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Cat. No.	Product Name	Target	Signaling Pathways
T9039	HIV-1 Nef-IN-1	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	HIV-1 Nef-IN-1 是 HIV-1 Nef 蛋白的抑制剂。它有效地竞争 Nef-SH3Hck 相互作用，Kd 值为 6.7 μM。
T74284	SH379
	SH379为2-甲基嘧啶-稠合三环二萜衍生物，是具有口服活性的有效抗迟发性性腺机能减退剂。它显著促进StAR与3β-HSD等关键睾酮合成相关酶的表达，并通过调节AMPK/mTOR信号通路刺激自噬。
T38387	Compound C108	GTPase	GPCR/G Protein
	Compound C108 是 GTPase 激活蛋白 SH3 结构域结合蛋白 2 (G3BP2) 的抑制剂。 Compound C108可用于乳腺肿瘤和食管鳞状细胞癌的研究。
T4403	AX-024 hydrochloride AX-024 HCl	IL Receptor; TNF; COX; IFNAR; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	AX-024 hydrochloride (AX-024 HCl) 是一种细胞因子释放抑制剂，可强烈抑制 IL-6、TNFα、IFN-γ、IL-10 和 IL-17A 的产生。它是口服可利用的 TCR-Nck 相互作用抑制剂，可选择性地抑制 TCR 触发的 T 细胞活化。它通过靶向 SH3结构域调节细胞信号传导，具有低毒、高效和高选择性的特点。
T37422	Ras Inhibitory Peptide
	Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction ...
T75841	Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA
	Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA（化合物1）是一种与srcSH2域具有高亲和性的五肽，IC50约为1 µM。它同样作为srcSH3-SH2：磷酸蛋白相互作用的抑制剂。
T61071	AX-024
	AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. With an IC50 value of approximately 1 nM, AX-024 effectively modulates cell signaling by specifically targeting SH3 domains. Additionally, AX-024 demonstrates desirable characteristics such as low acute toxicity, high potency, and excellent selectivity. Notably, it exhibits strong ...

化合物

Cat.No: T9039

Target: HIV Protease

Cat.No: T74284

Cat.No: T38387

Target: GTPase

AX-024 hydrochloride

Cat.No: T4403

Synonym: AX-024 HCl

Target: IL Receptor, TNF, COX, IFNAR, Interleukin

Ras Inhibitory Peptide

Cat.No: T37422

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA

Cat.No: T75841

Cat.No: T61071

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