Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21652 |
RN-1 dihydrochloride
|
Histone Demethylase; MAO | Chromatin/Epigenetic; Metabolism; Neuroscience |
RN-1 dihydrochloride 是血脑屏障通透性的、不可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 选择性抑制剂,IC50为 70 nM,对 LSD1 的选择性高于 MAO-A 和 MAO-B,IC50分别为 0.51 μM 和 2.785 μM。 | |||
T9528 |
ARN19702
|
Others | Others |
ARN19702 是一种选择性,具有口服活性的,可逆的,可透过血脑屏障的 N-乙酰乙醇胺酸酰胺酶 (NAAA) 抑制剂,对人 NAAA 的 IC50为 230 nM。ARN19702 具有广泛的镇痛作用。 | |||
T21658 |
ARN14974
|
Others | Others |
ARN14974 是一种有效的全身活性的胞内酸性神经酰胺酶抑制剂 (IC50=79 nM),是一种苯并恶唑酮甲酰胺化合物。 | |||
TQ0015 |
PRN1371
|
c-Fms; FGFR; CSF-1R | Angiogenesis; Tyrosine Kinase/Adaptors |
PRN1371 是一种高效的、选择性的FGFR1-4和CSF1R 抑制剂,对FGFR1,FGFR2,FGFR3,FGFR4 和 CSF1R 的IC50值分别为 0.6,1.3,4.1,19.3 和 8.1 nM。 | |||
T30137 |
ARN14686
|
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ARN14686 is an activity-based affinity probe for the detection of N-acylethanolamine acid amidase (NAAA) using click chemistry. | |||
T39859 | ARN19689 | ||
ARN19689 is an effective inhibitor of human NAAA, demonstrating high potency in the low nanomolar range (IC 50 = 0.042 μM). The compound acts through a non-covalent mechanism, highlighting its ability to interact with the enzyme for inhibition. | |||
T14321 |
ARN19874
|
Others | Others |
ARN19874 is a selective, reversible uncompetitive N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) activity inhibitor. With an IC50 of ~34 μM[1]. | |||
T36468 |
ARN14988
|
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ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively). | |||
T61256 |
ARN1468
|
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ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1]. |