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DNA损伤和修复 内分泌与激素 G蛋白偶联受体 免疫与炎症 JAK/STAT信号通路 MAPK信号通路 离子通道
代谢 微生物学 神经科学 NF-κB信号通路 氧化还原 PI3K/Akt/mTOR信号通路 蛋白酶体
干细胞 蛋白酪氨酸激酶 泛素化 PROTAC 其他
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萝藦科 肉豆蔻科 鸭跖草科 交让木科 三白草科 海桐花科 五味子科 红厚壳科
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基于表型筛选实体化合物活性筛选 细胞增殖检测 细胞周期检测 细胞凋亡检测 药代动力学研究
药物设计和结构优化 化合物定制合成 分子砌块 网络药理学平台 软件平台
细胞因子和生长因子 •   细胞因子 •   生长因子 受体蛋白 •   Fc 受体 •   细胞因子和生长因子受体
CD 蛋白 •   T 细胞 CD 蛋白 •   B 细胞 CD 蛋白 免疫检查点蛋白 •   抑制性免疫检查点蛋白 •   刺激性免疫检查点蛋白
CAR-T 细胞治疗靶点蛋白 •   血液恶性肿瘤靶点蛋白 •   实体瘤靶点蛋白 酶 •   氧化还原酶 •   转移酶
病毒蛋白 •   冠状病毒蛋白 •   流感病毒蛋白 荧光蛋白 其他蛋白

搜索结果

Search Results for " secret "
Targets Recommended: Beta-Secretase Gamma-secretase Glucagon Receptor

37

抑制剂 & 化合物

1

TargetMol 试剂盒

11

重组蛋白

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Cat. No. Product Name Form Specificity Of Inhibition
CL0149 β-/γ-secretase inhibitor kit

β-/γ-secretase inhibitor kit

TargetMol 试剂盒

β-/γ-secretase inhibitor kit
Cat.No: CL0149
Cat. No. Product Name Target Signaling Pathways
TP1039 Secretin (33-59), rat

大鼠SECRETIN肽,Secretin (rat)

 Glucagon Receptor GPCR/G Protein
Secretin (33-59), rat (Secretin (rat)) 是由 27 个氨基酸组成的多肽。Secretin (33-59), rat 可作用于分泌素受体，能够增强胰腺的碳酸盐、酶和钾离子的分泌。
T3521 γ-Secretase-IN-1

Compound E

 Beta Amyloid; Gamma-secretase Neuroscience; Proteases/Proteasome; Stem Cells
γ-Secretase-IN-1 是一种高效的 γ-secretase 抑制剂，对T-47D 细胞显示部分抗增殖活性且抑制 β-amyloid(40)，β-amyloid(42)，和Notch γ-分泌酶裂解。
T62263 γ-Secretase modulator 13

Gamma-secretase Neuroscience; Proteases/Proteasome; Stem Cells
γ-Secretase modulator 13 是一种 γ-分泌酶调节剂 (GSMs)，可以抑制淀粉样蛋白 β 肽Aβ42 的产生，可以用于研究阿尔茨海默病和肿瘤。
TP1597L Secretoneurin, rat acetate

Secretoneurin, rat acetate(149146-12-3 Free base)

 Others Others
Secretoneurin, rat acetate 是一种 33 个氨基酸的多肽，由分泌粒蛋白 II (SgII) 的蛋白水解加工产生。它在体内和体外诱导大鼠纹状体中的多巴胺释放，它对单核细胞和嗜酸性粒细胞有很强的趋化作用，但对粒细胞没有。
T11358 gamma-secretase modulator 1

N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine

 Gamma-secretase Neuroscience; Proteases/Proteasome; Stem Cells
gamma-secretase modulator 1 是一种 γ 分泌酶的调节剂，可用于治疗阿尔茨海默病的研究。
T9713 δ-secretase inhibitor 11

Beta Amyloid; Caspase Apoptosis; Neuroscience; Proteases/Proteasome
δ-secretase inhibitor 11是一种分泌酶抑制剂，可用作 阿尔茨海默病（AD） 治疗转化开发的先导化合物。
T11361 γ-Secretase modulator 4

Others Others
γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.
TP1136 Secretin (28-54), human

Human secretin
Secretin (28-54), human, is a 27-amino acid residue peptide with a C-terminal amidation, acting on human secretin receptors.
T75973 Secretin, porcine TFA

Porcine secretin TFA (Porcine secretin TFA) 是一种含有27个氨基酸的多肽，能够影响胰腺腺泡细胞和导管上皮细胞，促进碳酸氢盐丰富的流体生成。
T75863 Secretin (33-59), rat TFA

Secretin (33-59), rat (TFA) 为含27个氨基酸的多肽，针对分泌素 (secretin) 受体具有特异性作用，主要促进胰腺分泌碳酸盐、酶及钾离子。
TP1048 Secretin, porcine

Porcine secretin acetate
Secretin, porcine (Porcine secretin acetate) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid. Secretin porcine stimulates pancreatic and gastric secretions to a
TP1047 Secretin, porcine TFA (17034-34-3 free base)

Porcine secretin TFA,Secretin, porcine TFA
Secretin, porcine TFA (Porcine secretin TFA) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid.Secretin porcine stimulates pancreatic and gastric secretions to ai
TP1610 Secretin, canine

Secretin is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Canine secretin can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.
T61881 γ-Secretase modulator 12

γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM. It is specifically designed for Alzheimer's disease research. Notably, γ-Secretase modulator 12 exhibits a favorable brain/plasma ratio (Kp, brain = 0.72) in mice [1].
T3161 β-Secretase inhibitor-STA

Beta-Secretase Neuroscience
BACE-IN-1 是淀粉样前体蛋白 β-分泌酶抑制剂。
T64258 gamma-secretase modulator 5

gamma-secretase modulator 5 (compound 22d) 是一种能够透过血脑屏障的 γ-分泌酶调节剂 (GSMs)，对聚集的淀粉样蛋白 β 肽 Aβ42 的产生表现出抑制作用 (IC50: 60 nM)。gamma-secretase modulator 5 能够用于研究阿尔茨海默病。
T11362 gamma-Secretase Modulators

γ-Secretase Modulators,Amyloid-β production inhibitor

 Others Others
gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.
T11359 gamma-secretase modulator 2

Others Others
gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease .γ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretase modulator is usful in particular Alzheimer's disease.
TP1038 Secretin (33-59), rat TFA (121028-49-7 free base)

Secretin (33-59), rat TFA,Secretin (rat) (TFA)
Secretin (33-59), rat (TFA) is a 27-aa peptide, which acts on secretin receptor, and enhances the secretion of bicarbonate, enzymes, and K+ from the pancreas[1][2].
TP1135 Secretin (28-54), human TFA

Human secretin TFA
Secretin (28-54), human TFA is a 27-amino acid peptide that works on the human Secretin receptor.
T13434 β-Secretase Inhibitor IV

Others Others
β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively).
T40260 β-Secretase Inhibitor II

β-Secretase Inhibitor II is a tripeptide aldehyde compound that acts as an inhibitor of β-Secretase. It exhibits a simple structure and has an inhibitory potency of IC50 = 700 nM against total Aβ and IC50 = 2.5 μM specifically against Aβ 1-42. This compound is particularly useful in research related to Alzheimer's disease.
T39089 Acid secretion-IN-1

Acid secretion-IN-1, a polycyclic compound, is synthesized for its application as an IDO inhibitor in synthetic experiments.
T62455 β-Secretase Inhibitor III

β-Secretase Inhibitor III 是一种高度选择性的 BACE1 抑制剂，其 Ki 值为 0.13 nM。
T65428 Secretin,porcine

Secretin,porcine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T65428。
T11358L gamma-secretase modulator 1 hydrochloride

gamma-secretase modulator 1 hydrochloride (1172637-87-4 free base)

 Others Others
gamma-secretase inhibitior-1 是γ-secretase 调节剂，gamma-secretase inhibitior-1可用于阿尔茨海默病。
T10064 LH secretion antagonist 1

Others Others
LH secretion antagonist 1 is an antagonist of luteinizing hormone secretion with analgesic activity.
T64685 Secretin xAcetate

Secretin xAcetate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64685。
T40315 γ-Secretase modulator 10

γ-Secretase modulator 10 is a novel γ-secretase modulator.
T34600 Secretin (1-6)

Secretin,N-terminal hexapeptide
Secretin (1-6) is the N-terminal part of secretin. It can produce vitro glucose-dependent insulin release induced by secretin.
TP1597 Secretoneurin, rat

Secretoneurin, rat, a 33-amino acid polypeptide, is generated by proteolytic processing of secretogranin II (SgII).
T11360 gamma-secretase modulator 3

Others Others
gamma-secretase modulator 3 is a gamma-secretase modulator.
T63638 γ-Secretase modulator 11 hydrochloride

γ-Secretase modulator 11 hydrochloride 是有效的、口服具有活力的 γ-secretase 调节剂 (IC50: 0.029 μM)。 γ-Secretase modulator 11 hydrochloride 能够明显降低脑 Aβ42 水平，可挽救 AD 模型小鼠表现出的认知缺陷。γ-Secretase modulator 11 hydrochloride 对阿尔茨海默病表现出研究潜力。
T63216 γ-Secretase modulator 11

5-{8-[（3，4'-二氟[1，1'-联苯]-4-基）甲氧基]-2-甲基咪唑并[1，2-a]吡啶-3-基}-N-甲基吡啶-2-甲酰胺（1o）具有较高的体外效力和脑暴露效果，能够使脑Aβ42水平的明显降低，且对细胞色素p450酶无抑制作用。此外，化合物1o 在AD 模型小鼠中表现出优异的抗认知缺陷作用。
T39251 β-Secretase Inhibitor I

β-Secretase Inhibitor I is a highly potent inhibitor of the β-secretase enzyme. This compound exhibits exceptional inhibitory activity while also demonstrating a significant reduction in cardiovascular and liver toxicity.
T81182 Secretin (swine)

Secretin (swine)为源自猪的神经内分泌激素，由十二指肠黏膜S细胞产生，具有27个氨基酸的多肽结构，并针对分泌素受体起作用。此激素在各类成熟肠内分泌细胞亚群中表达，受脂肪酸的促进。它主要激发胰腺释放水和碳酸氢盐，同时在消化系统、中枢神经系统和能量代谢方面具有广泛应用。
TP1144L Corticotropin-releasing factor (human) acetate

Corticotropin-releasing factor (human) acetate (86784-80-7 Free base)

 CRFR GPCR/G Protein
Corticotropin-releasing factor (human) acetate 刺激垂体前叶合成和分泌促肾上腺皮质激素。

化合物

Secretin (33-59), rat
Cat.No: TP1039
Synonym: 大鼠SECRETIN肽,Secretin (rat)
Target: Glucagon Receptor
γ-Secretase-IN-1
Cat.No: T3521
Synonym: Compound E
Target: Beta Amyloid, Gamma-secretase
γ-Secretase modulator 13
Cat.No: T62263
Synonym:
Target: Gamma-secretase
Secretoneurin, rat acetate
Cat.No: TP1597L
Synonym: Secretoneurin, rat acetate(149146-12-3 Free base)
Target: Others
gamma-secretase modulator 1
Cat.No: T11358
Synonym: N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine
Target: Gamma-secretase
δ-secretase inhibitor 11
Cat.No: T9713
Synonym:
Target: Beta Amyloid, Caspase
γ-Secretase modulator 4
Cat.No: T11361
Synonym:
Target: Others
Secretin (28-54), human
Cat.No: TP1136
Synonym: Human secretin
Target:
Secretin, porcine TFA
Cat.No: T75973
Synonym:
Target:
Secretin (33-59), rat TFA
Cat.No: T75863
Synonym:
Target:
Secretin, porcine
Cat.No: TP1048
Synonym: Porcine secretin acetate
Target:
Secretin, porcine TFA (17034-34-3 free base)
Cat.No: TP1047
Synonym: Porcine secretin TFA,Secretin, porcine TFA
Target:
Secretin, canine
Cat.No: TP1610
Synonym:
Target:
γ-Secretase modulator 12
Cat.No: T61881
Synonym:
Target:
β-Secretase inhibitor-STA
Cat.No: T3161
Synonym:
Target: Beta-Secretase
gamma-secretase modulator 5
Cat.No: T64258
Synonym:
Target:
gamma-Secretase Modulators
Cat.No: T11362
Synonym: γ-Secretase Modulators,Amyloid-β production inhibitor
Target: Others
gamma-secretase modulator 2
Cat.No: T11359
Synonym:
Target: Others
Secretin (33-59), rat TFA (121028-49-7 free base)
Cat.No: TP1038
Synonym: Secretin (33-59), rat TFA,Secretin (rat) (TFA)
Target:
Secretin (28-54), human TFA
Cat.No: TP1135
Synonym: Human secretin TFA
Target:
β-Secretase Inhibitor IV
Cat.No: T13434
Synonym:
Target: Others
β-Secretase Inhibitor II
Cat.No: T40260
Synonym:
Target:
Acid secretion-IN-1
Cat.No: T39089
Synonym:
Target:
β-Secretase Inhibitor III
Cat.No: T62455
Synonym:
Target:
Secretin,porcine
Cat.No: T65428
Synonym:
Target:
gamma-secretase modulator 1 hydrochloride
Cat.No: T11358L
Synonym: gamma-secretase modulator 1 hydrochloride (1172637-87-4 free base)
Target: Others
LH secretion antagonist 1
Cat.No: T10064
Synonym:
Target: Others
Secretin xAcetate
Cat.No: T64685
Synonym:
Target:
γ-Secretase modulator 10
Cat.No: T40315
Synonym:
Target:
Secretin (1-6)
Cat.No: T34600
Synonym: Secretin,N-terminal hexapeptide
Target:
Secretoneurin, rat
Cat.No: TP1597
Synonym:
Target:
gamma-secretase modulator 3
Cat.No: T11360
Synonym:
Target: Others
γ-Secretase modulator 11 hydrochloride
Cat.No: T63638
Synonym:
Target:
γ-Secretase modulator 11
Cat.No: T63216
Synonym:
Target:
β-Secretase Inhibitor I
Cat.No: T39251
Synonym:
Target:
Secretin (swine)
Cat.No: T81182
Synonym:
Target:
Corticotropin-releasing factor (human) acetate
Cat.No: TP1144L
Synonym: Corticotropin-releasing factor (human) acetate (86784-80-7 Free base)
Target: CRFR
Species：
Human (6)
Burkholderia thailandensis (1)
Cynomolgus (1)
HEV-1 (1)
Mouse (1)
Rat (1)
Expression System：
HEK293 Cells (5)
E. coli (4)
Baculovirus Insect Cells (1)
P. pastoris (Yeast) (1)
Tag：
C-His (5)
N-6xHis-GST (2)
His (1)
N-10xHis (1)
N-10xHis, C-Myc (1)
N-6xHis (1)
Cat. No. Product Name Species Expression System
TMPY-01875 SCGN Protein, Human, Recombinant (His)

SEGN,SECRET,DJ501N12.8,CALBL,secretagogin,...

 Human E. coli
Secretagogin, also known as SCGN, is a secreted protein that is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin / SCGN is restricted to distinct subtypes ...
TMPH-00319 Type III secretion system needle Protein, Burkholderia thailandensis, Recombinant (His)

Burkholderia thailandensis P. pastoris (Yeast)
Type III secretion system needle Protein, Burkholderia thailandensis, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 11.9 kDa and the accession number is Q2T727.
TMPK-00673 SG3/Secretogranin 3 Protein, Cynomolgus, Recombinant (His)

SCG3,Secretogranin-3,UNQ2502/PRO5990,SGIII,Secr...

 Cynomolgus HEK293 Cells
Secretogranin III (Scg3) is a member of the granin protein family that regulates the biogenesis of secretory granules. Scg3 was recently discovered as an angiogenic factor, expanding its functional role to extrinsic regulation. Unlike many other known angiogenic factors, the pro-angiogenic actions of Scg3 are restricted to pathological conditions. Among thousands of quantified endothelial ligands, Scg3 has the highest binding activity ratio to diabetic vs. SG3/Secretogranin 3 Protein, Cynomolgus...
TMPH-00813 Hepatitis E virus genotype 1 (HEV-1) Secreted protein ORF2 (His)

HEV-1 Baculovirus Insect Cells
Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.; Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation. Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry. Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes. Hepatitis E virus gen...
TMPH-02068 Secretogranin-1 Protein, Human, Recombinant (GST & His)

Human E. coli
Secretogranin-1 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
TMPH-03368 SG3/Secretogranin 3 Protein, Rat, Recombinant (His & Myc)

Rat E. coli
Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway. SG3/Secretogranin 3 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 58.2 kDa and the accessio...
TMPK-01122 SG3/Secretogranin 3 Protein, Human, Recombinant (aa 20-468, His)

SCG3,Secretogranin III,UNQ2502/PRO5990,Secret

Human HEK293 Cells
Secretogranin III (Scg3) is a member of the granin protein family that regulates the biogenesis of secretory granules. Scg3 was recently discovered as an angiogenic factor, expanding its functional role to extrinsic regulation. Unlike many other known angiogenic factors, the pro-angiogenic actions of Scg3 are restricted to pathological conditions. Among thousands of quantified endothelial ligands, Scg3 has the highest binding activity ratio to diabetic vs. SG3/Secretogranin 3 Protein, Human, Rec...
TMPY-04675 SG3/Secretogranin 3, Mouse, Recombinant (His)

AI385542,SgIII,1B1075,Chgd,secretogranin III

 Mouse HEK293 Cells
SG3/Secretogranin 3, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.4 kDa and the accession number is P47867-1.
TMPY-03968 Secretogranin II Protein, Human, Recombinant (His)

EM66,SgII,SN,CHGC,secretogranin II

 Human HEK293 Cells
Kit ligand, also known as Hematopoietic growth factor KL, Mast cell growth factor, Steel factor, Stem cell factor, c-Kit ligand, Kitlg and KITL, is a single-pass type I membrane protein that belongs to the SCF family. KITL / kit ligand also belongs to the family of dimeric transmembrane growth factors. The soluble form of KIT ligand is a secreted protein. Mast cells are thought to participate in a variety of immune responses, such as parasite resistance and the allergic reaction. Mast cell devel...
TMPY-03994 SG3/Secretogranin 3 Protein, Human, Recombinant (His)

secretogranin III,SGIII,UNQ2502/PRO5990

 Human HEK293 Cells
SG3/Secretogranin 3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.4 kDa and the accession number is AAH14539.1.
TMPH-02069 Secretogranin-2 Protein, Human, Recombinant (GST & His)

Human E. coli
Secretogranin-2 Protein, Human, Recombinant (GST & His) is expressed in E. coli.

重组蛋白

SCGN Protein, Human, Recombinant (His)
Cat.No: TMPY-01875
Species: Human
Expression System: E. coli
Type III secretion system needle Protein, Burkholderia thailandensis, Recombinant (His)
Cat.No: TMPH-00319
Species: Burkholderia thailandensis
Expression System: P. pastoris (Yeast)
SG3/Secretogranin 3 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00673
Species: Cynomolgus
Expression System: HEK293 Cells
Hepatitis E virus genotype 1 (HEV-1) Secreted protein ORF2 (His)
Cat.No: TMPH-00813
Species: HEV-1
Expression System: Baculovirus Insect Cells
Secretogranin-1 Protein, Human, Recombinant (GST & His)
Cat.No: TMPH-02068
Species: Human
Expression System: E. coli
SG3/Secretogranin 3 Protein, Rat, Recombinant (His & Myc)
Cat.No: TMPH-03368
Species: Rat
Expression System: E. coli
SG3/Secretogranin 3 Protein, Human, Recombinant (aa 20-468, His)
Cat.No: TMPK-01122
Species: Human
Expression System: HEK293 Cells
SG3/Secretogranin 3, Mouse, Recombinant (His)
Cat.No: TMPY-04675
Species: Mouse
Expression System: HEK293 Cells
Secretogranin II Protein, Human, Recombinant (His)
Cat.No: TMPY-03968
Species: Human
Expression System: HEK293 Cells
SG3/Secretogranin 3 Protein, Human, Recombinant (His)
Cat.No: TMPY-03994
Species: Human
Expression System: HEK293 Cells
Secretogranin-2 Protein, Human, Recombinant (GST & His)
Cat.No: TMPH-02069
Species: Human
Expression System: E. coli
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