Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ACT-678689 (Compound Example 1.53.4) 是一种色氨酸羟化酶 (TPH) 抑制剂,IC50=8 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,530 | 现货 | ||
5 mg | ¥ 3,160 | 现货 | ||
10 mg | ¥ 4,630 | 现货 | ||
25 mg | ¥ 7,330 | 现货 | ||
50 mg | ¥ 9,890 | 现货 | ||
100 mg | ¥ 13,300 | 现货 | ||
500 mg | ¥ 26,700 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,950 | 现货 |
产品描述 | ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1]. |
靶点活性 | TPH:8 nM |
体外活性 | TPH comprises two isoforms: TPH1 and TPH2. TPH1 is mainly expressed in peripheral tissues, including the entrochromaffin cells (EC) in the gut, where it is responsible for synthesizing 5HT that is stored in circulating blood platelets[1]. TPH2 is mainly expressed in neuronal cell types in the central nervous system (CNS). |
别名 | Compound Example 1.53.4 |
分子量 | 565.04 |
分子式 | C23H22ClFN6O4S2 |
CAS No. | 1783256-96-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (212.37 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7698 mL | 8.8489 mL | 17.6979 mL | 44.2447 mL |
5 mM | 0.354 mL | 1.7698 mL | 3.5396 mL | 8.8489 mL | |
10 mM | 0.177 mL | 0.8849 mL | 1.7698 mL | 4.4245 mL | |
20 mM | 0.0885 mL | 0.4424 mL | 0.8849 mL | 2.2122 mL | |
50 mM | 0.0354 mL | 0.177 mL | 0.354 mL | 0.8849 mL | |
100 mM | 0.0177 mL | 0.0885 mL | 0.177 mL | 0.4424 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ACT-678689 1783256-96-1 Metabolism Hydroxylase Tryptophan Hydroxylase Inhibitor ACT 678689 ACT678689 Compound Example 1.53.4 inhibit inhibitor