31
5
Cat. No. | Product Name | Target | Signaling Pathways |
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TP2116 |
SAH-SOS1A
|
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KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Display | |||
TP2115 |
SAH-EZH2
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EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line. | |||
T27056 |
CN-SAH
CNSAH |
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CN-SAH is a potent and selective inhibitor of DOT1L. | |||
T76059 |
SAH-SOS1A TFA
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SAH-SOS1A TFA 是一种基于肽的SOS1/KRAS 蛋白相互作用抑制剂。SAH-SOS1A TFA 以纳摩尔亲和力 (EC50=106-175 nM) 与野生型和突变型 KRAS (G12D, G12V, G12C, G12S, Q61H) 结合,直接和独立地阻断核苷酸结合。SAH-SOS1A TFA 损害 KRAS 驱动的癌细胞活力,并通过阻断 KRAS 下游 ERK-MAPK 磷酸化信号级联的机制发挥作用。 | |||
T11284 |
FIDAS-3
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Others; Wnt/beta-catenin; Methionine Adenosyltransferase (MAT) | Chromatin/Epigenetic; Cytoskeletal Signaling; Others; Stem Cells |
FIDAS-3 是一种强效Wnt 抑制剂,也是一种二苯乙烯衍生物,对甲硫氨酸腺苷转移酶 2A (MAT2A) 的IC50为 4.9 μM。它能够与 S-腺苷甲硫氨酸有效竞争MAT2A 结合,并具有抗癌作用。 | |||
T21902 |
ML351
|
Lipoxygenase | Metabolism |
ML351 是一种高度特异的15-LOX-1抑制剂,其 IC50=200 nM。它对 T1D 非肥胖糖尿病小鼠模型的血糖异常和β细胞氧化应激有抑制作用。它对相关同工酶 (5-LOX、血小板 12-LOX、15-LOX-2、绵羊 COX-1 和人 COX-2) 表现出良好的选择性(>250倍)。 | |||
T11285 |
FIDAS-5
|
Others | Others |
FIDAS-5 是甲硫氨酸腺苷转移酶 2A 抑制剂(IC50:2.1 μM),具有口服活性。它能够与 S-腺苷甲硫氨酸有效竞争 MAT2A 结合,并具有抗癌作用。 | |||
T12908 |
SIBA
5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine,5ˊ-异丁硫基-5ˊ-脱氧腺苷 |
Nucleoside Antimetabolite/Analog; HSV | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
SIBA (5'-Deoxy-5'-isobutylthioadenosine) 是 SAH 的合成类似物,可作为 S-腺苷甲硫氨酸介导的甲基转移的抑制剂。它干扰多种酶活性,可逆地阻断单纯疱疹病毒 1 型病毒的繁殖。 | |||
T11571 |
HLY78
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) 是 Wnt/β-catenin 信号通路的激活剂,通过靶向通道中 Axin 的 DIX 域,增强 Axin-LRP6 交联,诱导 Wnt 信号转导。 | |||
T19294 |
Docosahexaenoic Acid methyl ester
二十二六烯酸甲酯,Methyl docosahexaenoate,all cis-DHA methyl ester |
Others | Others |
Docosahexaenoic Acid methyl ester (all cis-DHA methyl ester) 是甲基化的二十二碳六烯酸类似物,能够插入膜磷脂中而不被氧化或水解。 | |||
T8800 |
NSAH
2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) 是一种可逆竞争性非核苷类的核苷酸还原酶抑制剂,无细胞 IC50 为 32 μM,基于细胞的 IC50 约为 250 nM。 | |||
T76054 |
SAHM1 TFA
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SAHM1 TFA is a chemical compound that acts as a Notch pathway inhibitor by stabilizing a hydrocarbon-stapled alpha helical peptide. It specifically targets the protein-protein interface, effectively preventing the assembly of the Notch complex. | |||
TP2117 |
SAHM1
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Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly. | |||
T19556 |
SAHA chloroalkane T1
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Others | Others |
SAHA chloroalkane T1 is a novel compound formed by combining Vorinostat (SAHA) with a chloroalkane capture tag, referred to as T1. This innovative approach involves tethering the SAHA molecule with the T1 tag, resulting in the formation of SAHA chloroalkane T1. | |||
T38218 |
1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
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1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 是一种在生物膜中的磷脂,在 sn-1 和 sn-2 位置分别含有硬脂酸和二十二碳六烯酸。它已被用于研究脂膜的组织和动力学。在超氧化物歧化酶 1 突变体转基因小鼠肌萎缩性脊髓侧索硬化症(ALS)模型中1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 的水平在疾病晚期会在 L5 前角下降。1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 可用于研究生物膜。 | |||
T38028 |
(R)-(+)-Docosahexaenyl-1'-Hydroxy-2'-Propylamide
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N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Docosahexaenoyl ethanolamide (DHEA) has potential signaling roles in cancer, inflammation, and neurological development and functioning. At least some of DHEA's effects are mediated through cannabinoid (CB) receptors, while some NAEs also act as vanilloid receptor agonists and voltage-gated K+ channel blockers. (R)-(+)-Docosahexaenyl-1'-hydroxy-2'-propylamide is a homolog of DHEA,... | |||
T35767 |
SAHO2
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SAHO2is a sulfone form of the methyl donor S-(5'-adenosyl)-L-methionine chloride and is a substrate for radical SAM enzymes.1It is reductively cleaved to 5'-deoxyadenosine and 5'-thioadenosine sulfinic acid by the radical SAM enzymes NosL or NosN. 1.Mandalapu, D., Ji, X., and Zhang, Q.Reductive cleavage of sulfoxide and sulfone by two radical S-adenosyl-L-methionine enzymesBiochemistry58(1)36-39(2019) | |||
T74757 |
Didocosahexaenoin
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Didocosahexaenoin 是一种 omega-3 衍生物,是 DHA 的甘油二酯,可由 DHA 甘油三酯合成。Didocosahexaenoin 导致线粒体膜电位显着丧失并诱导 ROS 产生。Didocosahexaenoin 诱导细胞凋亡。Didocosahexaenoin 在人前列腺癌细胞中诱导比 DHA 更强的细胞毒性。 | |||
T21749 |
4-iodo-SAHA
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4-Iodo-SAHA (1k) 是一种具有口服活性的I 类和II 类histone deacetylase (HDAC)抑制剂,对 Skbr3、 HT29、 U937、 JA16 和 HL60细胞的EC50值分别为1.1、0.95、0.12、0.24、0.85和1.3 μM。4-Iodo-SAHA (1k) 可用于癌症的研究。 | |||
T41321 |
Docosahexaenoic acid ethyl ester
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T71011 | Perfluorinated SAHA | ||
Perfluorinated SAHA is an HDAC inhibitor for use in cancer treatment regimens, with demonstrated greater antiproliferative properties than SAHA . PFSAHA has also been shown to have higher selectivity for PA3774, an HDAC-like enzyme from P. aeruginosa, as well as other HDACs, which may prove beneficial for developing novel chemotherapeutic treatments for cancer. | |||
T36105 |
coumarin-SAHA
coumarin-Suberoylanilide Hydroxamic Acid,coumarin-SAHA |
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Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm | |||
T36868 |
4-oxo Docosahexaenoic Acid
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4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 μM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 μM. | |||
T35766 |
SAHO
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SAHO is a sulfoxide form of the methyl donor S-(5'-adenosyl)-L-methionine chloride and a substrate for radical SAM enzymes.1It is reductively cleaved to S-adenosylhomocysteine , 5'-deoxyadenosine , and 5'-thioadenosine sulfenic acid by the radical SAM enzymes NosL or NosN. 1.Mandalapu, D., Ji, X., and Zhang, Q.Reductive cleavage of sulfoxide and sulfone by two radical S-adenosyl-L-methionine enzymesBiochemistry58(1)36-39(2019) | |||
T37633 |
17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
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17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM). | |||
T73454 | SAHA-OH | HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SAHA-OH为HDAC6选择性抑制剂(IC50=23 nM),对HDAC6具有10至47倍选择性,相较于HDAC1、2、3及8。该化合物展现抗炎活性,能够降低巨噬细胞凋亡。 | |||
T37532 |
Docosahexaenoyl Glycine
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The ω-3 polyunsaturated fatty acids (PUFAs) found in fish oils provide cardiovascular benefits. Docosahexaenoic acid (DHA), a C22:6 PUFA, is the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. It can be synthesized from other dietary ω-3 PUFAs or taken as a nutritional supplement. Docosahexaenoyl glycine consists of DHA with glycine attached at its carboxy terminus. | |||
T35765 |
SAHA-BPyne
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Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag intended to be used for profiling HDAC activities in proteomes and live cells. Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azi... | |||
T77230 |
1-O-Hexadecyl-2-O-docosahexaenoyl-sn-glycero-3-phosphorylcholine
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1-O-Hexadecyl-2-O-docosahexaenoyl-sn-glycero-3-phosphorylcholine为存在于尿中的内源性代谢物,用于肥胖研究。 | |||
T70186 |
Methazolamide-d6
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Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and re... | |||
T74764 | Adenosylhomocysteinase | ||
Adenosylhomocysteinase (SAHH; AHCY) 是一种高度保守的酶。Adenosylhomocysteinase 可逆催化 S-腺苷同型半胱氨酸 (SAH) 生成腺苷和 L-同型半胱氨酸。血清外泌体 Adenosylhomocysteinase 水平可作为 HBV-LC 患者预后的生物标志物。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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TQ0208 |
SAH
SAH (S-Adenosylhomocysteine),S-(5'-腺苷)-L-高半胱氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
SAH (SAH (S-Adenosylhomocysteine)) 是氨基酸衍生物,是几种代谢途径中的调节剂。SAH 是腺苷和半胱氨酸合成的中间体。SAH 是 METTL3-METTL14 异二聚体复合物的抑制剂,IC50=0.9 µM。 | |||
T5369 |
Docosahexaenoic Acid
Cervonic acid,DHA |
Others; Endogenous Metabolite | Metabolism; Others |
Docosahexaenoic Acid 是一种ω-3脂肪酸,在脑和视网膜中较为丰富,且能够直接从鱼油和母乳中获得。 | |||
T80949 |
Tridocosahexaenoin
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Tridocosahexaenoin 是一种具有抗氧化特性的三酰基甘油。 | |||
TN4933 |
Sahandol
|
Antifection | Microbiology/Virology |
Sahandol shows antiprotozoal activity against P. falciparum and T. brucei rhodesiense. | |||
T12357 |
Palmitoyldocosahexaenoyl phosphatidylcholine
|
Others | Others |
Palmitoyldocosahexaenoyl phosphatidylcholine, an endogenous metabolite. |