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14

抑制剂 & 化合物

2

天然产物

15

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T25415	Fenpropimorph Forbel 750,Ro 14-3169/000,Mistral T,Fenpropimorphe
	Fenpropimorph is used as a small molecule fungicide.
T25621	Lankacidinol A Lankacidinol 14-acetate,Antibiotic T-2636D,P 2636 D,P2636 D,P-2636 D
	Lankacidinol A is a metabolite of macrolide antibiotic.
T22553	Adaphostin 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Adaphostin (NSC-680410) 是 AG957 金刚烷酯，是一种 p210bcr/abl 抑制剂，可诱导 T 淋巴细胞白血病细胞系凋亡。它增加了 CLL B 细胞内活性氧的水平，对慢性和急性髓系白血病细胞具有显著的选择性活性。
T37549	Bacillosporin C
	Bacillosporin C is an oxaphenalenone dimer originally isolated from T. bacillosporus. Bacillosporin C, an anhydride, is formed from the lactone bacillosporin D in the mangrove endophytic fungus SBE-14. Similar oxaphenalenone dimers have antibiotic activity and inhibit acetylcholinesterase.
T79254	Antitrypanosomal agent 14	Parasite	Microbiology/Virology
	Antitrypanosomal agent 14（Compound 1）是一种针对T. brucei的有效抑制剂，其EC50为0.47 μM。它对TbGSK3的抑制作用表现在IC50为12 μM。该化合物主要用于非洲人类锥虫病的研究。
T72668	PD-1/PD-L1-IN-26	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-26 (Compound II-14) 是一种高效的 PD-1/PD-L1 抑制剂，IC50 为 0.0380 μM。该化合物能够激活肿瘤免疫微环境，通过促进 CD4+ T 细胞向肿瘤组织的浸润。PD-1/PD-L1-IN-26 展示了在癌症治疗研究中的应用潜力。
T36982	CXCR3 Antagonist 6c
	CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3).1It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC50= 0.06 μM). It is selective for CXCR3 over a panel of 14 human G protein-coupled receptors at 10 μM. CXCR3 antagonist 6c inhibits CXCR3-mediated migration of isolated human T cells (IC50= ~100 nM). 1.Cole, A.G., Stroke, I.L., Brescia, M.-R., et al.Identification and initial eva...
T83779	EP4 Antagonist 14 Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
	EP4 antagonist 14是一种前列腺素E2（PGE2）受体亚型EP4的拮抗剂，其在使用表达人源受体的HEK293细胞的报告基因测定中的IC50值为1.1 nM。它还能抑制PGE2诱导的同种细胞中的β-阿雷斯汀招募（IC50 = 0.9 nM）。EP4 antagonist 14（10 µM）能减少RAW 264.7巨噬细胞中PGE2诱导的mRNA表达，这些mRNA编码Il-4、巨噬细胞甘露糖受体1（Mrc1）、几丁质酶样蛋白3（Chil3）、趋化因子（C-X-C）基序配体1（Cxcl1）、表达在髓样细胞上的触发受体2（Trem2）和精氨酸酶-1（Arg1）。在体内，EP4 antagonist 14（每天30 mg/kg），结合抗PD-1抗体，能够在CT26小鼠结肠癌模型中抑制肿瘤生长并增加CD8+ T细胞对肿瘤的浸润。
T36412	Multiflorenol
	Multiflorenol is a triterpene that has been found in T. kirilowii seeds.1 It inhibits in vitro activation of Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter phorbol 12-myristate 13-acetate in a concentration-dependent manner. \|1. Akihisa, T., Tokuda, H., Ichiishi, E., et al. Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines. Cancer Lett. 173(1), 9-14 (2001).
T35904	O-11
	O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface gl...
T36539	Nocardamine
	Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4 1.Lo...
T36152	14S(15R)-EET
	14S(15R)-EET is an oxylipin and a cytochrome P450 metabolite of arachidonic acid .114S(15R)-EET binds to isolated guinea pig monocytes with a Kivalue of 612.5 nM in a competitive binding assay using [3H]14(15)-EET.2It induces dilation of precontracted isolated canine epicardial arterioles (EC50= 4 pM) and denuded porcine subepicardial arterioles (EC50= 3 pM).3Unlike 14R(15S)-EET, 14S(15R)-EET does not inhibit COX in enzyme assays or isolated platelets.4 1.Daikh, B.E., Lasker, J.M., Raucy, J.L., ...
T37791	A-971432
	A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 &#181M, respectively). It inhibits forskolin-induced cAMP production in CHO cells expressing S1P5 (EC50 = 4.1 nM). A-971432 (1 &#181M) increases electrical resistance of hCMEC/D3 cells in an in vitro blood-brain barrier model, indicating enhanced barrier integrity, and attenuates blood-brain barrier leakage in an R6/2 transgenic mouse model of Huntington’s ...
T36947	Pyrithiamine (hydrobromide)
	Pyrithiamine is the pyridine analog of thiamine that prevents growth of organisms that require intact thiamine. [1] It inhibits the growth of bacterial and fungal species at a pyrithiamine:thiamine ratio of 10:1 in growth media and induces symptoms of thiamine deficiency in mice at a dietary ratio of 3:1. These effects are reversible with addition of sufficient thiamine in all species. Pyrithiamine inhibits the formation of cocarboxylase from thiamine in chicken blood in a dose-dependent manner....

化合物

Cat.No: T25415

Synonym: Forbel 750,Ro 14-3169/000,Mistral T,Fenpropimorphe

Cat.No: T25621

Synonym: Lankacidinol 14-acetate,Antibiotic T-2636D,P 2636 D,P2636 D,P-2636 D

Cat.No: T22553

Synonym: 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410

Target: Bcr-Abl

Bacillosporin C

Cat.No: T37549

Antitrypanosomal agent 14

Cat.No: T79254

Target: Parasite

PD-1/PD-L1-IN-26

Cat.No: T72668

Target: PD-1/PD-L1

CXCR3 Antagonist 6c

Cat.No: T36982

EP4 Antagonist 14

Cat.No: T83779

Synonym: Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14

Cat.No: T36412

Cat.No: T35904

Cat.No: T36539

Cat.No: T36152

Cat.No: T37791

Pyrithiamine (hydrobromide)

Cat.No: T36947

Cat. No.	Product Name	Target	Signaling Pathways
T6S1885	Benzoylmesaconine Mesaconine 14-benzoate,苯甲酰新乌头原碱	Others	Others
	Benzoylmesaconine (Mesaconine 14-benzoate) 是乌头汤最丰富的组分。其中乌头汤可用于研究类风湿性关节炎。
TN5307	Otophylloside T
	Otophylloside T 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5307，CAS号为 1642306-14-6。

天然产物

Benzoylmesaconine

Cat.No: T6S1885

Synonym: Mesaconine 14-benzoate,苯甲酰新乌头原碱

Target: Others

Otophylloside T

Cat.No: TN5307

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04951	CD27/TNFRSF7 Protein, Human, Recombinant (His), Biotinylated S152.LPFS2,T14,S152. LPFS2,TNFRSF...	Human	Baculovirus Insect Cells
	CD27/TNFRSF7 Protein, Human, Recombinant (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.77 kDa and the accession number is P26842.
TMPY-03401	CD27/TNFRSF7 Protein, Human, Recombinant (His) S152. LPFS2,CD27 molecule,S152.LPFS2,TNFRSF7,S152,<...	Human	Baculovirus Insect Cells
	CD27/TNFRSF7 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.77 kDa and the accession number is P26842.
TMPK-00152	CD27/TNFRSF7 Protein, Cynomolgus, Recombinant (His) CD27 antigen,S152. LPFS2,S152,TNFRSF7,...	Cynomolgus	HEK293 Cells
	CD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a co‑stimulatory molecule that supports lymphocyte activation and survival. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis.
TMPJ-00616	CD27/TNFRSF7 Protein, Rhesus macaque, Recombinant (His) TNFRSF7,T-Cell Activatio...	Rhesus	HEK293 Cells
	CD27/TNFRSF7 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 40 KDa and the accession number is F7BYS2.
TMPJ-00615	CD27/TNFRSF7 Protein, Rhesus macaque, Recombinant (hFc) CD27,T14,T-Cell Activa	Rhesus	HEK293 Cells
	CD27/TNFRSF7 Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-90 KDa and the accession number is F7BYS2.
TMPY-05415	CD27/TNFRSF7 Protein, Human, Recombinant (hFc & Avi), Biotinylated S152,CD27 molecule,TNFRSF7,S152.LPFS2,T	Human	HEK293 Cells
	CD27/TNFRSF7 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 47.8 kDa and the accession number is P26842.
TMPY-03070	CD27/TNFRSF7 Protein, Human, Recombinant (rFc) T14,S152. LPFS2,S152,Tp55,T	Human	HEK293 Cells
	CD27/TNFRSF7 Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 44.4 kDa and the accession number is P26842.
TMPY-05445	CD27/TNFRSF7 Protein, Human, Recombinant (hFc) CD27 molecule,T14,S152.LPFS2,Tp55...	Human	HEK293 Cells
	CD27/TNFRSF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.1 kDa and the accession number is P26842.
TMPJ-00444	Siglec-2/CD22 Protein, Mouse, Recombinant (aa 22-702, His) CD22 antigenMGC130020,B-cell receptor CD22...	Mouse	HEK293 Cells
	Siglec-2/CD22 Protein, Mouse, Recombinant (aa 22-702, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-120 KDa and the accession number is AAA02562.1.
TMPJ-00392	Siglec-2/CD22 Protein, Human, Recombinant (His & Avi), Biotinylated T-cell surface antigen Leu-14,CD2...	Human	HEK293 Cells
	Siglec-2/CD22 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 110-130 KDa and the accession number is P20273.
TMPJ-00393	Siglec-2/CD22 Protein, Human, Recombinant (hFc) BL-CAM,SIGLEC2FLJ22814,CD22 antigenMGC1300...	Human	HEK293 Cells
	Siglec-2/CD22 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-150 KDa and the accession number is P20273.
TMPK-00130	LIGHT/TNFSF14 Trimer Protein, Human, Recombinant (His & Flag) TNFSF14, TR2,CD258,LTg,L...	Human	HEK293 Cells
	LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein of the TNF superfamily. It is recognized by herpesvirus entry mediator (HVEM), as well as decoy receptor 3.This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells.
TMPJ-00168	HVEM Protein, Mouse, Recombinant (hFc) Tnfrsf14,Herpesvirus entry media<...	Mouse	HEK293 Cells
	Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in ...
TMPJ-00129	BTLA Protein, Human, Recombinant (His) B- and T-Lymphocyte-Associated Pr...	Human	HEK293 Cells
	B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a ...
TMPJ-01316	IL-21 Protein, Mouse, Recombinant (His) 白细胞介素,IL-21,Interleukin-21,白介素,IL21	Mouse	E. coli
	Interleukin-21(IL-21) is an approximately 14 kDa cytokine which belongs to the IL-15/IL-21 family. Mature mouse IL-21 shares 66%,59%, 58%, and 88% aa sequence identity with mature canine, human, rabbit, and rat IL-21, respectively. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex (IL-21 specific IL-21 R). IL-21 is a cytokine that has potent regulatory effects on cells of the immun...

重组蛋白

CD27/TNFRSF7 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-04951

Species: Human

Expression System: Baculovirus Insect Cells

CD27/TNFRSF7 Protein, Human, Recombinant (His)

Cat.No: TMPY-03401

Species: Human

Expression System: Baculovirus Insect Cells

CD27/TNFRSF7 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00152

Species: Cynomolgus

Expression System: HEK293 Cells

CD27/TNFRSF7 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPJ-00616

Species: Rhesus

Expression System: HEK293 Cells

CD27/TNFRSF7 Protein, Rhesus macaque, Recombinant (hFc)

Cat.No: TMPJ-00615

Species: Rhesus

Expression System: HEK293 Cells

CD27/TNFRSF7 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-05415

Species: Human

Expression System: HEK293 Cells

CD27/TNFRSF7 Protein, Human, Recombinant (rFc)

Cat.No: TMPY-03070

Species: Human

Expression System: HEK293 Cells

CD27/TNFRSF7 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05445

Species: Human

Expression System: HEK293 Cells

Siglec-2/CD22 Protein, Mouse, Recombinant (aa 22-702, His)

Cat.No: TMPJ-00444

Species: Mouse

Expression System: HEK293 Cells

Siglec-2/CD22 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00392

Species: Human

Expression System: HEK293 Cells

Siglec-2/CD22 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00393

Species: Human

Expression System: HEK293 Cells

LIGHT/TNFSF14 Trimer Protein, Human, Recombinant (His & Flag)

Cat.No: TMPK-00130

Species: Human

Expression System: HEK293 Cells

HVEM Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00168

Species: Mouse

Expression System: HEK293 Cells

BTLA Protein, Human, Recombinant (His)

Cat.No: TMPJ-00129

Species: Human

Expression System: HEK293 Cells

IL-21 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01316

Species: Mouse

Expression System: E. coli

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