Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7694 |
6-fluoro-DL-Tryptophan
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
6-fluoro-DL-Tryptophan 是血清素 (5-HT) 合成的抑制剂。 | |||
T21506 |
Telotristat
|
Hydroxylase | Metabolism |
Telotristat 是色氨酸羟化酶 (tryptophan hydroxylase) 抑制剂,在体内的IC50值为0.028 μM。 | |||
T15796 |
LX-1031
|
Hydroxylase; LPA Receptor | GPCR/G Protein; Metabolism |
LX-1031 是一种有效的色氨酸 5-羟化酶抑制剂。 LX-1031 减少外周5-羟色胺的合成。 | |||
T14119 |
ACT-678689
Compound Example 1.53.4 |
Hydroxylase | Metabolism |
ACT-678689 (Compound Example 1.53.4) 是一种色氨酸羟化酶 (TPH) 抑制剂,IC50=8 nM。 | |||
T11897 |
Telotristat ethyl
LX1606 |
Hydroxylase | Metabolism |
Telotristat ethyl (LX1606) 是一种口服具有活力的色氨酸羟化酶抑制剂,可抑制血清素的产生。 | |||
T10142L |
p-Ethynylphenylalanine hydrochloride
4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base) |
Hydroxylase | Metabolism |
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) 是一种高效的、可逆的、选择性的、竞争性的色氨酸羟化酶 (TPH) 抑制剂,其Ki=32.6 μM。 | |||
T6044 |
Telotristat Etiprate
LX1606 (Hippurate),LX 1606 Hippurate,特罗司他马尿酸盐 |
Hydroxylase | Metabolism |
Telotristat Etiprate (LX 1606 Hippurate) 是一种色氨酸羟化酶抑制剂,可抑制血清素的产生。 | |||
T1447 |
Fenclonine
Fenchlonine,PCPA,CP-10188,芬克洛宁,4-Chloro-DL-phenylalanine,DL-4-Chlorophenylalanine |
Hydroxylase | Metabolism |
Fenclonine (CP-10188) 是一种有效的色氨酸羟化酶(Trp)的不可逆抑制剂。其中色氨酸羟化酶是 5-羟色胺生物合成的限速酶。 | |||
T41143 |
pCPA methyl ester hydrochloride
4-氯-DL-苯基丙氨酸甲酯盐酸盐,4-Chloro-DL-phenylalanine methyl ester hydrochloride |
5-HT Receptor; Hydroxylase | GPCR/G Protein; Metabolism; Neuroscience |
pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) 是色氨酸羟化酶抑制剂和5-HT 合成的抑制剂。 pCPA methyl ester hydrochloride 可穿过血脑屏障并降低 5-HT 中枢可用性。 | |||
T10142 |
p-Ethynylphenylalanine
4-Ethynyl-L-phenylalanine |
Others; Hydroxylase | Metabolism; Others |
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一种色氨酸羟化酶(TPH)抑制剂,具有竞争性、有效性、选择性和可逆性,Ki 为32.6 μM。 | |||
T16780 |
Rodatristat
KAR5417 |
Others | Others |
Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively). | |||
T26258 |
Telotristat besilate
|
||
Telotristat besilate is an inhibitor of tryptophan hydroxylase. | |||
T15778 |
LP-533401
|
Hydroxylase | Metabolism |
LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut. | |||
T69135 | AGN-2979 | ||
AGN-2979 is a tryptophan hydroxylase (TPH) activation inhibitor that shows antidepressant properties in rodent models of depression. | |||
T71888 | Fenclonine hydrochloride | ||
Fenclonine hydrochloride is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin. | |||
T16779 |
Rodatristat ethyl
RVT-014,KAR5585,RVT-1201 |
5-HT Receptor; Hydroxylase | GPCR/G Protein; Metabolism; Neuroscience |
Rodatristat ethyl (KAR5585) 是一种首新型具有口服活性和有效性的 tryptophan hydroxylase 1 (TPH1) 抑制剂,低浓度下可显著降低 5-hydroxytryptamine (5-HT) 的水平并降低肺动脉高压 (PAH), | |||
T78228 |
4-Chloro-L-phenylalanine
L-4-Chlorophenylalanine,L-PCPA |
5-HT Receptor | GPCR/G Protein; Neuroscience |
4-Chloro-L-phenylalanine (L-PCPA) 是一种 5-HT 生物合成抑制剂。4-Chloro-L-phenylalanine 也是色氨酸羟化酶(TPH1 和 TPH2)的非特异性拮抗剂。 | |||
T79712 |
TPH1-IN-1
|
||
TPH1-IN-1(compound 40),一种黄嘌呤衍生物,作为色氨酸羟化酶TPH1的抑制剂,显示出110.1 nM的IC50值。该化合物展现了优异的体外活性以及在肝微粒体中的稳定性,并且能有效抑制T3-L1细胞的脂肪细胞分化。 |