3
1
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21598L |
G3335 Acetate
G3335 Acetate (36099-95-3 free base) |
PPAR | DNA Damage/DNA Repair; Metabolism |
G3335 Acetate 被发现是一种新型 PPARgamma 拮抗剂。 | |||
T5532 |
BMS-687453
|
PPAR | DNA Damage/DNA Repair; Metabolism |
BMS-687453 是一种选择性 PPARα激动剂,对人 PPARα的 EC50和 IC50分别为 10 nM 和 260 nM。它较弱地抑制 PPARγ 的活性,EC50和 IC50值分别为 4100 nM 和大于 15000 nM。 | |||
T70192 |
NC-2100
|
||
NC-2100 is an aperoxisome proliferator-activated receptor-gamma (PPARgamma) activator. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2641 | 15-Methoxypinusolidic acid | ERK; IL Receptor; p38 MAPK; Calcium Channel; NOS; NF-κB; COX; JNK; NMDAR; PPAR | DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dep |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02575 |
PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)
CIMT1,PPARγ,GLM1,PPARgamma,PPARG1,PPARG2,NR1C3,pero... |
Human | Baculovirus Insect Cells |
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proli... | |||
TMPY-01427 |
AACS Protein, Human, Recombinant (His)
SUR-5,acetoacetyl-CoA synthetase,ACSF1 |
Human | Baculovirus Insect Cells |
Acetoacetyl-CoA Synthetase (AACS) is a novel cytosolic ketone body (acetoacetate)-specific ligase. The AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. It had been improved that Acetoacetyl-CoA Synthetase is an essential enzyme for the synthesis of fatty acid and cholesterol from ketone bodies, was found to be highly expressed in mouse adipose tissue, and GC box and C/EBPs motif were crucial for AACS promoter ... |