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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T10324	Anhydrosimvastatin Dehydro simvastatin,脱水辛伐他汀	HMG-CoA Reductase	Metabolism
	Anhydrosimvastatin (Dehydro simvastatin) 是 Simvastatin 的一种杂质。其中Simvastatin 是竞争性的 HMG-CoA 还原酶抑制剂。
T24865	Tenivastatin L-654969,L654969,Simvastatin acid,L 654969,Simvastatin hydroxy acid	ROS; HMG-CoA Reductase	Immunology/Inflammation; Metabolism
	Tenivastatin (Simvastatin acid) 是一种抗高脂血症的 HMG-CoA 还原酶抑制剂，抑制活性氧 (ROS) 产生，可用于研究原发性高脂血症。
T40557	Simvastatin Acyl-β-D-glucuronide
	Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM.
T10070	2'-Ethyl Simvastatin	HMG-CoA Reductase	Metabolism
	2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition.
T72155	(Rac)-3′-Hydroxy simvastatin
	(Rac)-3′-Hydroxy simvastatin 是一种 Simvastatin 代谢物。Simvastatin 是一种竞争性的 HMG-CoA 还原酶抑制剂，Ki 值为 0.2 nM。
T64292	Simvastatin acid calcium hydrate
	Simvastatin acid (Tenivastatin) calcium hydrate 是一种具有口服具有活力的 HMG-CoA 还原酶 (HMGCR) 抑制剂。Simvastatin acid calcium hydrate 能够调节心肌细胞和转染 OATP3A1 基因的 HEK293 细胞的 OATP3A1 表达。Simvastatin acid calcium hydrate 也能够抑制吲哚酚硫酸盐 (indoxyl sulfate) 介导的活性氧 (ROS) 产生。
T10136	4-Acetylsimvastatin	Others	Others
	4-Acetylsimvastatin is acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki: 0.2 nM).
T20937	Dodecenylsuccinic anhydride 2-十二烯基-丁二酸酐,Rikacid DDSA,Dodecenylsuccinic acid anhydride,DDSA	Others	Others
	Dodecenylsuccinic anhydride (DDSA) 可与胶原水凝胶接枝，作为疏水性伤口敷料掺入辛伐他汀后，在治疗溃疡和预防伤口感染方面具有潜在应用。

化合物

Anhydrosimvastatin

Cat.No: T10324

Synonym: Dehydro simvastatin,脱水辛伐他汀

Target: HMG-CoA Reductase

Tenivastatin

Cat.No: T24865

Synonym: L-654969,L654969,Simvastatin acid,L 654969,Simvastatin hydroxy acid

Target: ROS, HMG-CoA Reductase

Simvastatin Acyl-β-D-glucuronide

Cat.No: T40557

Synonym:

Target:

2'-Ethyl Simvastatin

Cat.No: T10070

Synonym:

Target: HMG-CoA Reductase

(Rac)-3′-Hydroxy simvastatin

Cat.No: T72155

Synonym:

Target:

Simvastatin acid calcium hydrate

Dodecenylsuccinic anhydride

Cat.No: T20937

Synonym: 2-十二烯基-丁二酸酐,Rikacid DDSA,Dodecenylsuccinic acid anhydride,DDSA

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T0687	Simvastatin 辛伐他汀,MK-0733,MK 733	Apoptosis; Mitophagy; Ferroptosis; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Simvastatin (MK 733) 是一种 HMG-CoA 还原酶抑制剂 (Ki=0.2 nM)，具有口服活性。Simvastatin 具有降血脂活性，可以抑制肝脏产生胆固醇，还可以用于预防心血管疾病。
T16885	Simvastatin acid ammonium 辛伐他汀铵盐,Tenivastatin ammonium	Others	Others
	Simvastatin ammonium is an active metabolite of simvastatin lactone mediated. Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 ge