Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T125567 |
AAL Toxin TC1
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AAL Toxin TC1 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125567。 | |||
T23423 | TC 1 | Others | Others |
σ1 receptor ligand | |||
T9083 |
TC11
CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 |
BCL; Caspase; CDK | Apoptosis; Cell Cycle/Checkpoint; Proteases/Proteasome |
TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) 是一种有效的肿瘤细胞增殖抑制剂,并通过激活 caspase-3、8 和 9 诱导细胞凋亡。在长时间有丝分裂阻滞期间,它诱导 MCL1降解导致凋亡。它作为苯酞酰亚胺衍生物在结构上与免疫调节药物相关。 | |||
TP2112L |
TC14012 acetate
TC14012 acetate(368874-34-4 free base) |
CXCR; Arrestin | Autophagy; GPCR/G Protein; Immunology/Inflammation |
TC14012 acetate 是 T140 的血清稳定衍生物,是一种选择性的肽模拟 CXCR4 拮抗剂,IC50 为 19.3 nM。 TC14012 还是一种有效的 CXCR7 激动剂,EC50 为 350 nM,可将 β-arrestin 2 募集到 CXCR7。 TC14012 具有抗癌活性和抗 HIV 活性。 | |||
T61531 |
NFATc1-IN-1
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RANKL/RANK | NF-κB |
NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuclear translocation of NFATc1. Due to its remarkable properties, NFATc1-IN-1 holds significant potential for advancing research related to osteoclastic diseases [1]. | |||
T34425 |
RTC13
Read-through compound 13,RTC 13,RTC-13 |
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RTC13, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy. | |||
T74400 | TC113 | ||
TC113是一种与c(RGDyK)偶联的Gemcitabine。它通过整合素αvβ3可被A549细胞内化。此外,TC113对WM266.4和A549细胞表现出显著的抗增殖效果。 | |||
TP2112 |
TC14012
TC 14012 |
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CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7). | |||
T75801 |
TC14012 TFA
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TC14012 TFA 是 T140 的血清稳定衍生物,是一种选择性的 CXCR4拮抗剂,IC50为 19.3 nM。TC14012 TFA 是有效的 CXCR7激动剂,可将 β-arrestin2 募集到 CXCR7,EC50为 350 nM。TC14012 TFA 具有抗 HIV 活性和抗癌活性。 | |||
T34426 |
RTC14
Read-through compound-14,RTC 14,RTC-14,Read-through compound 14 |
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RTC14, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy. | |||
T17010 |
TC13172
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Others | Others |
TC13172 is an inhibitor of mixed lineage kinase domain-like protein (EC50: 2 nM for HT-29 cells). |