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Search Results for " ptc "

Targets Recommended: BMI-1 Autophagy

17

抑制剂 & 化合物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2345	PTC-209 PTC209,PTC 209	BMI-1; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	PTC-209 是特定的BMI-1抑制剂，不可逆转地损害结直肠癌起始细胞，在 HEK293T 细胞系中的IC50为 0.5 μM。它有抗骨髓瘤活性并损害肿瘤微环境。
T16680	PTC-028	Apoptosis; BMI-1	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	PTC-028 是一种口服有效的干细胞因子 BMI-1的抑制剂，可下调 BMI-1，诱导 caspase 介导的细胞凋亡。它选择性地抑制癌细胞，可用于治疗卵巢癌。
T6178	PTC-209 hydrobromide PTC-209 HBr	BMI-1; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	PTC-209 hydrobromide (PTC-209 HBr) 是一种特定的BMI-1抑制剂，能不可逆转地损害结直肠癌起始细胞，也可损害肿瘤微环境，有抗骨髓瘤活性。它在 HEK293T 细胞系中的IC50为 0.5 μM。
T12575	Unesbulin PTC596	Apoptosis; BMI-1	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Unesbulin (PTC596) 是一种口服有效和选择性的 B 细胞特异性莫洛尼氏鼠白血病病毒整合位点 1 抑制剂。它在急性髓细胞白血病细胞中可下调 MCL-1 并诱导不依赖 p53 的线粒体凋亡，具有抗白血病作用。
T12574	PTC299 Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate	VEGFR; Dehydrogenase	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) 是一种口服活性的 VEGFA mRNA 翻译抑制剂，可选择性地抑制转录后水平的 VEGF 蛋白合成。它还是二氢乳酸脱氢酶 (DHODH) 的有效抑制剂，可研究血液系统恶性肿瘤。
T28470	PTC-510 TFA salt
	PTC-510 TFA salt inhibits hypoxia-induced VEGF expression.
T24682	PTC725 PTC-725,PTC 725
	PTC725 is a selective HCV 1b replicons inhibitor. It has been shown to target the nonstructural protein 4B.
T1805	Ataluren PTC124	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Ataluren (PTC124) 是一种可口服的 CFTR-G542X 无义等位基因抑制剂。
T71552	ASC-JM-17
	ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. ASC-JM17 ameliorates toxicity of the mutant androgen receptor (AR) responsible for SBMA in cell, fly and mouse models. Knockdown of the Drosophila Nrf1 and Nrf2 ortholog cap ‘n’ collar isoform-C, but not Hsf1, blocks the protective effect of ASC-JM17 on mutant AR-induced eye degeneration in flies.
T81355	PTC258
	PTC258为针对伸长复合体蛋白1基因（ELP1）的特异性口服基因剪接调节剂，能促进ELP1在体外和体内的表达增加，并在小鼠模型中显示出良好的耐受性。
T70942	AM-8508
	AM-8508 is a potent and selective PI3Kδ inhibitor. AM-8508 showed good cellular potency (in vitro pAKT IC50 = 4.6 nM ). AM-8505 xhibited excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibit KLH-specific antibodies in animal models, signifying its potential for the treatment of human inflammatory diseases. PI3Kα and PI3Kβ are ubiquitously expressed and play a role in cell growth, division, and survival.
T78437	PTCDA
	PTCDA，一种有机染料分子兼具有机半导体属性。
T3448	GJ103	Others	Others
	GJ103 是通读化合物 GJ072 的活性类似物。一些 GJ072 类似物（例如，GJ103、GJ106、GJ109 和 GJ111）通过 FCATMpSer1981 和 IRIF 测定一致地证明了它们在所有三种 PTC 中的活性。 GJ103 具有与 RTC13 或 RTC14 相似的通读活性，但比 RTC13 和 RTC14 对 A-T 细胞的耐受性更高。
T34425	RTC13 Read-through compound 13,RTC 13,RTC-13
	RTC13, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.
T34426	RTC14 Read-through compound-14,RTC 14,RTC-14,Read-through compound 14
	RTC14, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.
T70944	Carotegrast methyl HCl
	Carotegrast methyl, also known as AJM300 and PTC-100, is an orally-active small molecule that antagonises the α4 integrin receptor. AJM300 reduces inflammation by blocking leucocyte trafficking. Oral treatment with AJM300 dose-dependently inhibited lymphocyte homing to Peyer's patches and increased the peripheral lymphocyte count in the same dose range. AJM300 dose-dependently prevented the development of experimental colitis in mice.
T61306	SRI-41315
	SRI-41315, a chemical compound, effectively addresses premature termination codons (PTCs) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells. It induces a prolonged pause at stop codons, resulting in the restoration of cystic fibrosis transmembrane conductance regulator (CFTR) expression and function. This compound achieves PTC suppression by reducing the abundance of the termination factor eRF1. Additionally, SRI-41315 synergistically enhances CFTR acti...

化合物

Cat.No: T2345

Synonym: PTC209,PTC 209

Target: BMI-1, Autophagy

Cat.No: T16680

Target: Apoptosis, BMI-1

PTC-209 hydrobromide

Cat.No: T6178

Synonym: PTC-209 HBr

Target: BMI-1, Autophagy

Cat.No: T12575

Synonym: PTC596

Target: Apoptosis, BMI-1

Cat.No: T12574

Synonym: Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate

Target: VEGFR, Dehydrogenase

PTC-510 TFA salt

Cat.No: T28470

Cat.No: T24682

Synonym: PTC-725,PTC 725

Cat.No: T1805

Synonym: PTC124

Target: CFTR, Autophagy

Cat.No: T71552

Cat.No: T81355

Cat.No: T70942

Cat.No: T78437

Cat.No: T3448

Target: Others

Cat.No: T34425

Synonym: Read-through compound 13,RTC 13,RTC-13

Cat.No: T34426

Synonym: Read-through compound-14,RTC 14,RTC-14,Read-through compound 14

Carotegrast methyl HCl

Cat.No: T70944

Cat.No: T61306

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02215	Coagulation factor IX/F9 Protein, Human, Recombinant (His) FIX,PTC,Coagulation factor 9,coagulation factor IX,...	Human	HEK293 Cells
	Coagulation factor IX/F9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50 kDa and the accession number is AAB59620.1.
TMPY-04418	RET Protein, Human, Recombinant (aa 658-1114, His & GST) HSCR1,RET51,CDHR16,RET-ELE1,ret proto-oncogene,MEN2A,PTC...	Human	Baculovirus Insect Cells
	RET Protein, Human, Recombinant (aa 658-1114, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.7 kDa and the accession number is P07949-1.
TMPY-05355	Coagulation factor IX/F9 Protein, Human, Recombinant (hFc) P19,Coagulation factor 9,HEMB,FIX,THPH8,Coagulation factor I...	Human	HEK293 Cells
	Coagulation factor IX/F9 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75.5 kDa and the accession number is P00740-1.
TMPY-02270	RET Protein, Human, Recombinant (His) MTC1,PTC,HSCR1,RET51,ret proto-oncogene,CDHR16,MEN2...	Human	HEK293 Cells
	RET Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.1 kDa and the accession number is P07949-1.
TMPH-01946	PTCH2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	PTCH2 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-01528	IHH Protein, Human, Recombinant (His)	Human	E. coli
	Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).

重组蛋白

Coagulation factor IX/F9 Protein, Human, Recombinant (His)

Cat.No: TMPY-02215

Species: Human

Expression System: HEK293 Cells

RET Protein, Human, Recombinant (aa 658-1114, His & GST)

Cat.No: TMPY-04418

Species: Human

Expression System: Baculovirus Insect Cells

Coagulation factor IX/F9 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05355

Species: Human

Expression System: HEK293 Cells

RET Protein, Human, Recombinant (His)

Cat.No: TMPY-02270

Species: Human

Expression System: HEK293 Cells

PTCH2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01946

Species: Human

Expression System: E. coli

IHH Protein, Human, Recombinant (His)

Cat.No: TMPH-01528

Species: Human

Expression System: E. coli

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