Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36683 |
Vedaprofen
Quadrisol,PM 150,维达洛芬,CERM 10202 |
COX; Antibacterial; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Vedaprofen (PM 150) 抑制 COX-1 并通过抗炎活性减少前列腺素 H2 的合成。 Vedaprofen 是一种大肠杆菌滑动钳抑制剂,IC50 为 222 μM,Ki 为 131 μM。 | |||
T14960 |
Chroman 1
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
Chroman 1 是高效的的ROCK 选择性抑制剂,对 ROCK2 (IC50=1 pM) 的抑制作用强于 ROCK1 (IC50=52 pM) 。它对MRCK 也有抑制作用,IC50为 150 nM。 | |||
T6583 |
MG-101
ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101,钙蛋白酶抑制剂I |
Cysteine Protease; Proteasome | Proteases/Proteasome; Ubiquitination |
MG-101 (Calpain inhibitor I) 是一种有效的半胱氨酸蛋白酶抑制剂,能够抑制钙蛋白酶I (Ki:190 pM),钙蛋白酶II (Ki:220 pM),组织蛋白酶B (Ki:150 pM)和组织蛋白酶L (Ki:500 pM)。 | |||
T10407 |
Gartisertib
ATR inhibitor 2 |
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation (IC50: 8 nM). | |||
T63506 | Chroman 1 dihydrochloride | ||
Chroman 1 dihydrochloride 是选择性的 ROCK 高效抑制剂,对 ROCK2 (IC50: 1 pM) 的作用比 ROCK1 (IC50: 52 pM) 更强,也能够抑制 MRCK 的活性 (IC50: 150 nM)。 |