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Targets Recommended: Apoptosis PD-1/PD-L1

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T3655	BMS-1 PD1-PDL1 inhibitor 1,PD-1/PD-L1 inhibitor 1	Apoptosis; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-1 (PD-1/PD-L1 inhibitor 1)是一种 PD-1/PD-L1蛋白质/蛋白质相互作用的抑制剂，IC50为 6 到 100 nM。
T3146	BMS-202 PD1-PDL1 inhibitor 2,PD-1/PD-L1 inhibitor 2	Apoptosis; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-202 (PD1-PDL1 inhibitor 2) 是一种非肽类 PD-1/PD-L 复合物抑制剂，其 IC50为 18 nM，KD 为 8 μM。它与 PD-L1 直接结合并阻断人类 PD-1/PD-L 的相互作用，具有抗肿瘤活性。
T12387	PD1-PDL1-IN 1	Others	Others
	PD1-PDL1-IN 1 is a potent inhibitor of programmed cell death 1 (PD-1),and used as immune modulator.
T9359	PDL-1 cpd 10	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PDL-1 cpd 10 是一种新型小分子 PD-L1 抑制剂。
T73630	PD1-PDL1-IN 1 TFA
	PD1-PDL1-IN 1 TFA（compound 16）是一种高效的程序性细胞死亡1（PD-1）抑制剂，具有免疫调节作用。
T39588	Human PD-L1 inhibitor IV Human PD-L1 inhibitor IV
	Human PD-L1 inhibitor IV is a polypeptide compound that competitively inhibits the human PD-1 protein. It has a Kd value of 1.38 μM and effectively blocks the interaction between hPD-1 and hPD-L1.
T39589	Human PD-L1 inhibitor III Human PD-L1 inhibitor III
	Human PD-L1 inhibitor III is a human PD-L1 inhibitor.
T39591	Human PD-L1 inhibitor I Human PD-L1 inhibitor I
	Human PD-L1 inhibitor I is a peptide ligand that specifically inhibits the interaction between human PD-L1 and human PD-1. It exhibits a KD value of 3.39 μM, indicating its binding affinity. The presence of Human PD-L1 inhibitor I disrupts the binding between human PD-L1 and human PD-1, thereby attenuating their respective functions.
T39590	Human PD-L1 inhibitor II Human PD-L1 inhibitor II
	Human PD-L1 inhibitor II is a potent PD-L1 inhibitor with anti-cancer activity.
T21737L	PD-1/PD-L1 Inhibitor 3 acetate (1629654-95-0 Free base)
	PD-1/PD-L1 Inhibitor 3 acetate (1629654-95-0 Free base) 抑制人 PD-1 与 PD-L1 的结合，IC50 为 9 nM。
T40112	PROTAC PD-1/PD-L1 degrader-1 PROTAC PD-1/PD-L1 degrader-1
	PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppressed immune response in a co-culture model consisting of Hep3B/OS-8/hPD-L1 cells and CD3 T cells. Additionally, this compound moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
T12379	PD-1-IN-22	Others; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Others
	PD-1-IN-22 是一种有效的程序性细胞死亡 1 (PD-1)/程序性细胞死亡配体1 (PD-L1) 相互作用的抑制剂，IC50 为 92.3 nM。
T82613	Danburstotug STI-3031,IMC-001	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Danburstotug (IMC-001) 是一种对CD274（程序性细胞死亡 1 配体1、PDL1、B7 同源物 1、B7-H1）具有亲和力的IgG1-lambda人源化单克隆抗体。该抗体不仅能够促进免疫应答，还显示出对抗肿瘤的潜力。
T77189	Sudubrilimab
	Sudubrilimab (HS636) 是一种针对 PDL1的 Ig G1-kappa 单克隆抗体。Sudubrilimab 在重链的 C 末端与 TGF-β1受体 Ⅱ 胞外域 (TGFBR2-ECD) 融合，可在免疫抑制性肿瘤微环境中隔离 PD-1/PD-L1通路和 TGF-β 生物活性。

化合物

BMS-1

Cat.No: T3655

Synonym: PD1-PDL1 inhibitor 1,PD-1/PD-L1 inhibitor 1

Target: Apoptosis, PD-1/PD-L1

BMS-202

Cat.No: T3146

Synonym: PD1-PDL1 inhibitor 2,PD-1/PD-L1 inhibitor 2

Target: Apoptosis, PD-1/PD-L1

Target: PD-1/PD-L1

Human PD-L1 inhibitor IV

Cat.No: T39588

Synonym: Human PD-L1 inhibitor IV

Target:

Human PD-L1 inhibitor III

Cat.No: T39589

Synonym: Human PD-L1 inhibitor III

Target:

Human PD-L1 inhibitor I

Cat.No: T39591

Synonym: Human PD-L1 inhibitor I

Target:

Human PD-L1 inhibitor II

Cat.No: T39590

Synonym: Human PD-L1 inhibitor II

Target:

PD-1/PD-L1 Inhibitor 3 acetate (1629654-95-0 Free base)

Cat.No: T21737L

Synonym:

Target:

PROTAC PD-1/PD-L1 degrader-1

Cat.No: T40112

Synonym: PROTAC PD-1/PD-L1 degrader-1

Target: Others, PD-1/PD-L1

Danburstotug

Cat.No: T82613

Synonym: STI-3031,IMC-001

Target: PD-1/PD-L1

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01155	PD-L1 Protein, Mouse, Recombinant (His) Pdcd1l1,CD274 molecule,B7h1,A5300...	Mouse	HEK293 Cells
	PD-L1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is Q3U472.
TMPY-04949	PD-L1 Protein, Human, Recombinant (His), Biotinylated PDCD1LG1,B7H1,PD-L1,B7-H...	Human	HEK293 Cells
	PD-L1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is Q9NZQ7-1.
TMPY-04343	PD-L1 Protein, Human, Recombinant (His) PDL1,B7-H,B7H1,PDCD1LG	Human	HEK293 Cells
	PD-L1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is Q9NZQ7-1.
TMPY-05208	PD-L1 Protein, Human, Recombinant CD274 molecule,PDCD1L1,PD-L1,...	Human	HEK293 Cells
	PD-L1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.2 kDa and the accession number is Q9NZQ7-1.
TMPY-04344	PD-L1 Protein, Mouse, Recombinant (hFc) B7h1,Pdcd1lg1,CD274 molecule,...	Mouse	HEK293 Cells
	PD-L1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.6 kDa and the accession number is Q3U472.
TMPY-05132	PD-L1 Protein, Mouse, Recombinant (His), Biotinylated Pdl1,Pdcd1lg1,B7h1	Mouse	HEK293 Cells
	PD-L1 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.2 kDa and the accession number is Q3U472.
TMPY-05647	PD-L1 Protein, Mouse, Recombinant (hFc & Avi), Biotinylated Pdl1,B7h1,A530045L16Rik,...	Mouse	HEK293 Cells
	PD-L1 Protein, Mouse, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 53.3 kDa and the accession number is Q3U472.
TMPY-06977	PD-L1 Protein, Mouse, Recombinant (His & Avi), Biotinylated Pdcd1l1,B7h1,Pdl1	Mouse	HEK293 Cells
	PD-L1 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 28.02 kDa and the accession number is NP_068693.1.
TMPY-04648	PD-L1 Protein, Human, Recombinant (mFc) CD274 molecule,B7-H1,PDL1,PDCD	Human	HEK293 Cells
	PD-L1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 51.7 kDa and the accession number is Q9NZQ7-1.
TMPY-05238	PD-L1 Protein, Human, Recombinant (hFc), Biotinylated PDL1,B7H1,PDCD1LG1	Human	HEK293 Cells
	PD-L1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52 kDa and the accession number is Q9NZQ7-1.
TMPY-00676	PD-L1 Protein, Human, Recombinant (hFc) PDCD1LG1,B7-H,PDCD1L1,	Human	HEK293 Cells
	PD-L1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52 kDa and the accession number is Q9NZQ7-1.
TMPY-06276	PD-L1 Protein, Human, Recombinant (His & Avi), Biotinylated PD-L1,PDL1,CD274 molecule,PDCD	Human	HEK293 Cells
	PD-L1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 28.48 kDa and the accession number is Q9NZQ7-1.
TMPK-00662	PD-L1 Protein (Primary Amine Labeling), Cynomolgus/Rhesus macaque, Recombinant (His), Biotinylated PDCD1LG1,B7-H1,B7H1,CD27...	Cynomolgus,Rhesus	HEK293 Cells
	B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1 Protein (Primary Amine Labeling), Cynomolgus/Rhesus macaque, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His t...
TMPK-00182	PD-L1 Protein, Human, Recombinant (aa 19-238, His & Avi), Biotinylated PDL1,PD-L1B7 homolog 1,P...	Human	HEK293 Cells
	B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1 Protein, Human, Recombinant (aa 19-238, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecu...
TMPJ-00183	PD-L1 Protein, Human, Recombinant (Flag) B7-H1,Programmed Cell Death 1 Ligand 1...	Human	HEK293 Cells
	PD-L1 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with C-Flag tag. The predicted molecular weight is 35-40 KDa and the accession number is Q9NZQ7.
TMPJ-00182	PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated B7-H1,PDCD1LG1,PD-L1,PDC...	Human	HEK293 Cells
	PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 70-95 KDa and the accession number is Q9NZQ7.
TMPJ-00637	PD-L1 Protein, Cynomolgus, Recombinant (hFc) B7-H,PD-L1B7 homolog 1,Programmed death li...	Cynomolgus	HEK293 Cells
	PD-L1 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 73 KDa and the accession number is G7PSE7.
TMPJ-00638	PD-L1 Protein, Cynomolgus, Recombinant (His) B7-H,B7-H1,PDL1,PDCD1L	Cynomolgus	HEK293 Cells
	PD-L1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-40 KDa and the accession number is G7PSE7.

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