prevents VEGF-induced endothelial permeability in cell culture and in vivo, thereby blocking ischemia-reperfusion (IR)-induced permeability.
T31567	Doxorubicin-MVCP MC-Val-Cit-PAB-Doxorubicin,MC-Val-Cit-PAB-Dox
	Doxorubicin-MVCP (MC-Val-Cit-PAB-Doxorubicin) is a Doxorubicin derivative with an MC-Val-Cit-PAB linker.
T33861	Paclitaxel-MVCP
	Paclitaxel-MVCP ( MC-val-cit-pab-paclitaxel )is a paclitaxel derivative with an MC-Val-Cit-PAB linker, which can be used for the preparation of Paclitaxel conjugates for drug delivery and nanomedicine research.
T12236	NMS-859 ZINC169324353	Others	Others
	NMS-859 是一种有效的含 valosin 蛋白 (VCP)/p97 的共价抑制剂，在细胞中存在 60 μM 和 1 mM ATP 的情况下，对野生型 VCP 的 IC50 分别为 0.37 μM 和 0.36 μM。
T62148	NW 1028
	NW 1028 是一种 VCP/p97 的有效抑制剂。NW 1028 能够选择性作用于 p97 的 ND1L 结构域，抑制依赖于 p97 的报告基因的降解。NW 1028 能够良好的结合 ND1L (Kd: 100 nM) 和全长 p97 (Kd: 285 nM)。NW 1028 对细胞有丝分裂纺锤体具有调节作用。
T36570	KUS121
	KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, an inducer of ER stress, in HeLa cells when used at concentrations of 20, 50, and 50 μM, respectively. KUS121 (100 μM) inhibits ATP depletion and cell death induced by oxygen-glucose deprivation (OGD) in rat primary cortical neurons in anin vitromodel of cerebral ischemia.2It red...

化合物

VCP/p97 inhibitor-1

Cat.No: T40255

Synonym: VCP/p97 inhibitor-1

Cat.No: T18871

Target: Others

Mal-PEG2-VCP-Eribulin

Cat.No: T18278

Target: Others

Mal-PEG2-VCP-NB

Cat.No: T18279

Target: Others

Cat.No: T70421

Cat.No: T3535

Target: p97

Cat.No: T1853

Target: p97

Cat.No: T9008

Target: Others

Cat.No: T1969

Synonym: JRF 12

Target: Apoptosis, p97, Autophagy

Cat.No: T6796

Synonym: CB5083,CB 5083

Target: p97

ML241 hydrochloride

Cat.No: T4684

Target: p97

Cat.No: T29112

Synonym: (2-氨基-4-(3-(三氟甲基)苯基)噻吩-3-基)(苯基)甲酮,VPC 171,VPC-171

Target: Adenosine Receptor

Cat.No: T71930

Doxorubicin-MVCP

Cat.No: T31567

Synonym: MC-Val-Cit-PAB-Doxorubicin,MC-Val-Cit-PAB-Dox

Paclitaxel-MVCP

Cat.No: T33861

Cat.No: T12236

Synonym: ZINC169324353

Target: Others

Cat.No: T62148

Cat.No: T36570

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