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Cat. No. | Product Name | Target | Signaling Pathways |
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T7943 |
Fluphenazine decanoate
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂,是一种长效吩噻嗪抗精神病药,用于精神分裂症的研究。 | |||
T72081 |
CpCDPK1/TgCDPK1-IN-2
|
Parasite | Microbiology/Virology |
CpCDPK1/TgCDPK1-IN-2 是 CpCDPK1 和 TgCDPK1 双重抑制剂,对 CpCDPK1 和 TgCDPK1 有抑制这样,IC50 值分别为 12 和 5 nM。CpCDPK1/TgCDPK1-IN-2 可用于研究弓形虫 (T. gondii)、细小隐孢子虫 (C. parvum) 和隐孢子虫 (C. hominus) 等顶复门原生动物感染相关疾病。 | |||
T36692 |
Fanotaprim
|
DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Fanotaprim 是二氢叶酸还原酶的有效抑制剂,抑制 tgDHFR (Toxoplasma gondiiDHFR) 和 hDHFR (human DHFR)的 IC50分别为 1.57 和 308 nM。Fanotaprim 在研究弓形虫病方面具有价值。 | |||
T21687 |
Conoidin A
|
Parasite | Microbiology/Virology |
Conoidin A 是刚地弓形虫过氧化物酶 II 的细胞通透性抑制剂,有杀线虫特性。它共价结合 TgPrxII 的过氧化物催化位点 Cys47,不可逆地抑制其过氧化物活性,IC50为 23 µM。它也抑制哺乳动物 PrxI 和 PrxII 的氧化。它具有抗氧化、神经保护作用,可研究缺血性心脏病。 | |||
T61671 |
MMV687807
|
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MMV687807 is a potent anthelmintic compound exhibiting strong efficacy against Toxoplasma gondii (T. gondii). It demonstrates an IC50 value of 0.15 μM and a CC50 value of 1.69 μM [1]. | |||
T11846 | LHVS | Cysteine Protease | Proteases/Proteasome |
LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine protease inhibitor. | |||
T40191 |
17-GMB-APA-GA
|
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17-GMB-APA-GA, a potent HSP90 inhibitor, is an ADC cytotoxin commonly employed for studying latent T. gondii infection. | |||
T61114 | Anti-Trypanosoma cruzi agent-2 | ||
Anti-Trypanosoma cruzi agent-1 (Compd 3b) 对NINOA trypomastigote (IC50= 0.51 μM) 和 INC-5 epimastigote (IC50= 3.06 μM) 锥虫具有选择性,具有有效的抗弓形虫活性。 | |||
T17257 |
WR99210
|
DHFR; Antifolate; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
WR99210 是一种有效的、可口服的且毒性较低的二氢叶酸还原酶 (DHFR) 抑制剂 (IC50<0.075 nM)。WR99210 具有较好的抗寄生虫活性,对间日疟原虫和恶性疟原虫株 (包括耐 Pyrimethamine 的恶性疟原虫株) 以及弓形虫有良好的抑制作用。 | |||
T83881 |
4-(3,4-Difluorobenzo)curcumin
CDF |
||
4-(3,4-Difluorobenzo)curcumin(CDF)是一种具有抗寄生虫和抗癌活性的半合成香豆素。它能减少被T. gondii持鞭毛体和无鞭毛体感染的Vero细胞的数量(EC50s分别为0.8和0.37 µM)。CDF(4和8 µM)通过增强5-氟尿嘧啶和奥沙利铂对化药抵抗性HCT116细胞主要和次要结肠球形成的抑制作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35750 |
Trypacidin
|
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Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1 1.Balan, J., Ebringer, L., Nemec, P., et al.Ant... |