44
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10
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7767 |
FMoc-Val-Cit-PAB-PNP
|
Others | Others |
Fmoc-Val-Cit-PAB-PNP 是一种可降解的 ADC 连接剂,可用于合成抗体偶联药物。 | |||
T37575 |
GLcNAc1-b-PNP
|
Others | Others |
GLcNAc1-b-PNP 是N-乙酰基-β-氨基葡萄糖酶的发色底物,可用于量化人血清和尿液中N-乙酰基-β-D-氨基葡萄糖酶的活性。 | |||
T18318 | MC-Val-Ala-PAB-PNP | Others | Others |
MC-Val-Ala-PAB-PNP 是一种用于合成抗体偶联药物的 linker,可降解。 | |||
T17692 |
Boc-Val-Cit-PAB-PNP
|
Others | Others |
Boc-Val-Cit-PAB-PNP 是一种可切割的 ADC 接头,用于合成抗体-药物偶联物。 | |||
T41083 |
pNP-ADPr
pNP-ADPr,ADP-ribose-pNP |
||
pNP-ADPr is a colorimetric substrate employed in the first continuous activity assays for Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3). Its utilization facilitates research on poly(ADP-ribose) polymerase (PARP) enzymes. | |||
T78401 |
pNP-ADPr disodium
ADP-ribose-pNP disodium |
||
pNP-ADPr 二钠是一种用于检测Poly(ADP-ribose) glycohydrolase (PARG)和ADP-ribosyl hydrolase 3 (ARH3)活性的比色底物。它也适用于poly(ADP-ribose)polymerase (PARP)酶相关研究。 | |||
T3503 |
MC-Val-Cit-PABC-PNP
Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate,马来酰亚胺基己酰-L-缬氨酸-L-瓜氨酸对氨基苄醇 对硝基苯基碳酸脂 |
Others; AChR | Neuroscience; Others |
MC-Val-Cit-PABC-PNP 是一种组织蛋白酶可裂解的 ADC 肽接头,可用于合成抗体偶联药物。 | |||
T38739 |
Mal-PEG2-Val-Cit-PABA-PNP
Mal-PEG2-Val-Cit-PABA-PNP |
||
Mal-PEG2-Val-Cit-PABA-PNP is a cleavable linker compound employed in the synthesis of antibody-drug conjugates (ADCs). | |||
T19139 |
4-Nitrophenyl α-D-galactopyranoside
PNP-alpha-D-Gal,4-硝基苯-α-D-吡喃半乳糖苷,PNP-α-D-Gal |
Others | Others |
4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) 是 4-硝基苯基 (pNP) 糖吡喃糖苷的人工底物,可用于 α-半乳糖苷酶活性的检测。它用作底物能够显著增加 pNP 的释放量。 | |||
T39765 |
Mal-PEG1-Val-Cit-PAB-PNP
Mal-PEG1-Val-Cit-PAB-PNP |
||
Mal-PEG1-Val-Cit-PAB-PNP is an ADC linker employed in the synthesis of ADCs, enabling cleavage. | |||
T37733 |
AMP-PNP tetralithium
|
||
Non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules. Brady (1985) A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 317 73 PMID:2412134 |Yount et al (1971) Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage. Biochemistry 10 2484 PMID:4326768 |Hehl and Neumcke (1994) KATP channels of mouse skeletal muscle: mechan... | |||
T41022 | β-D-glucuronide-pNP-carbonate | ||
β-D-glucuronide-pNP-carbonate is an ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs). | |||
T38816 |
Fmoc-Val-Ala-PAB-PNP
|
||
Fmoc-Val-Ala-PAB-PNP is a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs). | |||
T18875 |
(Ac)Phe-Lys(Alloc)-PABC-PNP
|
Others | Others |
'(Ac)Phe-Lys(Alloc)-PABC-PNP serves as a valuable cleavable linker in the development of antibody-drug conjugates.' | |||
T18512 |
OPSS-Val-Cit-PAB-PNP
|
Others | Others |
OPSS-Val-Cit-PAB-PNP is a cleavable linker employed in ADC (antibody-drug conjugates) synthesis [1]. | |||
T17690 |
Boc-Val-Ala-PAB-PNP
|
Others | Others |
Boc-Val-Ala-PAB-PNP is an ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1]. This cleavable compound efficiently facilitates the attachment of drugs to antibodies, allowing for targeted delivery and release of therapeutic agents within the body, making it an important component in ADC development. | |||
T17816 | DBCO-Val-Cit-PABC-PNP | Others | Others |
DBCO-Val-Cit-PABC-PNP is a cleavable linker for antibody-drug conjugate (ADC) synthesis[1]. | |||
T17945 |
Fmoc-Ala-Ala-Asn-PABC-PNP
|
Others | Others |
Fmoc-Ala-Ala-Asn-PABC-PNP is a peptide cleavable ADC linker[1]. | |||
T15995 |
Mal-PEG4-Val-Cit-PAB-PNP
|
Others | Others |
Mal-PEG4-Val-Cit-PAB-PNP is a cleavable 4-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T17688 |
Boc-Phe-(Alloc)Lys-PAB-PNP
|
Others | Others |
Boc-Phe-(Alloc)Lys-PAB-PNP serves as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs). | |||
T14436 | Azido-PEG3-Val-Cit-PAB-PNP | Others | Others |
Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker employed for synthesizing antibody-drug conjugates (ADCs)[1]. It also serves as a PEG-based PROTAC linker for the synthesis of PROTACs[2]. | |||
T15953 |
Mal-amido-PEG2-Val-Cit-PAB-PNP
|
Others | Others |
Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable 2-unit polyethylene glycol (PEG) based ADC linker utilized in the construction of antibody-drug conjugates (ADCs)[1]. | |||
T17726 |
Cbz-Phe-(Alloc)Lys-PAB-PNP
|
Others | Others |
Cbz-Phe-(Alloc)Lys-PAB-PNP serves as a cleavable linker in the design of antibody-drug conjugates (ADC). | |||
T17981 |
Fmoc-Phe-Lys(Boc)-PAB-PNP
|
Others | Others |
Fmoc-Phe-Lys(Boc)-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker employed in the synthesis of ADCs. | |||
T17980 |
Fmoc-Phe-Lys(Trt)-PAB-PNP
|
Others | Others |
Fmoc-Phe-Lys(Trt)-PAB-PNP is a cleavable linker for antibody-drug conjugate (ADC) synthesis, specifically designed for use in ADC synthesis. | |||
T31835 |
Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP
|
||
Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP is a peptide reagent for ADC conjugation that possesses a cleavable peptide sequence. The hydrophilic PEG spacer increases solubility in aqueous media. | |||
T17387 |
Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP
|
Others | Others |
Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs), which are innovative therapeutic agents that combine the targeting ability of antibodies with potent cytotoxic drugs. | |||
T81870 |
Mal-VC-PAB-PNP-CDN-A
|
||
Mal-VC-PAB-PNP-CDN-A是一种ADC活性分子与linker偶联物,具有特定的生物化学功能。 | |||
T77868 | Mal-amide-PEG8-Val-Ala-PAB-PNP | ||
Mal-amide-PEG8-Val-Ala-PAB-PNP 是一款可降解的ADC linker,专门用于抗体偶联活性分子(ADC)的合成。 | |||
T77831 | Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP | ||
Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP 是一种ADC linker,具有可降解 (cleavable) 特性,适用于抗体偶联活性分子 (ADC) 的合成。 | |||
T12399 |
Peldesine
BCX 34 |
Nucleoside Antimetabolite/Analog; HIV Protease | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
Peldesine (BCX 34) 是一种有效的、竞争性的、可逆的和口服活性的嘌呤核苷磷酸化酶抑制剂。 Peldesine 抑制 T 细胞增殖,IC50 为 800 nM。 Peldesine 可用于皮肤 T 细胞淋巴瘤、牛皮癣和 HIV 感染的研究。 | |||
T67690 |
pNPG-1
4-Nitrophenyl β-D-glucuronide |
Others | Others |
pNPG-1(4-Nitrophenyl β-D-glucuronide) 是一种葡萄糖醛酸单糖衍生物,是β-葡糖苷酶的显色底物。 | |||
T16554 |
PNPP
|
Others | Others |
PNPP 是用于 ELISA 和常规分光光度测定的碱性和酸性磷酸酶的非蛋白质显色底物。 | |||
T19522 |
PNPG
4-硝基苯-Β-D-吡喃葡萄糖苷,4-Nitrophenyl β-D-glucopyranoside |
Others | Others |
PNPG (4-Nitrophenyl β-D-glucopyranoside) 是一种显色的β-D-葡糖苷酶底物,裂解后会产生黄色溶液。 | |||
T38127 |
pNPS-DHA
|
||
pNPS-DHA is an arylamide derivative of docosahexaenoyl ethanolamide that has anti-allergic activity.1It inhibits degranulation of RBL-2H3 mast cells (IC50= 15 μM).pNPS-DHA (1,000 mg/kg) inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) in mice. 1.Kim, I.-H., Kanayama, Y., Nishiwaki, H., et al.Structure-activity relationships of fish oil derivatives with anti-allergic activity in vitro and in vivoJ. Med. Chem.62(21)9576-9592(2019) | |||
TP1847 |
GLGPNPCRKKCYKRDFLGR
|
||
GLGPNPCRKKCYKRDFLGR is a synthetic peptide. | |||
T67822L |
Ulodesine
BCX4208 |
Endogenous Metabolite | Metabolism |
Ulodesine (BCX4208) 是一种嘌呤核苷磷酸化酶 (PNP) 抑制剂,对 PNP 有抑制作用,IC50 值为 2.293 nM/L。Ulodesine 可用于研究高尿酸血症。 | |||
T15337 |
Forodesine
呋咯地辛,BCX-1777,Immucillin-H |
Others | Others |
Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine is an orally active inhibitor of purine nucleoside phosphorylase (IC50s: 0.48 to 1.57 nM for human, mouse, rat, monkey, and dog PNP). It could induce apoptosis in leukemic cells b | |||
T9727 |
2'-Fluoro-2'-Deoxyadenosine
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
2′-Deoxy-2′-fluoroadenosine 可用于合成2 ' -脱氧-2 ' -氟修饰的寡核苷酸。它能被大肠杆菌嘌呤核苷磷酸化酶(PNP)有效地分解成毒性物 2-氟腺嘌呤,对表达大肠杆菌 PNP 的肿瘤表现出良好的体内活性。 | |||
T14964 |
CI 972 anhydrous
CI 972 (anhydrous) |
Others | Others |
CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent. | |||
T11313 |
Forodesine hydrochloride
BCX-1777 hydrochloride,Immucillin-H hydrochloride |
Others | Others |
Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP. | |||
T78379 |
9-Deazaguanine
|
Others | Others |
9-Deazaguanine,一种核苷类似物,有效抑制嘌呤核苷磷酸化酶(PNP)。 | |||
T60799 |
Peldesine dihydrochloride
|
||
Peldesine (BCX 34) dihydrochloride 是一种有效的,竞争性,可逆和口服活性的嘌呤核苷磷酸化酶 (PNP) 抑制剂,对人,大鼠和小鼠红细胞 (RBC)PNP 的 IC50分别为 36 nM,5 nM 和 32 nM。Peldesine dihydrochloride 还是一种 T 细胞 (T-cell) 增殖抑制剂,IC50为 800 nM。Peldesine dihydrochloride 可用于皮肤 T 细胞淋巴瘤,牛皮癣和 HIV 感染的研究。 | |||
T73745 |
Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside
|
||
Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside (EPS; pNP-G7) 作为α-淀粉酶的底物,主要应用于测定α-淀粉酶的活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8083 |
Pyridoxal 5'-phosphate monohydrate
Pyridoxal phosphate monohydrate,Pyridoxal 5-phosphate monohydrate,5-磷酸吡哆醛 |
Others | Others |
Pyridoxal 5'-phosphate monohydrate 是维生素 B6的活性形式,也是多种酶的重要辅因子。它是维生素 B6 在细胞内磷酸化过程中重要的辅酶变异体,能够与其他变异体(如 PNP 、 PMP)发生互换。 | |||
T1709 |
2'-Deoxyinosine
Guanine deoxyriboside,Deoxyinosine,2'-脱氧肌苷 |
Others; Endogenous Metabolite | Metabolism; Others |
2'-Deoxyinosine (Guanine deoxyriboside) 具有 抑制人癌细胞株生长的活性,并发现其与嘌呤核苷磷酸化酶缺乏有关。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02279 |
Nucleoside phosphorylase/PNP Protein, Human, Recombinant (His)
PUNP,PRO1837,purine nucleoside phosphorylase,NP |
Human | E. coli |
Purine nucleoside phosphorylase (PNP) is a purine-metabolizing enzyme that catalyzes the reversible phosphorolysis of 6-oxypurine (deoxy)nucleosides to their respective bases and (deoxy)ribose-1-phosphate. It is a key enzyme in the purine salvage pathway of mammalian cells. Purine nucleoside phosphorylase is a transferase that catalyzes the addition of phosphate and removal of a purine base from guanosine and similar nucleosides.PNP defects result in metabolic abnormalities and fatal T cell immu... | |||
TMPJ-00743 |
PPY Protein, Human, Recombinant (His)
Pancreatic prohormone,Pancreatic polypeptide,PNP,PP... |
Human | HEK293 Cells |
PPY belongs to the NPY family and is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia n... | |||
TMPH-00060 |
ApNPV Viral cathepsin Protein (His & Myc)
V-cath,Viral cathepsin,Cysteine proteinase (CP),VCATH |
ApNPV | E. coli |
Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system. ApNPV Viral cathepsin Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.1 kDa and the accession number is Q91CL9. | |||
TMPJ-01351 |
XPNPEP1 Protein, Human, Recombinant (His)
Xaa-Pro Aminopeptidase 1,X-Prolyl Aminopeptidase 1 Soluble,A... |
Human | E. coli |
X-Prolyl Aminopeptidase (XPNPEP1) is a proline-specific metalloaminopeptidase that specifically catalyzes the removal of any unsubstituted N-terminal amino acid that is adjacent to a penultimate proline residue. Because of its specificity toward proline, it has been suggested that X-Prolyl Aminopeptidase is important in the maturation and degradation of peptide hormones, neuropeptides, and tachykinins, as well as in the digestion of otherwise resistant dietary protein fragments, thereby compleme... | |||
TMPK-01149 |
XPNPEP2 Protein, Rat, Recombinant (His)
Xaa-Pro aminopeptidase 2,Xpnpep2,Aminoacylproline a... |
Rat | HEK293 Cells |
Aminopeptidase P2 (XPNPEP2) is a receptor for TMTP1 tumor-homing peptide. However, the biological and clinical significance of Aminopeptidase P2 in human cancers remains unknown. XPNPEP2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 72.05 kDa and the accession number is Q99MA2. | |||
TMPK-00629 |
XPNPEP2 Protein, Mouse, Recombinant (His)
Xpnpep2,Aminoacylproline aminopeptidase,Xaa-Pro ami... |
Mouse | HEK293 Cells |
Aminopeptidase P2 (XPNPEP2) is a receptor for TMTP1 tumor-homing peptide. However, the biological and clinical significance of Aminopeptidase P2 in human cancers remains unknown. XPNPEP2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 72.24 kDa and the accession number is B1AVD1. | |||
TMPY-02120 |
XPNPEP2 Protein, Human, Recombinant (His)
AEACEI,X-prolyl aminopeptidase (aminopeptidase P) 2, membran... |
Human | HEK293 Cells |
Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. XPNPEP2, the X-linked gene that encodes membranous aminopeptidase P (APP), has been reported to associate with APP activity. The membrane aminopeptidase P (XPNPEP2) is largely limited in distribution ... | |||
TMPH-01850 |
PNPLA2 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
PNPLA2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 71.3 kDa and the accession number is Q96AD5. | |||
TMPJ-01350 |
XPNPEP3 Protein, Human, Recombinant (His)
XPNPEP3,X-Pro Aminopeptidase 3,Aminopeptidase P3,AP... |
Human | E. coli |
Probable Xaa-Pro Aminopeptidase 3 (XPNPEP3) is a member of the peptidase M24B family. XPNPEP3 has two isoforms and both are widely expressed. XPNPEP3 is localized in the Mitochondrion. XPNPEP3 catalyzes the release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 which is a disorder with features of nephronophthisis, a cystic kidney disease leading to end-s... | |||
TMPH-02870 |
PDXP Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskel... |