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Search Results for " tromethamine "

15

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4546	Dinoprost tromethamine salt Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,地诺前列素氨丁三醇,Prostaglandin F2α THAM	Apoptosis; Endogenous Metabolite; Prostaglandin Receptor; Autophagy; PROTAC Linker	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; PROTAC
	Dinoprost tromethamine salt (PGF2α THAM) 是一种口服有效的前列腺素 F 受体激动剂。它是在子宫内膜腔上皮和黄体中局部产生的溶酶激素，在分娩过程中起关键作用。
T25986	Prinomide tromethamine	Others	Others
	Prinomide tromethamine 是一种抗风湿病的化合物。
T4989	Fosfomycin Tromethamine	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin tromethamine 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药细菌。
T15772	Lodoxamide tromethamine U-42585E	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Lodoxamide tromethamine 是一种的肥大细胞稳定剂，具有抗过敏特性，可用于治疗哮喘和过敏性结膜炎的研究。
T1212	Ketorolac tromethamine salt 酮咯酸氨丁三醇,Acular LS,Toradol,Ketorolac tris salt,Acular	COX	Immunology/Inflammation; Neuroscience
	Ketorolac tromethamine salt (Ketorolac tris salt) 是一种非甾体抗炎剂，是非选择性的 COX 抑制剂，对 COX-1 和 COX-2 的IC50值分别为 20 和 120 nM。
T71500	Palifosfamide tromethamine IPM tromethamine,Isophosphoramide mustard tromethamine,ZIO-201 tromethamine,Isophosphoramide mustard tromethamine ; IPM tromethamine ; ZIO-201 tromethamine
	Palifosfamide (tromethamine) 是一种具有潜在抗肿瘤活性的合成烷基化剂。作为异环磷酰胺 (ifosfamide) 稳定的活性代谢物，Palifosfamide (tromethamine) 通过GC 碱基对不可逆地烷基化和交联DNA，导致了DNA 复制的抑制，并导致细胞死亡。与异环磷酰胺相比，Palifosfamide (tromethamine)的毒性较小。
T0961	Trometamol 三(羟甲基)氨基甲烷,Tromethamine,缓血酸铵	COX	Immunology/Inflammation; Neuroscience
	Trometamol (Tromethamine) 是一种在生理范围内控制 pH 值的有效胺类化合物，也是一种低毒性的生物惰性氨基醇，可以在体内和体外缓冲二氧化碳和酸。
T25929	Pemetrexed tromethamine Pemetrexed ditromethamine dihydrate
	Pemetrexed tromethamine is a chemotherapy drug used for pleural mesothelioma and non-small cell lung cancer.
T72146	Loxoprofenol-SRS tromethamine HR1405–01
	Loxoprofenol-SRS tromethamine (HR1405-01) 为Loxoprofen的活性代谢物，为一种可静脉注射的安全非甾体抗炎药(NSAID)，展现出良好的抗炎及镇痛效果。
T75430	Succinic acid tromethamine
	Succinic acid tromethamine 是一种口服活性抗焦虑剂，有效地参与三羧酸循环作为中间产物。它也广泛用作食品、化学和制药行业中多种重要工业化学品的前体。
T69724	Cilofexor tromethamine
	Cilofexor, also known as GS-9674, is a farnesoid X receptor (FXR) agonist. The nonsteroidal FXR agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with PSC. In clinical study, cilofexor was well tolerated and led to significant improvements in liver biochemistries and markers of cholestasis in patients with PSC.
T23478	Trometamol hydrochloride TRIS hydrochloride,三(羟甲基)氨基甲烷盐酸盐	Others	Others
	Trometamol hydrochloride (TRIS hydrochloride) 是低毒性的生物惰性氨基醇，可以在体内、外缓冲二氧化碳和酸，能用于生理范围内控制 pH 值。
T69723	Taminadenant mesylate
	Taminadenant, also known as PBF-509 and NIR-178, is a potent and orally active adenosine A2A receptor antagonist with potential antineoplastic activity. PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell sur...
T75326	ATP ditromethamine
	ATP ditromethamine（Adenosine 5'-triphosphate ditromethamine）作为体内能量储存和代谢的核心物质，不仅为代谢过程提供必需能量，而且在细胞中担任辅酶角色。此外，它在免疫和炎症反应中，扮演着关键的内源性信号分子角色。
T38196	Prostaglandin F2α isopropyl ester Prostaglandin F2α isopropyl ester
	PGF2α isopropyl ester is an ester prodrug of PGF2α with enhanced lipid solubility. Due to better membrane penetration, PGF2α isopropyl ester is more suitable than PGF2α or PGF2α tromethamine salt for topical application in studies on intraocular pressure. The ester functionality is readily hydrolyzed in vivo to release the active compound PGF2α. When administered topically to the eyes of cynomolgus monkeys, a 5 μg dose reduces intraocular pressure by 68% after the fourth day of treatment.

化合物

Dinoprost tromethamine salt

Cat.No: T4546

Synonym: Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,地诺前列素氨丁三醇,Prostaglandin F2α THAM

Target: Apoptosis, Endogenous Metabolite, Prostaglandin Receptor, Autophagy, PROTAC Linker

Prinomide tromethamine

Cat.No: T25986

Target: Others

Fosfomycin Tromethamine

Cat.No: T4989

Target: Antibacterial, Antibiotic

Lodoxamide tromethamine

Cat.No: T15772

Synonym: U-42585E

Target: Histamine Receptor

Ketorolac tromethamine salt

Cat.No: T1212

Synonym: 酮咯酸氨丁三醇,Acular LS,Toradol,Ketorolac tris salt,Acular

Target: COX

Palifosfamide tromethamine

Cat.No: T71500

Synonym: IPM tromethamine,Isophosphoramide mustard tromethamine,ZIO-201 tromethamine,Isophosphoramide mustard tromethamine ; IPM tromethamine ; ZIO-201 tromethamine

Cat.No: T0961

Synonym: 三(羟甲基)氨基甲烷,Tromethamine,缓血酸铵

Target: COX

Pemetrexed tromethamine

Cat.No: T25929

Synonym: Pemetrexed ditromethamine dihydrate

Loxoprofenol-SRS tromethamine

Cat.No: T72146

Synonym: HR1405–01

Succinic acid tromethamine

Cat.No: T75430

Cilofexor tromethamine

Cat.No: T69724

Trometamol hydrochloride

Cat.No: T23478

Synonym: TRIS hydrochloride,三(羟甲基)氨基甲烷盐酸盐

Target: Others

Taminadenant mesylate

Cat.No: T69723

ATP ditromethamine

Cat.No: T75326

Prostaglandin F2α isopropyl ester

Cat.No: T38196

Synonym: Prostaglandin F2α isopropyl ester

Cat. No.	Product Name	Target	Signaling Pathways
T14865	Carboprost tromethamine	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Carboprost tromethamine 是合成的前列腺素 F2α的15-甲基类似物，能有效促进子宫的规律收缩，显着减少产中及产后出血量。

天然产物

Carboprost tromethamine

Cat.No: T14865

Target: Prostaglandin Receptor

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