Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16156 |
MT 63-78
|
Apoptosis; AMPK; mTOR | Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
MT 63-78 是一种有效的直接AMPK 激活剂,EC50为 25 μM。它诱导细胞有丝分裂阻滞和细胞凋亡,通过抑制脂肪生成和mTORC1途径来阻止前列腺癌的生长,具有抗肿瘤作用。 | |||
T1838 |
Sapanisertib
沙帕色替,TAK-228,MLN0128,INK 128 |
PI3K; mTOR; Autophagy | Autophagy; PI3K/Akt/mTOR signaling |
Sapanisertib (INK 128) 是一种口服有效的 ATP 依赖性的mTOR1/2抑制剂,抑制 mTOR 激酶的IC50值为 1 nM,具有潜在抗肿瘤活性。 | |||
T31223 |
DCBCI0901
DCBCI-0901,DCBCI 0901 |
||
DCBCI0901 is an inhibitor of phosphatidylinositide 3-kinase (PI3K), raptor-mTOR (mTOR complex 1 or mTORC1) and rictor-mTOR (mTOR complex 2 or mTORC2) with potential antineoplastic activity. | |||
T30441 |
BI-860585
BI860585 |
||
BI-860585 is an inhibitor of Raptor-Mammalian Target of Rapamycin (mTOR) Complex 1 (mTOR Complex 1; mTORC1) and rictor-mTOR Complex 2 (mTOR Complex 2; mTORC2), with potential Anti-tumor activity. |