Powder: -20°C for 3 years | In solvent: -80°C for 1 year
9-Phenanthrol 是瞬时受体电位 melastatin 4 (TRPM) 通道的抑制剂,这是一种 Ca2+ 激活的非选择性阳离子通道。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 321 | 现货 | ||
25 mg | ¥ 496 | 现货 | ||
50 mg | ¥ 823 | 现货 | ||
100 mg | ¥ 1,197 | 现货 |
产品描述 | 9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel. |
体外活性 | In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC(50). Channel inhibition was voltage independent. The IC(50) determined in the whole-cell and inside-out experiments were similar, suggesting a direct effect of the molecule. However, 9-phenanthrol was ineffective on TRPM5, the most closely related channel within the TRP protein family. We identify 9-phenanthrol as a TRPM4 inhibitor, without effects on TRPM5. It could be valuable in investigating the physiological functions of TRPM4, as distinct from those of TRPM5[1]. |
分子量 | 194.23 |
分子式 | C14H10O |
CAS No. | 484-17-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 19mg/mL (97.82mM), sonification is recommended.
Ethanol: 9mg/mL (46.34mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 5.1485 mL | 25.7427 mL | 51.4854 mL | 128.7134 mL |
5 mM | 1.0297 mL | 5.1485 mL | 10.2971 mL | 25.7427 mL | |
10 mM | 0.5149 mL | 2.5743 mL | 5.1485 mL | 12.8713 mL | |
20 mM | 0.2574 mL | 1.2871 mL | 2.5743 mL | 6.4357 mL | |
DMSO | 50 mM | 0.103 mL | 0.5149 mL | 1.0297 mL | 2.5743 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
9-Phenanthrol 484-17-3 Membrane transporter/Ion channel TRP/TRPV Channel ischemia-reperfusion injury inhibit TRPM4 NSC-50554 9Phenanthrol Inhibitor NSC 50554 TRP Channel 9-Hydroxyphenanthrene Transient receptor potential channels 9 Phenanthrol NSC50554 inhibitor