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Cat. No. | Product Name | ||
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L4100 | TGF-β/Smad靶点化合物库 | 184 compounds | |
184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
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T4283 |
SRI-011381
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TGF-beta/Smad | Stem Cells |
SRI011381 是口服具有活力的 TGF-β信号通路的激活剂,具有神经保护活性。 | |||
T5129 |
SRI-011381 hydrochloride
SRI-011381 hydrochloride [1629138-41-5(free base)] |
TGF-beta/Smad | Stem Cells |
SRI-011381 hydrochloride 是口服具有活力的TGF-β信号通路的激活剂,具有神经保护活性。 | |||
T61389 |
TGFβ1-IN-1
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TGF-beta/Smad | Stem Cells |
TGFβ1-IN-1 是一种具有口服活性的 TGF-β1 抑制剂,抑制 TGF-β1 诱导的纤维化标志物(α-SMA 和纤连蛋白)的产生,可用于研究癌症和自身免疫疾病。 | |||
T24470 |
Mitochonic Acid 35
MA35,MA-35,MA 35,Mitochonic Acid-35 |
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Mitochonic Acid 35 is a dual TNF-α and TGF-β1 inhibitor that acts by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation. | |||
T82951 |
a-TGF (34-43), rat
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a-TGF (34-43), rat 是一种用于免疫研究的活性肽。 | |||
T82409 |
Fepixnebart
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Fepixnebart为人源化IgG4κ抗体,特异性靶向TGF-α(TGFA)。 | |||
T61586 |
TGFβ-IN-2
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TGFβ-IN-2 (Compound 9d) effectively inhibits the accumulation of total collagen induced by TGF-β in NRK-49F cells, with an IC 50 value of 4.31 μM. It also suppresses the in vitro protein expression of COL1A1, α-SMA, and p-Smad3, which are induced by TGF-β. Additionally, TGFβ-IN-2 shows promise as a potential anti-fibrosis compound for in vivo applications through oral administration [1]. | |||
T21978 |
p-nitro-Pifithrin-α
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p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4]. | |||
T83770 |
Klotho-derived Peptide 1 (56-87) (human) TFA
KP1 (56-87) |
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Klotho衍生肽1(KP1)(56-87)是从人类Klotho蛋白质中衍生的肽,具有扰乱TGF-β信号传导的作用。它与TGF-β受体类型1(TGFBR2)和TGF-β受体类型2(TGFBR2;Kds分别为1.41和14.6µM)结合。KP1(10 µg/ml)的预孵育抑制TGF-β在NRK-49F大鼠成纤维细胞中诱导的纤维连接蛋白和α-平滑肌肌动蛋白(α-SMA)水平的增加。在体内,KP1(每天1 mg/kg)选择性地定位于受损的肾脏,并减少血清肌酐和血尿素氮水平,这些是肾功能的标志物,同时也减少了小鼠单侧输尿管阻塞(UUO)和单侧缺血-再灌注损伤诱导的肾脏纤维化模型中的肾纤维化。 | |||
T74996 |
FXR agonist 3
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FXR agonist3 是一种抗 NASH 试剂,通过激活 FXR 起作用。FXR agonist3 抑制 COL1A1、TGF-β1、α-SMA 和 TIMP1的表达,具有抗纤维化活性。FXR agonist3 显著减轻肝脏脂肪变性和炎症,改善肝纤维化水平。 | |||
T71884 |
ß-Carboline-1-carboxylic acid
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β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 µg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells. β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 µg/ml, respectively) but not Hep... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T5S0896 |
Loureirin A
龙血素 A,龙血素A |
Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Loureirin A 是一种黄酮类物质,从龙血树中分离得到,能够降低Akt 的磷酸化,具有抗血小板聚集作用。 |
Cat. No. | Product Name | Species | Expression System |
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TMPY-03958 |
TGF alpha Protein, Human, Recombinant
transforming growth factor α,转化生长因子,transforming gr... |
Human | E. coli |
The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (... | |||
TMPK-00888 |
TGF alpha Protein, Mouse, Recombinant (hFc)
TGF type 1,转化生长因子,TGF-alpha,TGF-<... |
Mouse | HEK293 Cells |
Transforming growth factor-alpha (TGFA) has been proposed as a candidate gene in the etiology of nonsyndromic cleft lip with or without cleft palate (NS-CL/P) and of nonsyndromic cleft palate only (NS-CPO). Biologic support for a role of TGFA arises from its presence at high levels in the epithelial tissue of the medial edge of the palatal shelves at the time of shelf fusion in mice. TGF alpha Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted ... | |||
TMPK-00757 |
TGF alpha Protein, Human, Recombinant (hFc)
TGF type 1,TGFA,TGF-alpha,TGF... |
Human | HEK293 Cells |
Transforming growth factor-alpha (TGFA) has been proposed as a candidate gene in the etiology of nonsyndromic cleft lip with or without cleft palate (NS-CL/P) and of nonsyndromic cleft palate only (NS-CPO). Biologic support for a role of TGFA arises from its presence at high levels in the epithelial tissue of the medial edge of the palatal shelves at the time of shelf fusion in mice. TGF alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted ... | |||
TMPJ-00290 |
GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)
TRNR2,GDNFR-beta,TGF-β-related neurotrophic factor ... |
Human | HEK293 Cells |
GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kina... | |||
TMPJ-00968 |
NAMPT Protein, Human, Recombinant (His)
PBEF,PBEF1,Nicotinamide phosphoribosyltransferase,NAmPRTase,... |
Human | E. coli |
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular enzyme nicotinamide phosphoribosyltranferase (NAMPT) and the adipokine “visfatin”. PBEF is constitutively expressed in the fetal membranes where its greatest expression is in the amnion. It has intracellular and extracellular forms. Most of the intracellular functions of PBEF are ... | |||
TMPJ-00851 |
IDE Protein, Human, Recombinant (His)
Insulysin,Insulinase,Insulin-Degrading Enzyme,IDE,Abeta-Degr... |
Human | HEK293 Cells |
Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted... | |||
TMPJ-00680 |
ANGPTL7 Protein, Human, Recombinant (His)
CDT6,Cornea-derived transcript 6 protein,Angiopoietin-like p... |
Human | HEK293 Cells |
Angiopoietin-like 7 (ANGPTL7) is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL7 shares 89% aa sequence identity with mouse and rat ANGPTL7. It is secreted as a 45-50kDa monomer that forms disulfide-linked homotrimers and tetramers via the coiled coil domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated ... | |||
TMPY-01027 |
Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)
carnitine palmitoyltransferase 1B (muscle),AV080368,Mcp-1 |
Mouse | HEK293 Cells |
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared w... |