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20

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22465	1,2-Distearoyl-sn-glycerol	Others	Others
	1,2-Distearoyl-sn-glycerol 是一种内标物，可用于分离和鉴定 1,2-diacyl-sn-glycerol (DAG) 的分子种类。
T29059	UMK57 UMK 57,UMK-57	Kinesin	Cytoskeletal Signaling
	UMK57 是一种CENP-Ei、MCAK 增强剂，选择性促进 k-MT 附着错误纠正以抑制染色体错误分离的小分子化合物，可以通过破坏有丝分裂过程中动粒微管 (k-MT) 附着的稳定性来提高染色体分离保守性。
T1055	Ifosfamide NSC109724,Isophosphamide,异环磷酰胺	DNA Alkylator/Crosslinker; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Ifosfamide (NSC-109724) 是一种烷化剂，具有抗肿瘤活性。它烷基化并形成 DNA 交联，从而防止 DNA 链分离和 DNA 复制。它是一种前药，必须通过肝微粒体酶的羟基化来激活。
T16335	Nonaethylene glycol monododecyl ether Nonaoxyethylene monododecyl ether,Polidocanol,聚醚醇	Others	Others
	Nonaethylene glycol monododecyl ether (Polidocanol) 是一种非离子表面活性剂和聚乙二醇清洁剂，可用于蛋白质分离和纯化，以及用于形成初始聚结的 O/W 乳剂液滴。
T41039	Gel filtration medium G-100
	Gel filtration medium G-100, a substance designed for protein purification, enables the separation and purification of proteins through gel filtration.
T36816	S-trityl-L-Cysteine STLC	Kinesin	Cytoskeletal Signaling
	S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM，抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。
TD0078	Succinimidyl 7-methoxycoumarin-3-carboxylate 7-甲氧基-3-羧基香豆素琥珀酰亚胺酯,7-Methoxycoumarin-3-carboxylic acid, succinimidyl ester
	7-Methoxycoumarin-3-carboxylic acid may be used as a reference compound in the purification, separation and analysis of coumarin compounds.
T40311	Sucrose-epichlorohydrin copolymer Sucrose-epichlorohydrin copolymer,Polysucrose 400
	Sucrose-epichlorohydrin copolymer primarily serves as a macromolecular crowder facilitating protein liquid-liquid phase separation (LLPS).
T24528	Netzahualcoyonol
	Netzahualcoyonol has antibacterial and cytotoxic activity. Bioactivity-directed separation led to the isolation of tingenone and Netzahualcoyonol as biologically active materials.
T37812	6-O-Sulfo-β-cyclodextrin (sodium salt)
	6-O-Sulfo-β-cyclodextrin is a sulfated cyclodextrin.1It has been used for the chiral separation of nadolol racemates by capillary electrophoresis. 1.Wang, F., Dowling, T., Bicker, G., et al.Electrophoretic chiral separation of pharmaceutical compounds with multiple stereogenic centers in charged cyclodextrin mediaJ. Sep. Sci.24(5)378-384(2001)
T20229	L-Erythrose L-(+)-Erythrose
	L(+)-Erythrose is an aldotetrose rare sugar. It may be used in glycation studies and as a reference compound in tetrose carbohydrate separation and quantitation analysis. It also can be used to help identify and characterize erythrose reductase(s) and to
T77844	Mal-PEG2-Val-Cit-PABA
	Mal-PEG2-Val-Cit-PABA 是一种ADC linker，具有可降解性，用于抗体偶联活性分子（ADC）的合成。
T68428	ZK-Thiazolidinone
	ZK-Thiazolidinone, also known as TAL, is an ATP-competitive inhibitor of PLK1. In vitro, ZK-Thiazolidinone counteracts the role of Plk1 in previously established functions, notably, sister chromatid separation, centrosome maturation, and bipolar spindle assembly. In vivo, ZK-Thiazolidinone selectively inhibits PLK1 and causes a prometaphase-like mitotic (G2–M) arrest. ZK-Thiazolidinone inhibits human PLK1 (IC50, 19± 12 nM) and various human and mouse tumor cell lines (IC50, 0.2–1.3 μM). ZK-Thiaz...
T62623	G247
	G247是一种特异的 MsbA 抑制剂。G247 作为跨膜结构域 (TMDs) 楔形物，对称地增加核苷酸结合结构域 (NBDs) 的分离，并防止 MsbA 的构象转变。G247 利用增加 NBDs 间的距离来抑制 ATP 酶活性。
T80761	XQ2B
	XQ2B为cGAS抑制剂，针对蛋白质-DNA相互作用及其相分离。该化合物可阻止单纯疱疹病毒1（HSV-1）触发的抗病毒免疫响应，在体外与体内都能增强HSV-1的感染效果。
T82546	DiSBAC10
	DiSBAC10是一种电压敏感荧光探针，用于FRET检测中研究细胞膜的电活动。在静息极化的细胞中，DiSBAC10位于膜的外leaflet，从激发的荧光素标记蛋白那里接收光子，并以更高的波长重新发射光子。当细胞去极化时，DiSBAC10迅速转移到膜的内leaflet，从而增加了荧光团之间的距离并减少FRET信号。
T35414	α-Cyclodextrin (hydrate)
	α-Cyclodextrin (α-CD) is a saccharide comprised of six glucose subunits linked by α-1,4 bonds, which results in a cone-shaped molecule.1It contains a hydrophobic interior and hydrophilic exterior, which allow it to form inclusion complexes with wide variety of molecules, conferring enhanced solubility and stabilization to the molecules. α-CD has commonly been used in the separation and purification of chemicals on an industrial scale.1,2Formulations containing α-CD have been used in the pharmace...
T40240	Poly-L-lysine hydrochloride	Antibacterial	Microbiology/Virology
	Poly-L-lysine hydrochloride 作为一种非特异性附着因子，通过增强细胞膜上存在的负电离子与培养基质表面之间的静电相互作用，在促进细胞对固体基质的附着方面起着关键作用。Poly-L-lysine hydrochloride 是一种多肽，在低浓度时表现出促进液-液相分离（LLPS）的能力，而在高浓度时抑制 LLPS。由于其阳离子肽的性质，Poly-L-lysine hydrochloride 抗菌活性。这些特性使它成为增强细胞粘附力、调节相分离动力学和展示抗菌活性的重要成分。
T83886	icFSP1 TFA
	icFSP1是一种抑制剂，针对的是铁死亡抑制蛋白1（FSP1）。在2.5 µM的浓度下使用时，能够引发FSP1在细胞中的凝聚和相分离，但在无细胞测试中并不抑制FSP1的酶活性（IC50 = > 30 µM）。icFSP1以浓度依赖的方式诱导HT-1080纤维肉瘤细胞的铁死亡。在体内，icFSP1（50 mg/kg）通过使用人类过表达FSP1，Gpx4-/-Fsp1-/-的B16/F10细胞，在B16/F10鼠黑色素瘤模型中减少肿瘤体积和重量。
T36701	Phosphoramide mustard (cyclohexanamine)
	Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce...

化合物

1,2-Distearoyl-sn-glycerol

Cat.No: T22465

Target: Others

Cat.No: T29059

Synonym: UMK 57,UMK-57

Target: Kinesin

Cat.No: T1055

Synonym: NSC109724,Isophosphamide,异环磷酰胺

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis

Nonaethylene glycol monododecyl ether

Cat.No: T16335

Synonym: Nonaoxyethylene monododecyl ether,Polidocanol,聚醚醇

Target: Others

Gel filtration medium G-100

Cat.No: T41039

S-trityl-L-Cysteine

Cat.No: T36816

Synonym: STLC

Target: Kinesin

Succinimidyl 7-methoxycoumarin-3-carboxylate

Cat.No: TD0078

Synonym: 7-甲氧基-3-羧基香豆素琥珀酰亚胺酯,7-Methoxycoumarin-3-carboxylic acid, succinimidyl ester

Sucrose-epichlorohydrin copolymer

Cat.No: T40311

Synonym: Sucrose-epichlorohydrin copolymer,Polysucrose 400

Netzahualcoyonol

Cat.No: T24528

6-O-Sulfo-β-cyclodextrin (sodium salt)

Cat.No: T37812

Cat.No: T20229

Synonym: L-(+)-Erythrose

Mal-PEG2-Val-Cit-PABA

Cat.No: T77844

ZK-Thiazolidinone

Cat.No: T68428

Cat.No: T62623

Cat.No: T80761

Cat.No: T82546

α-Cyclodextrin (hydrate)

Cat.No: T35414

Poly-L-lysine hydrochloride

Cat.No: T40240

Target: Antibacterial

Cat.No: T83886

Phosphoramide mustard (cyclohexanamine)

Cat.No: T36701

Cat. No.	Product Name	Target	Signaling Pathways
T19259	D-Desthiobiotin	Endogenous Metabolite	Metabolism
	D-Desthiobiotin 是一种生物素衍生物，用于蛋白质层析和亲和层析，也用于蛋白质和细胞的标记、检测和分离。
T2163	Dihydrocapsaicin CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others; TRP/TRPV Channel	Membrane transporter/Ion channel; Others
	Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素，是TRPV1的选择性激动剂，同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。
TN1102	Physalin L 酸浆苦味素L,酸浆苦味素 L	Others; NO Synthase	Immunology/Inflammation; Others
	Physalin L 抑制巨噬细胞中 LPS 诱导的 NO 生成，平均抑制率是 70.97%。它具有抗炎作用。

天然产物

D-Desthiobiotin

Cat.No: T19259

Target: Endogenous Metabolite

Dihydrocapsaicin

Cat.No: T2163

Synonym: CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

Cat.No: TN1102

Synonym: 酸浆苦味素L,酸浆苦味素 L

Target: Others, NO Synthase

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