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Search Results for " tnfr1 "
Targets Recommended: TNF

10

抑制剂 & 化合物

24

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T9921 Infliximab

TNF Apoptosis
Infliximab 是一种与 TNF-α特异性结合的嵌合单克隆 IgG1 抗体，可阻止 TNF-α与 TNFR1和 TNFR2 的相互作用，用于治疗克罗恩病和类风湿性关节炎。
T61111 UCB-5307

TNF Apoptosis
UCB-5307 是一种小分子化合物，可在体外抑制 TNFR1 信号转导和下游功能。 人 TNFα 的 KD 为 9 nM。 TNF 直接通过缓慢的结合动力学结合，KD = 6 nM。 UCB-5307 可以通过预制的 hTNF/hTNFR1 复合物。
T38361 GSK717

IL Receptor; NOD Immunology/Inflammation; NF-κB
GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导，抑制 MDP 刺激的 HEK293/hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。
T68954 UCB-6876

UCB-6876 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins.
T71807 UCB-6786

UCB-6786 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins.
T80561 Atrosab

Atrosab是一种人源化IgG1抗TNFR1抗体，具有拮抗作用。它能够抑制TNF诱导的细胞凋亡(apoptosis)，并减少IL-6和IL-8的生成，有助于研究炎症性疾病。
T27687 JNJ525

JNJ 525,JNJ-525
JNJ525 is an inhibitor of TNFα. JNJ525 inhibits protein function via an aggregation-based mechanism. JNJ525 prevents the formation of TNFα complexes with TNFR1 and TNFR2, the apparent IC50 values for the inhibition of complex formation are 1.2 ± 0.2 μM an
T36097 TNF-α-IN-2

TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in the TNFα trimer upon binding, resulting in disrupted signaling when the trimer interacts with TNFR1. TNF-α-IN-2 holds promise as a valuable tool for investigating the pathogenesis of rheumatoid arthritis[1].
T36486 Benpyrine

Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. Benpyrine (5-20 μM; 14 hours; RAW264.7 cells) pretreatment results in a dose-dependent decrease in the phosphorylation of IκBα in RAW264.7 cells (stimulated with 10 ng/mL TNF-α or 1 μg/mL LPS). Benpyrine abo...
T38263 TBK1/IKKε-IN-4

TBK1/IKKε-IN-4
TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR[1]. TBK1/IKKε-IN-4 (Compound II; 96 hours; A549 andHCC44 cells) treatmentdisplays selective toxicity in TBK1-dependent cancer cell lines (IC50 of ~ 4.2 μM for H441 cells and IC50 of ~0.4 μM for A549 cells)[1].TBK1/IK...

化合物

Infliximab
Cat.No: T9921
Synonym:
Target: TNF
UCB-5307
Cat.No: T61111
Synonym:
Target: TNF
GSK717
Cat.No: T38361
Synonym:
Target: IL Receptor, NOD
UCB-6876
Cat.No: T68954
Synonym:
Target:
UCB-6786
Cat.No: T71807
Synonym:
Target:
Atrosab
Cat.No: T80561
Synonym:
Target:
JNJ525
Cat.No: T27687
Synonym: JNJ 525,JNJ-525
Target:
TNF-α-IN-2
Cat.No: T36097
Synonym:
Target:
Benpyrine
Cat.No: T36486
Synonym:
Target:
TBK1/IKKε-IN-4
Cat.No: T38263
Synonym: TBK1/IKKε-IN-4
Target:
Species：
Human (10)
Mouse (8)
Cynomolgus (2)
Cynomolgus,Rhesus (2)
Rat (2)
Expression System：
HEK293 Cells (20)
E. coli (4)
Tag：
C-His (5)
His (5)
C-hFc (4)
N-6xHis (3)
hFc (3)
Tag Free (2)
His, Avi (1)
His, hFc (1)
Cat. No. Product Name Species Expression System
TMPY-01459 TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His)

p60,TNFR60,TNFAR,TBP1,CD120a,...

 Human HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.7 kDa and the accession number is P19438-1.
TMPY-02535 TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc)

TNFalpha-R1,TNFAR,TNF-R-I,TNF-R,TNFRp55,FP...

 Mouse HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.4 kDa and the accession number is P25118.
TMPY-05475 TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc)

MS5,p55-R,p60,TNFR1-d2,TNFR55,

Human HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48 kDa and the accession number is P19438-1.
TMPK-00564 TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His)

TBP1,TNF-RI,TNFAR,p55,p60,p55-R,TNF-R55,FPF,TNF-R

Cynomolgus HEK293 Cells
Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate the cell death and inflammation associated with TNF-α, while sparing or potentiating the protective effects of TNFR2 signalling.
TMPY-01639 TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His)

TNFalpha-R1,TNFRp55,CD120a,TNF-al...

 Mouse HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.8 kDa and the accession number is P25118.
TMPY-03028 TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (hFc)

tumor necrosis factor receptor superfamily member 1...

 Rat HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.9 kDa and the accession number is P22934.
TMPY-03538 TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (His)

tumor necrosis factor receptor superfamily member 1...

 Rat HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.3 kDa and the accession number is P22934.
TMPJ-00280 TNF R1 Protein, Mouse, Recombinant

Tnfrsf1a,Tumor necrosis factor receptor su...

 Mouse E. coli
Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the...
TMPY-03101 TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His)

tumor necrosis factor receptor superfamily, member 1

Cynomolgus,Rhesus HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is XP_005544817.1&NP_001253134.1.
TMPY-01166 TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His)

TNFR80,p75,TNF-R75,TNFR1B,tumor n...

 Human HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is P20333-1.
TMPY-01697 TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His)

Tnfr-1,TNFR80,TNF-R-II,TNF-αR2,tu...

 Mouse HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is P25119.
TMPY-01696 TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc)

TNF-αR2,TNF-R-II,Tnfr2,TNFalpha-R2,TNFBR,tumor necr...

 Mouse HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.3 kDa and the accession number is P25119.
TMPK-01382 TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His)

p75TNFR,p75TBPII,CD120b,TNF-R75,TNFR

Cynomolgus HEK293 Cells
Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects o...
TMPY-03881 TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (aa 1-268, M196A, His)

TNFR80,p75TNFR,TNF-R-II,CD120b,

Human HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (aa 1-268, M196A, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.7 kDa and the accession number is P20333-2.
TMPY-06600 TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & Avi), Biotinylated

TNFR1B,TNF-R75,TBPII,p75,TNFR80,p...

 Human HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 28.39 kDa and the accession number is NP_001057.1.
TMPY-00934 TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & hFc)

TNF-R75,TBPII,TNF-R-II,TNFR1B,TNFR

Human HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 53 kDa and the accession number is P20333-1.
TMPY-03588 TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (hFc)

tumor necrosis factor receptor superfamily, member 1

Cynomolgus,Rhesus HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.1 kDa and the accession number is XP_005544817.1&NP_001253134.1.
TMPY-05814 TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His), Biotinylated

p75,TBPII,TNF-R-II,CD120b,p75TNFR,TNFBR,TN...

 Human HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession number is P20333-1.
TMPY-02153 TNF beta Protein, Human, Recombinant

LT,TNF β,TNFSF1,肿瘤坏死因子,TNFB,lymphotoxin alpha,lymph...

 Human E. coli
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS...
TMPK-00745 PGLYRP1 Protein, Human, Recombinant (hFc)

PGLYRP1,TAG7,PGLYRP,PGRP-SMGC126894,PGRP,T...

 Human HEK293 Cells
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. PGLYRP1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.2 kDa and the accessio...
TMPK-00749 PGLYRP1 Protein, Mouse, Recombinant (hFc)

PGRPSMGC126896,TNFSF3L,PGLYRP1,TAG7,PGLYRP...

 Mouse HEK293 Cells
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. PGLYRP1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 45.7 kDa and the accessio...
TMPH-01620 TNF beta Protein, Human, Recombinant (His)

Human HEK293 Cells
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
TMPH-02770 TNF beta Protein, Mouse, Recombinant (His)

Mouse E. coli
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. TNF beta Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.8 kDa and the accession number is P09225.
TMPH-02876 RIPK1 Protein, Mouse, Recombinant (His)

Mouse E. coli
Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, i...

重组蛋白

TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His)
Cat.No: TMPY-01459
Species: Human
Expression System: HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-02535
Species: Mouse
Expression System: HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05475
Species: Human
Expression System: HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00564
Species: Cynomolgus
Expression System: HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01639
Species: Mouse
Expression System: HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-03028
Species: Rat
Expression System: HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (His)
Cat.No: TMPY-03538
Species: Rat
Expression System: HEK293 Cells
TNF R1 Protein, Mouse, Recombinant
Cat.No: TMPJ-00280
Species: Mouse
Expression System: E. coli
TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His)
Cat.No: TMPY-03101
Species: Cynomolgus,Rhesus
Expression System: HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His)
Cat.No: TMPY-01166
Species: Human
Expression System: HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01697
Species: Mouse
Expression System: HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-01696
Species: Mouse
Expression System: HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-01382
Species: Cynomolgus
Expression System: HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (aa 1-268, M196A, His)
Cat.No: TMPY-03881
Species: Human
Expression System: HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06600
Species: Human
Expression System: HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & hFc)
Cat.No: TMPY-00934
Species: Human
Expression System: HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (hFc)
Cat.No: TMPY-03588
Species: Cynomolgus,Rhesus
Expression System: HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His), Biotinylated
Cat.No: TMPY-05814
Species: Human
Expression System: HEK293 Cells
TNF beta Protein, Human, Recombinant
Cat.No: TMPY-02153
Species: Human
Expression System: E. coli
PGLYRP1 Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00745
Species: Human
Expression System: HEK293 Cells
PGLYRP1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPK-00749
Species: Mouse
Expression System: HEK293 Cells
TNF beta Protein, Human, Recombinant (His)
Cat.No: TMPH-01620
Species: Human
Expression System: HEK293 Cells
TNF beta Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02770
Species: Mouse
Expression System: E. coli
RIPK1 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02876
Species: Mouse
Expression System: E. coli
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