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Targets Recommended: TNF

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Cat. No.	Product Name	Target	Signaling Pathways
T76787	Conatumumab TRAIL-R2 mAb,AMG 655	TNF	Apoptosis
	Conatumumab (AMG 655) 是一种靶向人死亡受体 5 (DR5，TRAILR2) 的单克隆激动剂抗体，对长型 DR5 的 Kd 为 1 nM, 对短型 DR5 的 Kd 0.8 nM。Conatumumab 通过半胱天冬酶激活在多种肿瘤类型中诱导细胞凋亡。Conatumumab 可用于研究晚期实体肿瘤。

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Conatumumab

Cat.No: T76787

Synonym: TRAIL-R2 mAb,AMG 655

Target: TNF

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Cat. No.	Product Name	Species	Expression System
TMPY-01185	DR5/TRAIL R2 Protein, Human, Recombinant (His) KILLER,TRICK2A,TRICK2,DR5,TRICKB,tumor necrosis factor recep...	Human	HEK293 Cells
	DR5/TRAIL R2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is O14763-1.
TMPK-00277	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc) TRAIL R2,TNFRSF10B,TRICK2,KILLER,DR5,T...	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
TMPJ-00276	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His) DR5,TRAILR2,TRICK2,TNFRSF10B,KILLER,TNF-Re...	Human	HEK293 Cells
	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His) is expressed in HEK293 mammalian cells with C-Fc-6xHis tag. The predicted molecular weight is 49 KDa and the accession number is O14763.
TMPY-05388	DR5/TRAIL R2 Protein, Human, Recombinant (hFc) tumor necrosis factor receptor superfamily, member 10b,T...	Human	HEK293 Cells
	DR5/TRAIL R2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41 kDa and the accession number is AAB67103.1.
TMPK-00276	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi) ZTNFR9,DR5TRICK2B,DR5,TRAIL receptor 2,TRICKB,TNFRS...	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
TMPJ-00430	TRAIL R2/DR5/TNFRSF10B Protein, Cynomolgus, Recombinant (His) Death Receptor 5,TRAILR2,CD262,DR5,TNFRSF1...	Cynomolgus	HEK293 Cells
	TRAIL R2/DR5/TNFRSF10B Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 22-30 KDa and the accession number is A0A2K5TXK0.
TMPY-05477	DR5/TRAIL R2 Protein, Human, Recombinant (His), Biotinylated DR5,tumor necrosis factor receptor superfamily, member 10b,T...	Human	HEK293 Cells
	DR5/TRAIL R2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.8 kDa and the accession number is O14763-1.
TMPJ-00275	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated DR5,Tumor Necrosis Factor Receptor Superfamily Member 10B,	Human	HEK293 Cells
	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 18-25 KDa and the accession number is O14763.
TMPY-06835	DR5/TRAIL R2 Protein, Human, Recombinant (His & Avi), Biotinylated TRICK2A,DR5,tumor necrosis factor receptor superfamily, memb...	Human	HEK293 Cells
	DR5/TRAIL R2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17.54 kDa and the accession number is NP_003833.4.
TMPY-01437	DR5/TRAIL R2 Protein, Mouse, Recombinant (His) TRAILR2,MK,TRICKB,TRICK2B,TRICK2A,Ly98,DR5...	Mouse	HEK293 Cells
	DR5/TRAIL R2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is Q9QZM4.
TMPJ-00246	TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc) MK,CD262,Tnfrsf10b,Dr5,Tumor necrosis factor receptor superf...	Mouse	HEK293 Cells
	TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 50-75 KDa and the accession number is Q9QZM4.
TMPY-01452	DR5/TRAIL R2 Protein, Mouse, Recombinant (His & hFc) TRICK2B,DR5,tumor necrosis factor receptor superfamily, memb...	Mouse	HEK293 Cells
	DR5/TRAIL R2 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 41.8 kDa and the accession number is Q9QZM4.
TMPJ-00245	TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (Avi & His), Biotinylated Dr5,CD262,Death receptor 5,Tnfrsf10b,Killer,MK,Tumor necrosi...	Mouse	HEK293 Cells
	TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 20-40 KDa and the accession number is Q9QZM4.
TMPJ-00418	TRAIL R3/TNFRSF10C Protein, Human, Recombinant (hFc & His) Decoy Receptor 1,Antagonist Decoy Receptor for TRAIL	Human	HEK293 Cells
	Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
TMPK-00248	TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi) DCR2,TNFRSF10D,RSF10D,CD264,TRUNDD,TRAILR4	Human	HEK293 Cells
	TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL-R2/DR5 as well as TRAIL-R3/DcR1 and TRAIL-R4/DcR2 were significantly higher expressed in advanced tumour stages. TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 19.4 kDa and t...
TMPK-00249	TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi), Biotinylated TNFRSF10D,CD264,TRUNDD,DCR2,RSF10D,TRAILR4	Human	HEK293 Cells
	TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL-R2/DR5 as well as TRAIL-R3/DcR1 and TRAIL-R4/DcR2 were significantly higher expressed in advanced tumour stages. TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is ...

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