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19

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T75349	CDP-Star
	CDP-Star 是碱性磷酸酶的化学发光底物。CDP-Star 可用于酶联免疫分析。
T2250	DY131 DY 131,GSK 9089,DY-131	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Smo	Endocrinology/Hormones; Stem Cells
	DY131 (DY-131) 是选择性的 ERRγ 和 ERRβ 激动剂，对 ERRα，ERα 和 ERβ 无效。它对Smo 的信号传导具有抑制作用。
T38410	Phosphoramide mustard	DNA Alkylation; Drug Metabolite	DNA Damage/DNA Repair; Metabolism
	Phosphoramide mustard 是环磷酰胺的毒性代谢物物，具有抗癌活性且对卵巢具有毒性，可诱导 DNA 损伤。
T2408	Ostarine MK-2866,GTX-024,Enobosarm	Androgen Receptor	Endocrinology/Hormones
	Ostarine (MK-2866) 是一种具有合成代谢活性的非甾体药物。选择性雄激素受体调节剂 (SARM) GTx-024 旨在像睾酮一样发挥作用，从而促进和/或维持性欲、生育能力、前列腺生长以及肌肉生长和力量。模仿睾酮的作用，这种药物可以增加瘦体重，从而改善癌症恶病质高代谢状态下的肌肉萎缩。
T19736	Aniline mustard Mesylerythrol,NSC-18429,N,N-双(2-氯乙基)苯胺,Lymphocin	Others	Others
	Aniline mustard (Mesylerythrol) 是具有抗肿瘤活性的烷基化芥末。
T15600	Istaroxime PST2744	Others	Others
	Istaroxime is an effective inhibitor of Na+, K+-ATPase (IC50: 0.11 μM).
T69179	Imidazole mustard
	Imidazole mustard is an inhibitor of purine nucleoside synthesis.
T36701	Phosphoramide mustard (cyclohexanamine)
	Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce...
T76850	Dostarlimab
	Dostarlimab (TSR-042) 是一种人源化抗PD-1单克隆抗体。Dostarlimab 与人PD-1具有高亲和力，并竞争性地抑制其与其配体PD-L1和 PD-L2 的相互作用，IC50s 分别为 1.8 nM 和 1.5 nM。
T126123	Wistariasaponin B2
	Wistariasaponin B2 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126123，CAS号为 126594-46-5。
T25504	Histargin
	Histargin is an enzyme inhibitor separated from Streptomyces roseoviridis.
T69975	Istaroxime oxalate
	Istaroxime, also known as PST-2744, is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Na+/K+ ATPase inhibition increases intracellular sodium levels, which reverses the driving force of the sodium/calcium exchanger, inhibiting calcium extrusion and possibly facilitating calcium entry. Additionally, Istaroxime increases intracellular calcium by improving the efficacy by which intracellular calcium triggers sarco...
T37031	Quinacrine mustard hydrochloride Quinacrine mustard HCl	Autophagy	Autophagy
	Quinacrine mustard hydrochloride 是一种荧光染料,也是一种多环芳香剂，可作为诱变剂诱导细菌的突变体。Quinacrine mustard hydrochloride 能选择性地与腺嘌呤-胸腺嘧啶（AT）碱基对结合，而不是与鸟嘌呤-胞嘧啶（GC）碱基对结合，诱导细胞周期停滞在 G2/M 期。Quinacrine mustard (hydrochloride) 已被用于标记移相染色体，以通过自动放射摄影技术进行核型分析。
T126124	Wistariasaponin A
	Wistariasaponin A 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126124，CAS号为 126594-36-3。
T23753	Arctigenin mustard AgM
	Arctigenin mustard is a tumor-growth inhibiting substance.
T15599	Istaroxime hydrochloride PST2744 hydrochloride	Others	Others
	Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
T29600	Acetylethylcholine mustard Aech-M
	Acetylethylcholine mustard can effect muscarinic receptor-coupled attenuation of cAMP formation for intact GH3 cells.
T74284	SH379
	SH379为2-甲基嘧啶-稠合三环二萜衍生物，是具有口服活性的有效抗迟发性性腺机能减退剂。它显著促进StAR与3β-HSD等关键睾酮合成相关酶的表达，并通过调节AMPK/mTOR信号通路刺激自噬。
T72213	Efonidipine hydrochloride NZ-105 hydrochloride
	Efonidipine(NZ-105)盐酸盐是T 型和L 型钙离子通道双重阻断剂。

化合物

Cat.No: T75349

Cat.No: T2250

Synonym: DY 131,GSK 9089,DY-131

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Smo

Phosphoramide mustard

Cat.No: T38410

Target: DNA Alkylation, Drug Metabolite

Cat.No: T2408

Synonym: MK-2866,GTX-024,Enobosarm

Target: Androgen Receptor

Aniline mustard

Cat.No: T19736

Synonym: Mesylerythrol,NSC-18429,N,N-双(2-氯乙基)苯胺,Lymphocin

Target: Others

Cat.No: T15600

Synonym: PST2744

Target: Others

Imidazole mustard

Cat.No: T69179

Phosphoramide mustard (cyclohexanamine)

Cat.No: T36701

Cat.No: T76850

Wistariasaponin B2

Cat.No: T126123

Cat.No: T25504

Istaroxime oxalate

Cat.No: T69975

Quinacrine mustard hydrochloride

Cat.No: T37031

Synonym: Quinacrine mustard HCl

Target: Autophagy

Wistariasaponin A

Cat.No: T126124

Arctigenin mustard

Cat.No: T23753

Synonym: AgM

Istaroxime hydrochloride

Cat.No: T15599

Synonym: PST2744 hydrochloride

Target: Others

Acetylethylcholine mustard

Cat.No: T29600

Synonym: Aech-M

Cat.No: T74284

Efonidipine hydrochloride

Cat.No: T72213

Synonym: NZ-105 hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
TN6986	Corn starch
	Corn starch is a natural product.
T83419	1α-Hydroxy-3-deoxypseudoanisatin
	1α-Hydroxy-3-deoxypseudoanisatin (Iso-γ-fagarine) 是倍半萜类化合物，可从八角(Illicium merrillianum)果皮中分离。
T79975	Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside	HBV	Microbiology/Virology
	Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside（化合物1）是一种具有抗HBV活性的木脂素类化合物。该化合物对HBV表面抗原（HBsAg）的IC50为0.58 mM，而对HBV e抗原（HBeAg）的IC50 > 2.4 mM。其可从八角茴香中提取分离。

天然产物

Cat.No: TN6986

1α-Hydroxy-3-deoxypseudoanisatin

Cat.No: T83419

Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside

Cat.No: T79975

Target: HBV

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