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18

抑制剂 & 化合物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T40255	VCP/p97 inhibitor-1 VCP/p97 inhibitor-1
	VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degradation process of misfolded polypeptides by the ubiquitin-proteasome system (UPS).
T18871	VCP-Eribulin	Others	Others
	VCP-Eribulin, an Eribulin-based drug for antibody conjugates[1], combines the VCP (ADCs linker) with Eribulin, a distinct microtubule inhibitor used in cancer treatments[2].
T18278	Mal-PEG2-VCP-Eribulin	Others	Others
	Mal-PEG2-VCP-Eribulin is a chemotherapeutic compound comprising an antibody-drug conjugate (ADC) linker (Mal-PEG2-VCP) and the microtubule inhibitor Eribulin[1]. This compound uniquely targets microtubules, offering a novel approach to cancer treatment. Eribulin is specifically utilized in creating targeted Eribulin-based drugs for antibody conjugates[1].
T18279	Mal-PEG2-VCP-NB	Others	Others
	Mal-PEG2-VCP-NB is a nonclaevable ADC linker containing a Maleimide group, 2-unit PEG and a VCP NB.
T70421	VCP746
	VCP-746 is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling. VCP746 reduces hypertrophy in a rat neonatal cardiac myocyte model. VCP746 is a hybrid molecule consisting of an adenosine moiety linked to an adenosine A1 receptor (A1AR) allosteric modulator moiety. At the A1AR, VCP746 mediated cardioprotection in the absence of haemodynamic side effects such as bradycardia.
T3535	ML240	p97	Ubiquitination
	ML240 是一种选择性的 ATP 竞争性 p97 抑制剂，IC50值为 100 nM。
T1853	NMS-873	p97	Ubiquitination
	NMS873 是一种有效的选择性变构 VCP/p97 抑制剂，IC50值为 30 nM。
T9008	NPD8733	Others	Others
	NPD8733 是癌细胞增强的成纤维细胞迁移抑制剂。它是与多种细胞活动 (AAA+) 蛋白家族相关的 ATP 酶的成员，能够与含 valosin 的蛋白 (VCP)/p97特异性结合，对癌症疾病具有潜在的研究价值。
T1969	DBEQ JRF 12	Apoptosis; p97; Autophagy	Apoptosis; Autophagy; Ubiquitination
	DBEQ (JRF 12) 是一种选择性的，ATP 竞争性p97抑制剂，对 p97(wt) 和 p97(C522A) 的IC50值分别为 1.5 μM 和 1.6 μM，也可抑制Vps4，IC50值为 11.5 μM。
T4684	ML241 hydrochloride	p97	Ubiquitination
	ML241 hydrochloride 是一种有效且选择性的 p97 ATPase 抑制剂，IC50值为 100 nM。
T6796	CB-5083 CB5083,CB 5083	p97	Ubiquitination
	CB-5083 是一种有效的、选择性的、可口服的 p97 AAA ATPase 抑制剂，IC50为 11 nM。
T29112	VPC171 (2-氨基-4-(3-(三氟甲基)苯基)噻吩-3-基)(苯基)甲酮,VPC 171,VPC-171	Adenosine Receptor	GPCR/G Protein; Neuroscience
	VPC171 是一种新型腺苷 A1 受体正变构调节剂 (PAM)。
T71930	aPKC-I
	aPKC-I is an inhibitor of atypical protein kinase C (aPKC ) which inhibits both PKCζ and PKCι with high specificity and prevents VEGF-induced endothelial permeability in cell culture and in vivo, thereby blocking ischemia-reperfusion (IR)-induced permeability.
T31567	Doxorubicin-MVCP MC-Val-Cit-PAB-Doxorubicin,MC-Val-Cit-PAB-Dox
	Doxorubicin-MVCP (MC-Val-Cit-PAB-Doxorubicin) is a Doxorubicin derivative with an MC-Val-Cit-PAB linker.
T33861	Paclitaxel-MVCP
	Paclitaxel-MVCP ( MC-val-cit-pab-paclitaxel )is a paclitaxel derivative with an MC-Val-Cit-PAB linker, which can be used for the preparation of Paclitaxel conjugates for drug delivery and nanomedicine research.
T12236	NMS-859 ZINC169324353	Others	Others
	NMS-859 是一种有效的含 valosin 蛋白 (VCP)/p97 的共价抑制剂，在细胞中存在 60 μM 和 1 mM ATP 的情况下，对野生型 VCP 的 IC50 分别为 0.37 μM 和 0.36 μM。
T62148	NW 1028
	NW 1028 是一种 VCP/p97 的有效抑制剂。NW 1028 能够选择性作用于 p97 的 ND1L 结构域，抑制依赖于 p97 的报告基因的降解。NW 1028 能够良好的结合 ND1L (Kd: 100 nM) 和全长 p97 (Kd: 285 nM)。NW 1028 对细胞有丝分裂纺锤体具有调节作用。
T36570	KUS121
	KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, an inducer of ER stress, in HeLa cells when used at concentrations of 20, 50, and 50 μM, respectively. KUS121 (100 μM) inhibits ATP depletion and cell death induced by oxygen-glucose deprivation (OGD) in rat primary cortical neurons in anin vitromodel of cerebral ischemia.2It red...

化合物

VCP/p97 inhibitor-1

Cat.No: T40255

Synonym: VCP/p97 inhibitor-1

Cat.No: T18871

Target: Others

Mal-PEG2-VCP-Eribulin

Cat.No: T18278

Target: Others

Mal-PEG2-VCP-NB

Cat.No: T18279

Target: Others

Cat.No: T70421

Cat.No: T3535

Target: p97

Cat.No: T1853

Target: p97

Cat.No: T9008

Target: Others

Cat.No: T1969

Synonym: JRF 12

Target: Apoptosis, p97, Autophagy

ML241 hydrochloride

Cat.No: T4684

Target: p97

Cat.No: T6796

Synonym: CB5083,CB 5083

Target: p97

Cat.No: T29112

Synonym: (2-氨基-4-(3-(三氟甲基)苯基)噻吩-3-基)(苯基)甲酮,VPC 171,VPC-171

Target: Adenosine Receptor

Cat.No: T71930

Doxorubicin-MVCP

Cat.No: T31567

Synonym: MC-Val-Cit-PAB-Doxorubicin,MC-Val-Cit-PAB-Dox

Paclitaxel-MVCP

Cat.No: T33861

Cat.No: T12236

Synonym: ZINC169324353

Target: Others

Cat.No: T62148

Cat.No: T36570

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01013	VCP Protein, Human, Recombinant (His) TER ATPase,Transitional Endoplasmic Reticulum ATPase,15S Mg(...	Human	E. coli
	Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin...
TMPH-01909	CPVL Protein, Human, Recombinant (His & SUMO) Carboxypeptidase, vitellogenic-like,VCP-like protei...	Human	E. coli
	CPVL Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-02828	PLAA Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus
	Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tu...
TMPH-01259	AMFR Protein, Human, Recombinant (His) Autocrine motility factor receptor,AMF receptor,gp78,RNF45,R...	Human	E. coli
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add...
TMPH-01260	AMFR Protein, Human, Recombinant (hFc) gp78,RNF45,AMF receptor,RING finger protein 45,E3 ubiquitin-...	Human	HEK293
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add...
TMPH-02178	TARDBP Protein, Human, Recombinant	Human	E. coli
	RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitoch...
TMPH-02179	TARDBP Protein, Human, Recombinant (His)	Human	Yeast
	RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitoch...
TMPH-02282	Ubiquilin-1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its in...
TMPH-01270	TRAIP Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm...
TMPH-02632	TRIM21 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...
TMPH-02633	TRIM21 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...

重组蛋白

VCP Protein, Human, Recombinant (His)

Cat.No: TMPJ-01013

Species: Human

Expression System: E. coli

CPVL Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01909

Species: Human

Expression System: E. coli

PLAA Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02828

Species: Mouse

Expression System: Baculovirus

AMFR Protein, Human, Recombinant (His)

Cat.No: TMPH-01259

Species: Human

Expression System: E. coli

AMFR Protein, Human, Recombinant (hFc)

Cat.No: TMPH-01260

Species: Human

Expression System: HEK293

TARDBP Protein, Human, Recombinant

Cat.No: TMPH-02178

Species: Human

Expression System: E. coli

TARDBP Protein, Human, Recombinant (His)

Cat.No: TMPH-02179

Species: Human

Expression System: Yeast

Ubiquilin-1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02282

Species: Human

Expression System: E. coli

TRAIP Protein, Human, Recombinant (His)

Cat.No: TMPH-01270

Species: Human

Expression System: E. coli

TRIM21 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02632

Species: Mouse

Expression System: E. coli

TRIM21 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02633

Species: Mouse

Expression System: Baculovirus

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