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Search Results for " prp "

Targets Recommended: Others

26

抑制剂 & 化合物

1

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T23450	TCS PrP Inhibitor 13 5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One	Others	Others
	TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) 是一种抗朊病毒剂，可抑制蛋白酶抗性朊病毒蛋白的积累。它诱导神经鞘瘤细胞调亡，在ScN2a 和F3细胞株中均显示IC50值为3 nM。
T34172	PRP-194
	PRP-194, CAS#596085-87-9, has a chemical name 5-chloro-2,3,3-trimethyl-3H-pyrrolo[2,3-b]pyridine, is a useful precursor for chemical synthesis of bioactive molecules and dyes. There is no formal name for this chemical. For the convenience of communication
TP1850	PACAP-Related Peptide (PRP), human
	PACAP-Related Peptide (PRP), human,a 29 amino-acid region of the PACAP precursor protein, is synthesized in quantities sufficient for biological and structural studies.
TP1060	GPRP acetate (67869-62-9 free base) Pefabloc FG,Pefa 6003,GPRP acetate	Others	Others
	GPRP acetate (Pefabloc FG) 是纤维蛋白聚合抑制剂，可抑制纤维蛋白原与血小板膜糖蛋白 Ⅱb/IIIa 复合物(糖蛋白 IIb/IIIa 受体)之间的相互作用。
T12563	PrPSc-IN-1	Others	Others
	PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrPSc, inhibits its accumulation(IC50 of 1.6 μM), with anti-prion activity.
T39269	cPrPMEDAP
	cPrPMEDAP, an intermediate metabolite of GS-9219, acts as a prodrug for the guanine nucleotide analog PMEG, demonstrating antiproliferative activity. It is negatively charged at physiological pH, resulting in poor skin permeability.
T27419	GPRP Gly-Pro-Arg-Pro Acetate,Gly-Pro-Arg-Pro Acetate salt
	Gly-Pro-Arg-Pro Acetate, an inhibitor of fibrinogen aggregation, acts by binding to fibrinopeptide A.
T40363	Poly-D-lysine hydrobromide (MW 30000-70000) Poly-D-lysine HBr (MW 30000-70000)	CaSR	GPCR/G Protein
	Poly-D-lysine hydrobromide (MW 30000-70000)(Poly-D-lysine HBr) 是一种可口服的肽类 CaSR 激动剂，可从朊病毒感染的 SN56 神经母细胞瘤细胞中去除蛋白酶 K 抗性的 PrP。
T8556	Z-Gly-Gly-Arg-AMC TFA (66216-78-2 free base) Z-Gly-Gly-Arg-AMC TFA	Others	Others
	Z-Gly-Gly-Arg-AMC TFA (66216-78-2 free base) 是一种凝血酶特异性荧光底物，用于检测 PRP 和贫血小板血浆 (PPP) 中的凝血酶生成。
T2194	Direct Blue 1 Pontamine sky blue,滂胺天蓝,Chicago Sky Blue 6B	GluR	Neuroscience
	Chicago Sky Blue 6B 是免疫荧光组织化学中背景自体荧光的一种复染料。Direct Blue 1 (Pontamine sky blue) 是第一个能够抑制 Aβ 结合的小分子 PrP 配体，在结构上与谷氨酸盐有关，是一种有效且具有竞争性的 VGLUT 抑制剂，不影响质膜转运体。
T12215	Nexopamil racemate (Rac)-Nexopamil	Calcium Channel; 5-HT Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nexopamil racemate（(Rac)-Nexopamil）是 Nexopamil 的外消旋体。Nexopamil racemate 具有潜在的抗哮喘和抗溃疡活性。
T27605	IND45193 IND-45193,IND 45193
	IND45193, an antiprion agent, acts by reducing PrP(Sc) levels in dividing and stationary-phase cells.
T27314	Fe-TMPyP
	Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.
T81312	Ralzapastotug AB-308
	Ralzapastotug (AB-308)是一种靶向朊病毒蛋白PrPC的106-126氨基酸片段的单克隆抗体。
T27408	Gea 3162 Gea3162,Gea-3162
	Gea 3162 is a potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). GEA 3162 stimulates cGMP production in granulocytes, platelets, and polymorphonuclear leukocytes.
T71851	5-trans-Prostaglandin E2
	5-trans-Prostaglandin E2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator. It also inhibits platelet aggregation in human PRP.
T36428	PACAP-related Peptide (human) (trifluoroacetate salt)	PACAP	GPCR/G Protein
	PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in normal human pancreas and adrenal gland tissue and in some tumors that produce vasoactive intestinal peptide (VIP). PRP (1-29) is secreted by CHO-K1 cells that express human recombinant preproPACAP.
TP1799	Z-Gly-Gly-Arg-AMC
	Z-Gly-Gly-Arg-AMC is a specific fluorogenic substrate utilized for assessing thrombin generation in Platelet-Rich Plasma (PRP) and Platelet-Poor Plasma (PPP), with a particular focus on thrombin activity.
TP1298	Z-Gly-Gly-Arg-AMC acetate
	Z-Gly-Gly-Arg-AMC acetate is a thrombase-specific fluorescent matrix for the detection of thrombin production in PRP and poor platelet plasma (PPP).
T37435	PACAP-related Peptide (rat) (trifluoroacetate salt)	PACAP	GPCR/G Protein
	PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in rat hypothalamus as well as within the nerves of the median eminence, the anterior pituitary, bed nucleus of the stria terminalis, cerebellum, cerebral cortex, and amygdala. PRP is also expressed in vaginal, uterine cervica...
T36774	13,14-dehydro-15-cyclohexyl Carbaprostacyclin
	13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2. It inhibits the ADP-induced aggregation of human platelets with an ED50 of about 40 nM in PRP and 77 nM in washed platelets, which is comparable to the potency of carbaprostacyclin.
T60775	BB 0305179
	BB 0305179 (化合物 59) 抑制疏水结构域缺失的特定 PrP 突变体的毒性，是有效的抗朊病毒剂 (IC50 = 4.7 μM)。
T83807	Rp-Adenosine-5'-O-(1-thiotriphosphate) sodium Rp-ATP-α-S
	Rp-Adenosine-5'-O-(1-thiotriphosphate)（Rp-ATP-α-S）是一种含硫核苷酸衍生物ATP-α-S的异构体，同时也是嘌呤P2Y1受体的激动剂。在表达人类P2Y1受体的HEK293细胞中，Rp-ATP-α-S能增加钙的动员（EC50 = 75 nM）。该化合物与洗涤的人类孤立血小板结合（Ki = 156 nM），抑制由ADP引发的人类富血小板血浆（PRP）的聚集（pA2 = 4.74），并且能够抑制前列腺素E1（PGE1）在人类孤立PRP中引发的cAMP产生（pA2 = 5.26）。同时，Rp-ATP-α-S还能引起用氨基甲酰胆碱预先缩紧的豚鼠结肠条带的松弛（EC50 = 56 nM）。此外，Rp-ATP-α-S已经被用于合成被细菌核糖开关识别的环状二核苷酸。
T73416	BiCAPPA
	BiCAPPA 是一个二价抗朊病毒配体。BiCAPPA 可以减少痒病感染细胞中传染性构象形式的朊病毒蛋白 (PrPSc)，EC50值为 0.32 μM。
T36775	13,14-dihydro Prostaglandin E1 13,14-dihydro Prostaglandin E1
	13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively. 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 value of 40 nM. Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hyb...
T12316	Oral antiplatelet agent 1	Others	Others
	Oral antiplatelet agent 1 is a potent antiplatelet agent with an IC50 of 2.94 μM in vitro.

化合物

TCS PrP Inhibitor 13

Cat.No: T23450

Synonym: 5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One

Target: Others

Cat.No: T34172

PACAP-Related Peptide (PRP), human

Cat.No: TP1850

GPRP acetate (67869-62-9 free base)

Cat.No: TP1060

Synonym: Pefabloc FG,Pefa 6003,GPRP acetate

Target: Others

Cat.No: T12563

Target: Others

Cat.No: T39269

Cat.No: T27419

Synonym: Gly-Pro-Arg-Pro Acetate,Gly-Pro-Arg-Pro Acetate salt

Poly-D-lysine hydrobromide (MW 30000-70000)

Cat.No: T40363

Synonym: Poly-D-lysine HBr (MW 30000-70000)

Target: CaSR

Z-Gly-Gly-Arg-AMC TFA (66216-78-2 free base)

Cat.No: T8556

Synonym: Z-Gly-Gly-Arg-AMC TFA

Target: Others

Cat.No: T2194

Synonym: Pontamine sky blue,滂胺天蓝,Chicago Sky Blue 6B

Target: GluR

Nexopamil racemate

Cat.No: T12215

Synonym: (Rac)-Nexopamil

Target: Calcium Channel, 5-HT Receptor

Cat.No: T27605

Synonym: IND-45193,IND 45193

Cat.No: T27314

Cat.No: T81312

Synonym: AB-308

Cat.No: T27408

Synonym: Gea3162,Gea-3162

5-trans-Prostaglandin E2

Cat.No: T71851

PACAP-related Peptide (human) (trifluoroacetate salt)

Cat.No: T36428

Target: PACAP

Z-Gly-Gly-Arg-AMC

Cat.No: TP1799

Z-Gly-Gly-Arg-AMC acetate

Cat.No: TP1298

PACAP-related Peptide (rat) (trifluoroacetate salt)

Cat.No: T37435

Target: PACAP

13,14-dehydro-15-cyclohexyl Carbaprostacyclin

Cat.No: T36774

Cat.No: T60775

Rp-Adenosine-5'-O-(1-thiotriphosphate) sodium

Cat.No: T83807

Synonym: Rp-ATP-α-S

Cat.No: T73416

13,14-dihydro Prostaglandin E1

Cat.No: T36775

Synonym: 13,14-dihydro Prostaglandin E1

Oral antiplatelet agent 1

Cat.No: T12316

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1270	LPRP-Et-97543 (3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one	Others	Others
	(3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one is a natural product

天然产物

Cat.No: TN1270

Synonym: (3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00775	PRNP/Prion Protein, Mouse, Recombinant (hFc) Major prion protein,PrP,ALTPRP,PRIP,PRNP	Mouse	HEK293 Cells
	Prion protein gene (PRNP) variants determine the susceptibility of humans, sheep and mice to prion diseases, whereas polymorphisms in the open reading frame (ORF) of bovine PRNP seem to be unrelated to the incidence of bovine spongiform encephalopathy (BSE). According to the latest reports, the genetic susceptibility of cattle to BSE is associated with polymorphisms ofthe regulatory region of the PRNP gene and the level ofits expression.
TMPY-03842	PRNP/Prion Protein Protein, Human, Recombinant (hFc) PrPc,GSS,p27-30,ASCR,AltPrP,PRIP,PrP	Human	HEK293 Cells
	Prion protein (PRNP) gene is well known for affecting mammal transmissible spongiform encephalopathies (TSE), and is also reported to regulate phenotypic traits (e.g. growth traits) in healthy ruminants. PRNP is fundamental in the pathogenesis of transmissible spongiform encephalopathies. Generally, PRNP gene is associated with prion diseases, whereas variants of the PRNP gene may also explain some cases of Alzheimer disease (AD) and frontotemporal dementia (FTD) in Caucasian populations.
TMPY-05169	Peroxiredoxin 2 Protein, Mouse, Recombinant (His) Torin,TPx-B,Band-8,peroxiredoxin 2,PRP,AL022839,TR,...	Mouse	Baculovirus Insect Cells
	Peroxiredoxin 2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 24.1 kDa and the accession number is Q61171.
TMPY-02200	Peroxiredoxin 2 Protein, Human, Recombinant (His) PRP,HEL-S-2a,TSA,NKEF-B,TDPX1,PTX1,TPX1,peroxiredox...	Human	Baculovirus Insect Cells
	Peroxiredoxin 2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 24 kDa and the accession number is P32119.
TMPY-00252	PNLIPRP1 Protein, Rat, Recombinant (His) pancreatic lipase-related protein 1	Rat	HEK293 Cells
	PNLIPRP1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52 kDa and the accession number is P54316.
TMPH-00492	PNLIPRP1 Protein, Canine, Recombinant (His & SUMO)	Canine	E. coli
	May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro). PNLIPRP1 Protein, Canine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 65.7 kDa and the accession number is P06857.
TMPY-04768	PRPS2 Protein, Human, Recombinant (His) PRPS2,PRSII,phosphoribosyl pyrophosphate synthetase...	Human	E. coli
	PRPS2, a subset of PRS, is reported to be a potential protein associated with Sertoli-cell only syndrome. PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via the p53/Bcl-2/caspases signaling pathway. The gene for PRS II (PRPS2) is located at a different region of the X chromosome, namely Xpter-a21. The promoter region of the human PRPS2 gene was also GC-rich and contained a TATA-like sequence, four Sp1 binding sites and a homopyrimidine...
TMPY-03808	PNLIPRP1 Protein, Human, Recombinant (His) pancreatic lipase-related protein 1,PLRP1	Human	HEK293 Cells
	PNLIPRP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.4 kDa and the accession number is AAH25784.1.
TMPH-00491	PNLIPRP1 Protein, Canine, Recombinant (His)	Canine	P. pastoris (Yeast)
	May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro). PNLIPRP1 Protein, Canine, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 51.7 kDa and the accession number is P06857.

重组蛋白

PRNP/Prion Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00775

Species: Mouse

Expression System: HEK293 Cells

PRNP/Prion Protein Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03842

Species: Human

Expression System: HEK293 Cells

Peroxiredoxin 2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-05169

Species: Mouse

Expression System: Baculovirus Insect Cells

Peroxiredoxin 2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02200

Species: Human

Expression System: Baculovirus Insect Cells

PNLIPRP1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-00252

Species: Rat

Expression System: HEK293 Cells

PNLIPRP1 Protein, Canine, Recombinant (His & SUMO)

Cat.No: TMPH-00492

Species: Canine

Expression System: E. coli

PRPS2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04768

Species: Human

Expression System: E. coli

PNLIPRP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03808

Species: Human

Expression System: HEK293 Cells

PNLIPRP1 Protein, Canine, Recombinant (His)

Cat.No: TMPH-00491

Species: Canine

Expression System: P. pastoris (Yeast)

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