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Cat. No.	Product Name	Target	Signaling Pathways
T4574	Sacubitril AHU 377,AHU377,沙库必曲,AHU-377	Neprilysin	Metabolism
	Sacubitril (AHU-377) 是一种有效的NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。
T2318	Sacubitril/Valsartan Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696	Apoptosis; RAAS; Neprilysin	Apoptosis; Endocrinology/Hormones; Metabolism
	Sacubitril/Valsartan (LCZ696)，以1:1摩尔比由Valsartan（一种ARB）和Sacubitril（AHU377）组成，为创新口服血管紧张素受体-脑啡肽酶（ARN）双重抑制剂，旨在治疗高血压与心力衰竭。其作用机制包括抑制炎症、氧化应激及细胞凋亡，有助于改善糖尿病心肌病。
T19114L	Sacubitril-(2S,4S)-Isomer (2S,4S)-Sacubitril,LCZ 696杂质C	Others	Others
	Sacubitril-(2S,4S)-Isomer ((2S,4S)-Sacubitril) 是 Sacubitril 的异构体，它是一种脑啡肽酶抑制剂。
T19112L	Sacubitril Enantiomer 2R,4S-Sacubitril,LCZ 696杂质A,ahu377 isomer 2	Others	Others
	Sacubitril Enantiomer (ahu377 isomer 2) 是 Sacubitril 的对映体，它是一种脑啡肽酶抑制剂。
T4200	Sacubitril hemicalcium salt AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt	Neprilysin	Metabolism
	Sacubitril hemicalcium salt (AHU377 calcium salt) 是一种有效的 NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。
T19112	2R,4S-Sacubitril LCZ 696杂质A,Sacubitril Enantiomer,ahu377 isomer 2	Others	Others
	2R,4S-Sacubitril (Sacubitril Enantiomer) 是 Sacubitri 杂质。其中 Sacubitril 与缬沙坦联合使用，表现出抗心力衰竭的活性。
T19114	(2S,4S)-Sacubitril Sacubitril Impurity C,LCZ 696杂质C	Others	Others
	(2S,4S)-Sacubitril (Sacubitril Impurity C) 是 Sacubitril 的杂质。其中 Sacubitril 是 NEP 抑制剂，可用于研究心力衰竭。
T19111	2R,4R-Sacubitril	Others	Others
	2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.
T19113	2S,4R-Sacubitril	Others	Others
	2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.
T19622	(Z)2S,4R-Sacubitril	Others	Others
	(Z)2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.
T4574L	Sacubitril sodium AHU377,AHU-377,LCZ696,AHU 377
	Sacubitril is an angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases.
TQ0106	Sacubitrilat LBQ-657	Neprilysin	Metabolism
	Sacubitrilat (LBQ-657) 是活性的脑啡肽酶 (NEP) 抑制剂。