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27

抑制剂 & 化合物

35

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T125940	Penicilliumin A
	Penicilliumin A 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125940，CAS号为 1393131-81-1。
T124797	Ochratoxin B	Endogenous Metabolite	Metabolism
	Ochratoxin B 由多种曲霉和青霉菌产生的，是霉菌毒素 Ochratoxin A 的类似物，会对农产品造成污染。
T27300	Olorofim Olorofim,F901318,F-901318
	Olorofim 是一种新型的选择性抗真菌化合物，对烟曲霉DHODH 具有抑制作用（IC50：44 nM），对人类DHODH 几乎没有抑制作用（>100 uM）。Olorofim 对青霉菌属、皮炎杆菌属、镰刀菌属等各种致病性丝状和二形真菌有很好的疗效。
T29345	2-Ethyl-5-methylphenol	Others	Others
	2-Ethyl-5-methylphenol 是一种烷基苯酚，可从金黄色青霉、疣状假单胞菌和绿色青霉中分离或鉴定的化合物。
T32262	Janthitrem G
	Janthitrem G is a type of naphthopyran. Janthitrem G is obtained from Penicillium janthinellum. Tremorgenic mycotoxi.
T31761	Fellutamide A
	Fellutamide A as a tripeptide derivative from Penicillium fellutanum can enhance nerve growth factor (NGF) synthesis and secretion in vitro.
T34444	Rubroskyrin
	Rubroskyrin is a modified bis-anthraquinone pigment that comes from Penicillium islandicum Sopp.
T32982	Luteoskyrin Flavomycelin
	Luteoskyrin is a hepatotoxic and hepatocarcinogenic bisdihydroanthraquinone produced by Penicillium islandicum Sopp.
T34717	Stevastelin B3 NK374186B3,NK 374186B3,Antibiotic NK 374186B3,NK-374186B3
	Stevastelin B3 is a depsipeptide isolated from Penicillium.
T34447	Rugulin
	Rugulin is a minor metabolite from Penicillium rugulosum and a naturally occurring bisanthraquinone.
T38315	Penigequinolone A
	Penigequinolone A 可由 Penicillium sp., No. 410 产生，具有花粉生长抑制剂作用。
T34190	Puberuline Fructigenine A,Rugulosuvine-B,Fructigenine-A,Rugulosuvine B,Puberulin
	Puberuline is a diketopiperazine alkaloid isolated from Penicillium piscarium.
T32258	Janthitrem B
	Janthitrem B is a trematoxin produced by certain isolates of Penicillium violaceum.
T80312	PAF26
	PAF26为针对植物病原真菌Penicillium digitatum、Penicillium italicum及Botrytis cinerea具有活性的抗菌肽。
T33551	N(alpha)-Acetylfusarinines Nalpha-Acetylfusarinines
	N(alpha)-Acetylfusarinines is a group of naturally occurring hydroxamic acids produced by unidentified species of Penicillium when grown on iron-deficient media.
T32260	Janthitrem E
	Janthitrem E is a type of naphthopyran. Janthitrem E is obtained from Penicillium janthinellum. Tremorgenic mycotoxi.
T32259	Janthitrem C
	Janthitrem c is a type of naphthopyran. Janthitrem C is obtained form Penicillium janthinellum. Tremorgenic mycotoxin.
T32261	Janthitrem F Janthitrem E monoacetate
	Janthitrem f, as a 10-0-acetyljanthitrem e or janthitrem e monoacetate, is a type ofnaphthopyran. Janthitrem F is prepared by Penicillium janthinellum. Tremorgenic mycotoxi.
T37254	Rugulotrosin A
	Rugulotrosin A is an antibiotic originally isolated from Penicillium. It is active against the Gram-positive bacteria E. faecalis, B. cereus, B. subtilis, and S. aureus with 99% lethal dose (LD99) values of 1.6, 3.1, 5.5, and 200 μg/ml, respectively. Rugulotrosin A is inactive against Gram-negative bacteria.
T25170	Botryodiplodin Cytostipin,Antibiotic PSX 1
	Botryodiplodin, an antibiotic, has antileukemic activity from Botryodiplodia theobromae. It has the property of turning the skin of the individual in various shades of pink 2-3 hrs after application. It is a toxic metabolite of Penicillium carneo-lutescen
T36878	Sclerotiorin
	Sclerotiorin is a natural product isolated primarily from Penicillium species. It inhibits soybean lipoxygenase-1 with an IC50 value of 4.2 μM. Sclerotiorin also exhibits a number of other activities including inhibition of cholesterol ester transfer protein (IC50 = 19.4 μM),, inhibition of Grb2-Shc interaction (IC50 = 22 μM),, and antagonism of endothelin receptors (IC50 = 114 and 152 μM for human ETA and ETB, respectively).
T38255	Penipurdin A
	Penipurdin A is an anthraquinone fungal metabolite originally isolated fromP. purpurogenumthat has antibacterial activity.1,2It is active againstM. tuberculosiswith a MIC value of 25 μg/ml.2 1.Xue, J., Fu, Y., Wu, P., et al.Two new anthraquinones from the soil fungus Penicillium purpurogenum SC0070J. Antibiot. (Tokyo)68(9)598-599(2015) 2.Daengrot, C., Rukachaisirikul, V., Tadpetch, K., et al.Penicillanthone and penicillidic acids A-C from the soil-derived fungus Penicillium aculeatum PSU-RSPG105...
T35909	Penicinoline
	Penicinoline is an alkaloid that has been found in Penicillium and has antimalarial, insecticidal, and anticancer activities.1,2 It is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50 = 25 μM for both).1 Penicinoline (1,000 ppm) is also active against the aphid A. gossypii.2 It inhibits proliferation of 95-D and HepG2 cancer cells (IC50s = 0.57 and 6.5 μg/ml, respectively) but not HeLa, KB, KBv200, or Hep-2 cells (IC50s = >100 μg/ml). \|1. Naveen, B., Ommi, N.B.,...
T38276	Benzomalvin C
	Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/ml in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. It was isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.
T75444	Peniterphenyl A
	Peniterphenyl A，一种源于深海青霉属植物的天然产物，能够抑制HSV-1/2病毒的细胞内入侵。它可能通过与HSV-1/2病毒的糖蛋白D直接相互作用，干扰病毒的吸附和膜融合过程，进而有效阻断病毒感染。因此，Peniterphenyl A是抗HSV-1/2研究领域中一个极具潜力的先导化合物。
T35776	Janthitrem A
	Janthitrem A is a mycotoxin that has been found inP. janthinellum.1It induces tremors in mice and decreases the time to fall from the rotarod when administered at a dose of 4 mg/kg.2Janthitrem A (20 μg/g) also reducesW. cervinatalarvae weight gain and food consumption. 1.Gallagher, R.T., Latch, G.C., and Keogh, R.G.The janthitrems: Fluorescent tremorgenic toxins produced by Penicillium janthinellum isolates from ryegrass pasturesAppl. Environ. Microbiol.39(1)272-273(1980) 2.Babu, J.V., Popay, A....
T37288	Remisporine B
	Remisporine B is a polyketide and derivative of remisporine A that has been found inPenicilliumand has immunosuppressant activity.1,2It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 30.1 and 32.4 μg/ml, respectively).1 1.Liu, H., Chen, S., Liu, W., et al.Polyketides with immunosuppressive activities from mangrove endophytic fungus Penicillium sp. ZJ-SY2Mar. Drugs14(12)217(2016) 2.Kong, F., and Carter, G.T.Remisporine B, a novel dimeric chrom...

化合物

Penicilliumin A

Cat.No: T125940

Cat.No: T124797

Target: Endogenous Metabolite

Cat.No: T27300

Synonym: Olorofim,F901318,F-901318

2-Ethyl-5-methylphenol

Cat.No: T29345

Target: Others

Cat.No: T32262

Cat.No: T31761

Cat.No: T34444

Cat.No: T32982

Synonym: Flavomycelin

Cat.No: T34717

Synonym: NK374186B3,NK 374186B3,Antibiotic NK 374186B3,NK-374186B3

Cat.No: T34447

Penigequinolone A

Cat.No: T38315

Cat.No: T34190

Synonym: Fructigenine A,Rugulosuvine-B,Fructigenine-A,Rugulosuvine B,Puberulin

Cat.No: T32258

Cat.No: T80312

N(alpha)-Acetylfusarinines

Cat.No: T33551

Synonym: Nalpha-Acetylfusarinines

Cat.No: T32260

Cat.No: T32259

Cat.No: T32261

Synonym: Janthitrem E monoacetate

Cat.No: T37254

Cat.No: T25170

Synonym: Cytostipin,Antibiotic PSX 1

Cat.No: T36878

Cat.No: T38255

Cat.No: T35909

Cat.No: T38276

Peniterphenyl A

Cat.No: T75444

Cat.No: T35776

Cat.No: T37288

Cat. No.	Product Name	Target	Signaling Pathways
T8693	Diallyl Trisulfide 二烯丙基三硫化物,二烯丙基三硫醚	Apoptosis; Reactive Oxygen Species; Antifungal	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Diallyl Trisulfide 是一种在大蒜中发现的有机多硫化物，可作为 H2S 供体。它抑制扩张性青霉的生长，有抗癌能力。
T3936	PATULIN Expansin,Claviform,散毒素,Clavacin,棒曲霉素	Apoptosis; Others; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; Others
	Patulin (Claviform) 是由 Aspergillus、Penicillium 和 Byssochlamys 几种真菌属产生的霉菌毒素，有致染色体断裂、突变，致畸和细胞毒性作用。它通过溶酶体-线粒体轴诱导自噬依赖性细胞凋亡，能造成 DNA 损伤。
T8335	Lycobetaine acetate 氧化石蒜碱乙酸盐,Oxylycorine	Others	Others
	Lycobetaine acetate (Oxylycorine) 是一种潜在的抗罗克福提青霉和黑曲霉的生物杀菌剂。
T13305	Viridicatol	Anti-infection; Antifungal	Microbiology/Virology
	Viridicatol 是从夹竹桃的内生真菌青霉菌属的发酵中分离出的一种喹诺酮类生物碱，对金黄色葡萄球菌有抗菌活性，MIC 值为 15.6 μg/mL。
T70955	Vinaxanthone SM-345431	Phospholipase; Antibacterial	Metabolism; Microbiology/Virology
	Vinaxanthone (SM-345431) 是一种从青霉菌中提取的小分子化合物，是一种具有选择性和有效性的 semaphorin3A、phospholipase C (PLC) 和 FabI 抑制剂，抑制semaphorin3A 和 FabI。Vinaxanthone 具有抗菌活性，阻止细胞内脂肪酸合成，抑制金黄色葡萄球菌的生长。
TN3861	Dihydropinosylvin 山药	Anti-infection	Microbiology/Virology
	Dihydropinosylvin 是一种植物抗毒素，对枝孢枝孢菌、Botryodiplodia theobromae、黑曲霉和石化青霉具有抗真菌活性，对蜡状芽孢杆菌、金黄色葡萄球菌、铜绿假单胞菌和大肠杆菌也有很强的抗菌活性。双色高粱幼苗的种子和根伸长。
T2S1792	Lycobetaine 石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐	Antibacterial	Microbiology/Virology
	Lycobetaine (Ungeremine) 是一种潜在的抗罗克福尔青霉和黑曲霉的生物杀菌剂。它对柱状黄杆菌有很强的抗菌活性。它有效地靶向哺乳动物以及细菌I 型和II 型拓扑异构酶。它显示出强烈的乙酰胆碱酯酶抑制活性（IC(50) 值为 0.35 microM）。它具有抗原生动物活性，在体外试验中对Trypanosoma brucei rhodesiense、T. cruzi 表现出良好的活性。
T82955	Asperazine (+)-Asperazine
	Asperazine (Compound 5)，一种Penicillium oxalicum产生的生物碱，在HepG2和CaSki细胞系上展现了适度的活性（IC50>50 μM）。
T73887	Cycloaspeptide A
	Cycloaspeptide A 是从内生真菌Penicillium janczewskii 中分离出来的，具有抗寄生虫活性。
T82448	Eremofortin B
	Eremofortin B是倍半萜类化合物，由Penicillium roqueforti PR毒素（PRT）合成。
T13297	Verruculogen	Others	Others
	Verruculogen is a toxin produced mainly by Penicillium and Aspergillus spp. Verruculogen inhibits Ca2+-activated K+ channels, and is an M phase inhibitor of the mammalian cell cycle.
T81676	NG-012
	NG-012为一种神经生长因子(NGF)增强剂，来源于Penicillium verruculosum F-4542的培养液。该化合物能在大鼠嗜铬细胞瘤细胞系(PC12)中提升NGF引导的神经突生长效应。
TN3373	Albrassitriol	Others	Others
	Albrassitriol is a natural product from the cultures of the fungus Penicillium sp.
T75459	Canadensolide
	Canadensolide 是一种 Penicillium canadense 的抗真菌代谢产物。
T13629	Cyclo(Ala-Gly)	Others	Others
	Cyclo (Ala-Gly) is a mangrove endophytic fungus, a metabolite of Penicillium thomi, which is cytotoxic to A549, HepG2 and HT29 cells. The IC50 value is in the range of 9.5-18.1 μM.
T13608	Chaetoglobosin A	Others	Others
	Chaetoglobosin A, the active compound extracted of Penicillium aquamarinium, is a member of the cytochalasan family. It preferentially induces apoptosis.
T73914	Eremofortin A
	Eremofortin A 是一种代谢产物，可以从罗氏青霉的培养物中分离出来。
T71750	Quinolactacin A1
	Quinolactacin A1 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂，可从Penicillium citrinum 中得到。Quinolactacin A1 可用于阿尔茨海默病的研究。
T31134	Cyclochlorotine CCRIS 1316
	Cyclochlorotine is a mycotoxin produced by Penicillium insularum, which can cause liver injury and has carcinogenic properties.
T25211	CC 1014 CC1014,CC-1014,NSC-356885,NSC356885,NSC 356885
	CC 1014 is a polypeptide antibiotic isolated from Penicillium lilacinum that inhibits phosphorylation of ADP, Mg ATPase.
T82210	Herqueilenone A
	Herqueilenone A，一种苯醌-色满酮类化合物，源自夏威夷火山土壤中的真菌Penicillium herquei FT729。
T28379	PF-1163B PF1163B,(-)-PF1163B,PF 1163B
	PF-1163B is an antifungal agent form Penicillium sp. II. PF-1163B inhibits ergosterol (ERG) synthesis with IC50 value of 34 ng/ml. PF-1163B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotox
T12373	Paxilline	Others	Others
	Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline possesses significant anticonvulsant activity.
T13618	Citreoviridin	Others	Others
	Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na+/K+-ATPase whereas, in microsomes, both Na+/K+-ATPase and Mg2+-ATPase activities are significantly stimulated in a dose-dependent manner.
T13872	Roquefortine C	Others	Others
	Roquefortine C is a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins
T38338	Quinolactacin A
	Quinolactactin A is a quinolone fungal metabolite originally isolated from Penicillium. It inhibits TNF production induced by LPS in murine peritoneal macrophages (IC50 = 12.2 μg/ml). It is not active against a variety of bacteria, fungi, and yeasts. Quinolactacin A is a mixture of quinolactacin A1 and A2.
T38033	Benzomalvin B
	Benzomalvin B is a fungal metabolite originally isolated from Penicillium. It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P by 24% in vitro when used at a concentration of 100 μg/ml.
T16035	Meleagrin	Others	Others
	Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast malignancies. It exhibits antimicrobial and anti-proliferative activities.
T13815	Penicillic acid	Apoptosis; Caspase; Antibacterial; Antibiotic	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Penicillic acid，一种由多种Aspergillus和Penicillium物种合成的polyketide mycotoxin，通过阻碍caspase-8的自我处理作用，抑制Fas ligand引发的apoptosis。此外，体外研究表明，Penicillic acid在rat alveolar macrophages中显示出cytotoxic特性。
T83475	1,3,5,6-Tetrahydroxy-8-methylxanthone
	1,3,5,6-四羟基-8-甲基黄酮 (compound 8) 是从海洋真菌青霉属中分离的一种二聚1,4-苯醌衍生物。
T36931	Penicillide
	Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 μM). It is also an antagonist of oxytocin receptors (IC50 = 67 μM). Penicillide inhibits RNA synthesis in P388 murine leukemia cells.
T36438	Sporogen-AO 1
	Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(...
T37690	Phenylpyropene A
	Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 \|1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ...
T38108	Fulvic Acid	Antioxidant; PDE	Metabolism; oxidation-reduction
	Fulvic Acid 是一种来自土壤、沉积物或水生环境中微生物产生的腐殖质的天然产物，是一种首次青霉菌中分离出的酚酸和真菌代谢产物。Fulvic Acid 抑制淀粉样蛋白b (17-42) (AB17-42)二聚化，破坏预先形成的AB17-42三聚体，并结合到磷酸二酯酶5A (PDE5A)的催化位点，可以调节机体免疫系统，影响细胞的氧化状态，改善胃肠功能。Fulvic Acid 可作为氧化剂或还原剂，具有研究糖尿病等慢性炎症性疾病的潜力。
T35761	Carviolin
	Carviolin is an anthraquinone fungal metabolite that has been found inZ. longicaudatawith immunosuppressive and antitrypanosomal activities.1,2It inhibits LPS- or concanavalin A-induced proliferation of mouse splenocytes (IC50s = 4 and 4.5 μg/ml, respectively).1Carviolin is active againstT. b. brucei(MIC = 41.66 μM).2 1.Fujimoto, H., Nakamura, E., Okuyama, E., et al.Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory...

天然产物

Diallyl Trisulfide

Cat.No: T8693

Synonym: 二烯丙基三硫化物,二烯丙基三硫醚

Target: Apoptosis, Reactive Oxygen Species, Antifungal

Cat.No: T3936

Synonym: Expansin,Claviform,散毒素,Clavacin,棒曲霉素

Target: Apoptosis, Others, Antibacterial, Antibiotic, Autophagy

Lycobetaine acetate

Cat.No: T8335

Synonym: 氧化石蒜碱乙酸盐,Oxylycorine

Target: Others

Cat.No: T13305

Target: Anti-infection, Antifungal

Cat.No: T70955

Synonym: SM-345431

Target: Phospholipase, Antibacterial

Dihydropinosylvin

Cat.No: TN3861

Synonym: 山药

Target: Anti-infection

Cat.No: T2S1792

Synonym: 石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐

Target: Antibacterial

Cat.No: T82955

Synonym: (+)-Asperazine

Cycloaspeptide A

Cat.No: T73887

Cat.No: T82448

Cat.No: T13297

Target: Others

Cat.No: T81676

Cat.No: TN3373

Target: Others

Cat.No: T75459

Cat.No: T13629

Target: Others

Chaetoglobosin A

Cat.No: T13608

Target: Others

Cat.No: T73914

Quinolactacin A1

Cat.No: T71750

Cyclochlorotine

Cat.No: T31134

Synonym: CCRIS 1316

Cat.No: T25211

Synonym: CC1014,CC-1014,NSC-356885,NSC356885,NSC 356885

Herqueilenone A

Cat.No: T82210

Cat.No: T28379

Synonym: PF1163B,(-)-PF1163B,PF 1163B

Cat.No: T12373

Target: Others

Cat.No: T13618

Target: Others

Cat.No: T13872

Target: Others

Quinolactacin A

Cat.No: T38338

Cat.No: T38033

Cat.No: T16035

Target: Others

Penicillic acid

Cat.No: T13815

Target: Apoptosis, Caspase, Antibacterial, Antibiotic

1,3,5,6-Tetrahydroxy-8-methylxanthone

Cat.No: T83475

Cat.No: T36931

Cat.No: T36438

Phenylpyropene A

Cat.No: T37690

Cat.No: T38108

Target: Antioxidant, PDE

Cat.No: T35761

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