Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9245 |
TRPM4-IN-1
CBA,4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid |
TRP/TRPV Channel | Membrane transporter/Ion channel |
TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) 是一种有效的阳离子通道TRPM4选择性抑制剂,IC50为 1.5 μM。TRPM4-IN-1 在心脏病和前列腺癌中具有研究价值。 | |||
T9776 |
TRPM4 inhibitor 8
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
TRPM4 inhibitor 8 是瞬态受体电位 melastatin 4 (TRPM4) 的抑制剂,它有助于活力、迁移、细胞周期转变和粘附。 | |||
T72662 | NMDAR/TRPM4-IN-2 | ERK; TRP/TRPV Channel; NMDAR; iGluR | MAPK; Membrane transporter/Ion channel; Neuroscience |
NMDAR/TRPM4-IN-2 是一种有效的 NMDAR/TRPM4 相互作用界面抑制剂。NMDAR/TRPM4-IN-2 保护小鼠免受 MCAO 诱导的脑损伤和 NMDA 诱导的视网膜神经节细胞丢失。NMDAR/TRPM4-IN-2 具有神经保护活性, 可预防 NMDA 诱导的海马神经元细胞死亡和线粒体功能障碍,其 IC50 值为 2.1 μM。 | |||
T61275 |
TRPM4-IN-2
NBA |
TRP/TRPV Channel | Membrane transporter/Ion channel |
TRPM4-IN-2 (NBA), also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4). Its inhibitory potency is represented by an IC 50 value of 0.16 μM. This compound serves as a valuable tool in the investigation of prostate cancer and colorectal cancer [1] [2]. | |||
T22537 |
9-Phenanthrol
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
9-Phenanthrol 是瞬时受体电位 melastatin 4 (TRPM) 通道的抑制剂,这是一种 Ca2+ 激活的非选择性阳离子通道。 | |||
T9263 |
cim0216
N-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)acetamide |
TRP/TRPV Channel | Membrane transporter/Ion channel |
CIM0216 是选择性的TRPM3激动剂,对 TRPM3 的选择性高于 TRPM1、TRPM2 和 TRPM4-8。它以TRPM3依赖性的方式引起疼痛并唤起感觉神经末梢的神经肽释放,可用于神经源性炎症的相关研究。 |