Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0675 |
Topiramate
RWJ 17021,McN 4853,托吡酯 |
Potassium Channel; Calcium Channel; GABA Receptor; Sodium Channel; GluR; Carbonic Anhydrase; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Topiramate (RWJ 17021) 是一种GluR5受体拮抗剂,可通过增强GABAergic 活性,抑制kainate/AMPA 受体,抑制钠和钙通道的电压敏感,增加钾电导并抑制碳酸酐酶来产生抗癫痫作用,用于治疗部分性和全身性癫痫发作。 | |||
T13185 |
Topiramate D12
RWJ 17021 D12,McN 4853 D12 |
Others | Others |
Topiramate D12 is a deuterium labeled Topiramate. Topiramate is an agent of broad-spectrum antiepileptic. Topiramate is an antagonist of GluR5 receptor. | |||
T61145 | Topiramate lithium | ||
Topiramate lithium (McN 4853) is a wide-ranging antiepileptic compound with GluR5 receptor antagonistic properties. Its mechanism of action involves enhancing GABAergic activity, inhibiting kainate/AMPA receptors, voltage-sensitive sodium and calcium channels, and increasing potassium conductance. Additionally, this compound inhibits carbonic anhydrase. [1][2][3] | |||
T27673 |
JNJ-26990990
|
Others | Others |
JNJ-26990990 是一种广谱抗惊厥药,是上市药物托吡酯的第二代后续药物。它被设计成具有与托吡酯相同的抗惊厥作用,但没有与托吡酯的碳酸酐酶抑制相关的副作用。它还具有治疗炎症性疼痛、神经性疼痛和抑郁症的潜在用途。 |