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Search Results for " prl "

Targets Recommended: Phosphatase Others

11

抑制剂 & 化合物

14

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T22136	PRL-3 Inhibitor I PRL-3 Inhibitor,BR-1	Phosphatase; Others	Metabolism; Others
	PRL-3 Inhibitor I (BR-1) 是 PRL-3 抑制剂，IC50=0.9 μM。它在细胞检测中显示降低侵袭性。
T76596	PRL 3195
	PRL 3195 是一种somatostatin receptor 拮抗剂，对人生长抑素受体 sst5、sst2、sst3、sst1和 sst4的Ki 分别为 6、17、66、1000 和 1000 nM。
T76594	PRL 2915
	PRL 2915 是一种有效的人类生长抑素亚型 2 受体拮抗剂 (hsst2)，其Ki 为 12 nM。
T36404L	PRLX-93936 HCL PRLX-93936 hcl(903499-49-0 Free base)	Ferroptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	PRLX-93936 HCL 是 erastin 的类似物，并显示出与顺铂对非小细胞肺癌 (NSCLC) 细胞的协同作用。
T36404	PRLX-93936
	PRLX-93936 is an analog of erastin that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay). PRLX-93936 (1 μM) also inhibits hypoxia-induced increases in HIF-1α expression in ME-180 cervical cancer cells. It inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells with IC50 values of less than 100 nM...
T27499	GSK-A1	HCV Protease; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	GSK-A1 是 III 型磷脂酰肌醇 4-激酶 PI4KA 选择性抑制剂，pIC50为 8.5-9.8，抑制 PtdIns(4,5)P2 再合成，IC50约为 3 nM。GSK-A1有效降低 PtdIns(4)P 的水平，而对 PtdIns(4,5)P2 没影响。GSK-A1在抗丙型肝炎病毒方面有研究的潜力。
T13146	Thienopyridone	Others	Others
	Thienopyridone is a potent and selective inhibitor of phosphatase of regenerating liver (PRL) phosphatase(IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively), and induces p130Cas cleavage and apoptosis and has anticancer effects.
T25228	CG-707 CG 707
	CG-707 is an inhibitor of PRL-3 that acts by blocking the migration and invasion of metastatic cancer cells.
T81598	Org OD 02-0 10-Ethenyl-19-norprogesterone	p38 MAPK	MAPK
	Org OD 02-0（10-Ethenyl-19-norprogesterone）为mPRα（膜孕酮受体α）特异性激动剂，IC50值为33.9 nM。该化合物能够激活MAPK活性，并且能抑制催乳素（PRL）的分泌。
T80114	FA-Ala-Arg	Endogenous Metabolite	Metabolism
	FA-Ala-Arg是一种携带呋喃丙烯酰基的二肽，它能够分解产生精氨酸，并因此提高精氨酸水平，后者可转化为一氧化氮(NO)。该化合物还可增强MCF-7细胞产生NO的能力，并在催乳素(PRL)处理下提升细胞存活率，其中PRL会调节CPD mRNA的表达。
TP1532	γ-2-MSH (41-58), amide
	Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor. It induces a sustained increase in intracellular free calcium levels ([Ca2+]i) in a subpopulation of pituitary cells. Most of the cells responding to

化合物

PRL-3 Inhibitor I

Cat.No: T22136

Synonym: PRL-3 Inhibitor,BR-1

Target: Phosphatase, Others

Cat.No: T76596

Cat.No: T76594

PRLX-93936 HCL

Cat.No: T36404L

Synonym: PRLX-93936 hcl(903499-49-0 Free base)

Target: Ferroptosis, Reactive Oxygen Species

Cat.No: T36404

Cat.No: T27499

Target: HCV Protease, PI4K

Cat.No: T13146

Target: Others

Cat.No: T25228

Synonym: CG 707

Cat.No: T81598

Synonym: 10-Ethenyl-19-norprogesterone

Target: p38 MAPK

Cat.No: T80114

Target: Endogenous Metabolite

γ-2-MSH (41-58), amide

Cat.No: TP1532

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00738	PRL Protein, Human, Recombinant PRL,Prolactin	Human	E. coli
	PRL Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 25 KDa and the accession number is P01236.
TMPJ-00739	PRL Protein, Sheep, Recombinant (His) PRL,Prolactin	Sheep	HEK293 Cells
	PRL Protein, Sheep, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-30 KDa and the accession number is P01240.
TMPK-00742	PRL-3/PTP4A3 Protein, Human, Recombinant (His) PRL-R,PRLR,PRL3,PTP4A3,PRL	Human	E. coli
	Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PTP4A3 (PRL-3) plays an important role in the tumorigenesis and metastasis of multiple tumors.
TMPK-01132	PRL-1/PTP4A1 Protein, Human, Recombinant (His) PTPCAAX1,PRL1,PRL-1,PTP(CAAXI),PTP4A1	Human	E. coli
	Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PRL-1 (PTP4A1) is a key molecule that activates tyrosine phosphorylation, which is important for cancer progression and metastasis.
TMPJ-00053	PRL-2 Protein, Human, Recombinant (His) HU-PP-1,Protein tyrosine phosphatase type IVA 2,OV-1,PTP4A2,...	Human	E. coli
	PTP4A2, also known as PRL2 or PTPCAAX2, is short for Protein tyrosine phosphatase type IVA 2. This protein exists in cell membrane, cytoplasm,endosome and membrane. PTP4A2 is often farnesylated during post-translational modification. Farnesylation is required for membrane targeting and for interaction with RABGGTB. The unfarnesylated forms are redirected to the nucleus and cytosol. It can stimulate progression from G1 into S phase during mitosis and promotes tumors. It also inhibits geranylgeran...
TMPK-00547	PRLR Protein, Cynomolgus, Recombinant (His) Prolactin R,HPRL,MFAB,PRL-R	Cynomolgus	HEK293 Cells
	Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers. PRLR Protein, Cynomolgus, Recombinant (His) is expressed in HEK...
TMPJ-00347	PRLR Protein, Mouse, Recombinant (His) PRLR,PRL-R,Prolactin receptor,Prolactin R	Mouse	HEK293 Cells
	PRLR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 33-40 KDa and the accession number is Q08501.
TMPJ-00346	PRLR Protein, Mouse, Recombinant (hFc) Prolactin R,Prlr,Prolactin receptor,PRL-R	Mouse	HEK293 Cells
	PRLR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 62-88 KDa and the accession number is Q08501.
TMPK-01375	PRLR Protein, Canine, Recombinant (hFc) PRL-R,Prolactin R,MFAB,HPRL	Canine	HEK293 Cells
	Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers. PRLR Protein, Canine, Recombinant (hFc) is expressed in HEK293 ...
TMPY-04507	PRL-2A1 Protein, Rat, Recombinant (His) Prlpm,prolactin family 2, subfamily a, member 1	Rat	HEK293 Cells
	PRL-2A1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.8 kDa and the accession number is A0A0M5HDY8.
TMPY-02386	PTP4A2 Protein, Human, Recombinant (GST) HNMT-S2,PRL-2,HNMT-S1,protein tyrosine phosphatase ...	Human	E. coli
	PRL-2 (Protein-tyrosine phosphatase of regenerating liver 2), also known as PTP4A2 (Protein tyrosine phosphatase type IVA, member 2), is a member of PTP family and has an important function in controlling cell growth. PRL-2 phosphatases may be multifunctional enzymes with diverse roles in a variety of tissue and cell types. The phosphatase of regenerating liver (PRL) family, comprising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer biomarkers and therapeu...
TMPY-04537	PRL8A4 Protein, Rat, Recombinant (His) Prlph,prolactin family 8, subfamily a, member 4	Rat	HEK293 Cells
	PRL8A4 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.5 kDa and the accession number is P33580.
TMPY-01116	SMR3B Protein, Human, Recombinant (mFc) SMR3B,submaxillary gland androgen regulated protein 3B,P-B,<...	Human	HEK293 Cells
	SMR3B Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 32.2 kDa and the accession number is P02814.
TMPY-03807	SMR3B Protein, Human, Recombinant (His) P-B,PBII,PROL3,SMR3B,submaxillary gland androgen regulated p...	Human	HEK293 Cells
	SMR3B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 7.3 kDa and the accession number is P02814.

重组蛋白

PRL Protein, Human, Recombinant

Cat.No: TMPJ-00738

Species: Human

Expression System: E. coli

PRL Protein, Sheep, Recombinant (His)

Cat.No: TMPJ-00739

Species: Sheep

Expression System: HEK293 Cells

PRL-3/PTP4A3 Protein, Human, Recombinant (His)

Cat.No: TMPK-00742

Species: Human

Expression System: E. coli

PRL-1/PTP4A1 Protein, Human, Recombinant (His)

Cat.No: TMPK-01132

Species: Human

Expression System: E. coli

PRL-2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00053

Species: Human

Expression System: E. coli

PRLR Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00547

Species: Cynomolgus

Expression System: HEK293 Cells

PRLR Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00347

Species: Mouse

Expression System: HEK293 Cells

PRLR Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00346

Species: Mouse

Expression System: HEK293 Cells

PRLR Protein, Canine, Recombinant (hFc)

Cat.No: TMPK-01375

Species: Canine

Expression System: HEK293 Cells

PRL-2A1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04507

Species: Rat

Expression System: HEK293 Cells

PTP4A2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02386

Species: Human

Expression System: E. coli

PRL8A4 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04537

Species: Rat

Expression System: HEK293 Cells

SMR3B Protein, Human, Recombinant (mFc)

Cat.No: TMPY-01116

Species: Human

Expression System: HEK293 Cells

SMR3B Protein, Human, Recombinant (His)

Cat.No: TMPY-03807

Species: Human

Expression System: HEK293 Cells

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