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Search Results for " sglt1 "

21

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39966	SGLT1/2-IN-2 SGLT1/2-IN-2
	SGLT1/2-IN-2 is a chemical compound with robust dual inhibitory properties, exhibiting potent activities against SGLT1 (IC50 = 96 nM) and SGLT2 (IC50 = 1.3 nM).
T62830	SGLT1/2-IN-1
	SGLT1/2-IN-1 是一种 SGLT1/SGLT2 双重抑制剂.
T9590	T-1095	SGLT; transporter	GPCR/G Protein; Metabolism
	T-1095 是一种口服有活性的Na+-葡萄糖协同转运蛋白选择性抑制剂，能够抑制 SGLT1 (IC50:22.8 µm) 及 SGLT2 (IC50:2.3 µm) 。它可用于研究糖尿病。
T15656	KGA-2727	SGLT	GPCR/G Protein
	KGA-2727是选择性，高亲和力和口服有效的 SGLT1抑制剂，对人和大鼠 SGLT1的 Ki 分别为 97.4 nM 和 43.5 nM，对 SGLT1的选择性比人SGLT2 高 140 倍，大鼠SGLT2高390 倍。KGA-2727具有抗糖尿病活性。
T16083	Mizagliflozin GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base	SGLT	GPCR/G Protein
	Mizagliflozin (GSK-1614235 free base) 是口服有效的、选择性的 SGLT1抑制剂，对人 SGLT1 的 Ki 值为 27 nM。Mizagliflozin 对 SGLT1 的选择性是 SGLT2的303 倍。它是抗糖尿病药物，可以改善餐后血糖波动。它在改善慢性便秘方面具有潜在的作用。
T3547	Sotagliflozin LX-4211,LP-802034	SGLT	GPCR/G Protein
	Sotagliflozin (LP-802034) 是有效的SGLT1/2抑制剂，用作抗糖尿病剂。
T8753	LX-2761 intermediate	Others	Others
	LX-2761 intermediate 是LX-2761的合成中间体。LX-2761是一种化学稳定且有效的SGLT1/2抑制剂。
T8750	LX-4211 intermediate	Others	Others
	LX-4211 intermediate 是LX-4211的合成中间体。LX-4211是有效的SGLT1/2抑制剂，用作抗糖尿病剂。
T2385	Ipragliflozin 伊格列净,ASP1941	SGLT	GPCR/G Protein
	Ipragliflozin (ASP1941) 是一种口服有效的，选择性的 SGLT2抑制剂，对人 SGLT2 和 SGLT1，大鼠 SGLT2 和 SGLT1，小鼠 SGLT2 和 SGLT1 的 IC50分别为 7.38 和 1876 nM，6.73 和 1166 nM，5.64 和 1380 nM。Ipragliflozin 具有抗糖尿病活性。
T7217	Bexagliflozin THR-1442,EGT1442,EGT0001442	SGLT	GPCR/G Protein
	Bexagliflozin (EGT1442) 是一种选择性的，口服有效的钠葡萄糖协同转运蛋白-2 (SGLT2) 抑制剂，对人 SGLT2 和 SGLT1 作用的 IC50值分别为 2 nM 和 5.6 μM。EGT1442在 2 型糖尿病中有研究价值。
T1782L	Canagliflozin hemihydrate JNJ28431754,TA 7284,TA7284,TA-7284,JNJ 28431754,JNJ-28431754	SGLT	GPCR/G Protein
	Canagliflozin hemihydrate (TA 7284) (JNJ28431754 hemihydrate) 是一种选择性的 SGLT2 抑制剂，作用于表达 mSGLT2，rSGLT2 和 hSGLT2 的 CHO 细胞，IC50 分别为 2 nM，3.7 nM 和 4.4 nM。
T15797	LX2761	Others	Others
	LX2761 is a chemically stable and effective inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 (IC50s: 2.2 nM and 2.7nM for hSGLT1 and hSGLT2). However, it shows specific SGLT1 inhibition in the gastrointestinal (GI) tract.
T12892	SGL5213	SGLT	GPCR/G Protein
	SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM , respectively),and has potential to treat type 2 diabetes.
T34286	Remogliflozin etabonate GSK189075,GSK 189075,GSK-189075A,GSK189075A,GSK-189075,GSK 189075A	SGLT	GPCR/G Protein
	Remogliflozin etabonate (GSK189075A) 是 regaliflozin 的前药和 SGLT2 抑制剂，对 hSGLT2、rSGLT2、rSGLT1 和 hSGLT1 的 Ki 值分别为 1.95、2.14、8.57 和 43.1μM。
T15752	Licogliflozin LIK066	SGLT	GPCR/G Protein
	Licogliflozin (LIK066) 是钠-葡萄糖协同转运蛋白 (SGLT1和SGLT2) 的有效抑制剂。
T32058	Henagliflozin SHR3824,SHR 3824,SHR-3824
	Henagliflozin (SHR3824) is an effective, oral, and selective SGLT2 inhibitor that effectively inhibits human SGLT2 in vitro, but has very weak inhibitory effects on human SGLT1.
T28659	SAR-7226 Hydrate SAR7226,SAR 7226,SAR-7226
	SAR-7226 Hydrate, a SGLT1/2 inhibitor, is used potentially for the treatment of type 2 diabetes.
T68236	TP0438836
	TP0438836 is a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor for the treatment of type 2 diabetes. TP0438836 showed IC50 values 28nM and 7 nM for hSGLT1 and hSGLT2 resepctively.
T11667	Ipragliflozin (L-Proline) Ipragliflozin L-Proline	Others	Others
	Ipragliflozin is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.
T71340	Mizagliflozin sebacate
	Mizagliflozin sebacate is a sodium-glucose transporter inhibitor. It is expected to improve postprandial hyperglycemia by suppressing glucose absorption from the intestine with a novel mechanism of action different from that of conventional alpha-glucosidase inhibitors. Mizagliflozin blocks intestinal glucose absorption and reduce GIP secretion in rats and humans, suggesting SGLT1 glucose transport is critical for GIP release.
T12893	SGLT inhibitor-1	SGLT	GPCR/G Protein
	SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively).

化合物

Cat.No: T39966

Synonym: SGLT1/2-IN-2

Cat.No: T62830

Cat.No: T9590

Target: SGLT, transporter

Cat.No: T15656

Target: SGLT

Cat.No: T16083

Synonym: GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base

Target: SGLT

Cat.No: T3547

Synonym: LX-4211,LP-802034

Target: SGLT

LX-2761 intermediate

Cat.No: T8753

Target: Others

LX-4211 intermediate

Cat.No: T8750

Target: Others

Cat.No: T2385

Synonym: 伊格列净,ASP1941

Target: SGLT

Cat.No: T7217

Synonym: THR-1442,EGT1442,EGT0001442

Target: SGLT

Canagliflozin hemihydrate

Cat.No: T1782L

Synonym: JNJ28431754,TA 7284,TA7284,TA-7284,JNJ 28431754,JNJ-28431754

Target: SGLT

Cat.No: T15797

Target: Others

Cat.No: T12892

Target: SGLT

Remogliflozin etabonate

Cat.No: T34286

Synonym: GSK189075,GSK 189075,GSK-189075A,GSK189075A,GSK-189075,GSK 189075A

Target: SGLT

Cat.No: T15752

Synonym: LIK066

Target: SGLT

Cat.No: T32058

Synonym: SHR3824,SHR 3824,SHR-3824

SAR-7226 Hydrate

Cat.No: T28659

Synonym: SAR7226,SAR 7226,SAR-7226

Cat.No: T68236

Ipragliflozin (L-Proline)

Cat.No: T11667

Synonym: Ipragliflozin L-Proline

Target: Others

Mizagliflozin sebacate

Cat.No: T71340

SGLT inhibitor-1

Cat.No: T12893

Target: SGLT

Cat. No.	Product Name	Target	Signaling Pathways
T2S0731	Trilobatin 三叶苷,三叶甙,P-Phlorizin	Amylase	Metabolism
	Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂，是一种HIV-1抑制剂，靶向 Gp41 包膜蛋白，具有神经保护作用。它还是SGLT1/2抑制剂，可选择性诱导人肝母细胞瘤细胞增殖。
T2922	Phlorizin Floridzin,根皮甙,根皮苷,NSC 2833,Phloridzin	ATPase; SGLT	GPCR/G Protein; Membrane transporter/Ion channel
	Phlorizin (Phloridzin) 是非选择性的SGLT 抑制剂，也是Na+/K+-ATPase 抑制剂，对于hSGLT1和hSGLT2的Ki 值分别为 300 和 39 nM。

天然产物

Cat.No: T2S0731

Synonym: 三叶苷,三叶甙,P-Phlorizin

Target: Amylase

Cat.No: T2922

Synonym: Floridzin,根皮甙,根皮苷,NSC 2833,Phloridzin

Target: ATPase, SGLT

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