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Cat. No. | Product Name | Target | Signaling Pathways |
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T41246 | Thromboxane B2 | ||
Thromboxane B2 是一种在过敏反应期间释放的前列腺素衍生物。Thromboxane B2 诱导动脉收缩和血小板聚集。 | |||
T67959 |
Pirodomast
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Thrombin; Serine Protease | Proteases/Proteasome |
Pirodomast 是血栓素 A(TXA2)合成酶抑制剂。Pirodomast 能抑制白三烯(LT)D4、C4、E4 的形成和血栓素 B2(TXB2)的活性,但对组胺、甲氧胆碱、血清素、LTC4 或血小板活化因子诱导的豚鼠支气管痉挛的拮抗作用较弱或无效。Pirodomast 在体外对豚鼠气管只有微弱的松弛活性。Pirodomast 是一种潜在的抗过敏化合物,在体外可抑制胰蛋白酶的蛋白水解活性,在体内可阻止抗原诱发过敏绵羊的即时和晚期哮喘反应,抑制抗原诱导的过敏绵羊对组胺和卡巴胆碱的气道高反应性。 | |||
T34862 |
Thromboxane A2
Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2 |
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Thromboxane A2, as an unstable intermediate between the prostaglandin endoperoxides and thromboxane B2, is a potent inducer of platelet aggregation and causes vasoconstriction. | |||
T25592 |
Labdane F2
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Labdane F2 is an antagonist of thromboxane B2 and leukotriene B4 isolated from the Spanish herb Sideritis javalambrensis. | |||
T11755 |
KF 13218
|
Histone Demethylase | Chromatin/Epigenetic |
KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM. | |||
T10054 | CI-949 | Others | Others |
CI-949 is an allergic mediator release inhibitor, which inhibits leukotriene C4/D4 (LTC4/LTD4), histamine, and thromboxane B2 (TXB2) release (IC50s: 0.5 μM, 11.4 μM and 0.1 μM). | |||
T36220 |
2,3-dinor Thromboxane B1
2,3-dinor Thromboxane B1 |
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Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2. However in human urine, only trace amounts of 2,3-dinor TXB1 have been identified. In rats, 2,3-dinor TXB1 is excreted at a much higher rate than 2,3-dinor TXB2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively). Therefore, urinary 2,3-... | |||
T37383 |
1,2,3-Trilinoelaidoyl-rac-glycerol
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1,2,3-Trilinoelaidoyl-rac-glycerol is a triacylglycerol that contains linoelaidic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trilinoelaidoyl-rac-glycerol (0.6-6.3% w/w) lowers serum levels of thromboxane B2 , prostaglandin F2 (PGF2), and PGE in rats.1 |1. Bruckner, G., Goswami, S., and Kinsella, J.E. Dietary trilinoelaidate: Effects on organ fatty acid composition, prostanoid biosynthesis and platelet function in rats. J. Nutr. 114(1), 58-67 (1984). | |||
T71212 |
Lornoxicam-d4
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Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e... | |||
T83662 |
2,3-dinor-8-iso Prostaglandin F1α
2,3-dinor-8-iso PGF1α,2,3-dinor-iPF1α-III,2,3-dinor-5,6-dihydro-15-F2t-Isoprostane,2,3-dinor-5,6-dihydro-15-F2t-IsoP |
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2,3-dinor-8-iso Prostaglandin F1α(2,3-dinor-8-iso PGF1α)是一种异前列腺素和花生四烯酸的活性代谢物,也是血小板聚集抑制剂8-iso PGF2α的产物。它通过花生四烯酸的非酶促自由基过氧化作用形成。2,3-dinor-8-iso PGF1α在孤立的猪视网膜和大脑微血管中引起血管收缩(EC50s分别为12.8和18.5 nM),但在31 µM的浓度下使用时不会引起孤立的大鼠主动脉环的收缩。在1 µM的浓度下使用时,它能增加孤立的猪大脑切片中的血栓素B2(TXB2)水平,这一效应可以通过血栓素A合成酶抑制剂CGS 12970、电压门控钙通道抑制剂SKF 96365或烟碱型乙酰胆碱受体(nAChR)拮抗剂α-conotoxin来逆转。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T2964 |
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside
芪多酚,2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside,2,3,5,4'-Tetrahydroxystilbene-2-O-b-D-glucopyranoside,Astragalus polyphenols |
Others | Others |
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Astragalus polyphenols) 是分离自蓼属植物物种的根中,对5-HETE、HHT、thromboxane B2的形成具有抑制作用。 | |||
T7053 |
p-Hydroxycinnamic acid
p-Coumaric acid,p-Cumaric acid,p-Hydroxy-cinnamic acid,对羟基肉桂酸,NSC 59260 |
Thrombin; Endogenous Metabolite; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Proteases/Proteasome |
p-Hydroxycinnamic acid (NSC-59260) 是常见的食用酚,可抑制血小板活性,对血栓素 B2 和前列腺素 E2 的 IC50值分别为 371 和 126 μM。 | |||
TN1957 |
Mulberrofuran Q
MulberrofuranQ |
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Mulberrofuran Q是一种有活性的化合物,可抑制12-羟基-5,8,10-十七碳三烯酸(HHT)和血栓烷B2(环加氧酶产物)的形成 ,可保护神经细胞免受缺氧-缺糖(OGD)诱导的氧化应激的影响。 | |||
T36831 |
9-Oxononanoic Acid
9-ONA |
Phospholipase; CPT | Metabolism |
9-Oxononanoic Acid是一种氧化脂肪酸,由亚油酸自氧化形成,它能提高磷脂酶 A2(PLA2)的活性,并增加离体人体血浆中血栓素 B2 的生成。9-Oxononanoic Acid 能减少肝脏新脂肪酸的合成,并提高大鼠肝脏肉碱棕榈酰转移酶(β-氧化的标志物)的活性。 | |||
TN5939 |
Glutinone
赤杨酮,5-Glutinen-3-one |
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Glutinone (IC50=24 microM) shows a significant effect on thromboxane B2 (TXB2)-release induced by calcium ionophore in human platelets. | |||
TN4586 |
Mulberrofuran A
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COX | Immunology/Inflammation; Neuroscience |
Mulberrofuran A can inhibit the formations of 12-hydroxy-, 8, 10-heptadecatrienoic acid (HHT) and thromboxane B2, but it can increase the formation of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid (12-HETE). |