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406

抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T16437 PC Biotin-PEG3-alkyne

Others Others
PC Biotin-PEG3-alkyne 是一种 ADC 连接剂,可裂解的 3 单元 PEG,还可以用于合成抗体药物共轭物 (ADC)。
T12376 PC945

Opelconazole

Others Others
PC945 (Opelconazole) 是一种有效的广谱抗真菌化合物,对烟曲霉甾醇 14α-去甲基酶 (CYP51A/CYP51B) 有抑制作用,可用于研究肺部真菌感染。
T39446 PC DBCO-PEG4-NHS ester

PC DBCO-PEG4-NHS ester

PC DBCO-PEG4-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T35580 POV-PC

Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-oxovaleroyl)-phosphatidylcholine, or POV-PC, is one of the oxLDL species derived from 2-arachidonoyl or eicosapentanoyl phospholipids. POV-PC conf...
T36172 KOdiA-PC

Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine, or KOdiA-PC, is one of the most potent CD36 ligands among the oxLDL species. KOdiA-PC confers CD36 scave...
T35956 PAz-PC

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were isolated and purified from oxLDL and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. PAz-PC is one of the predominant oxLDL species and may be one of the important structural determinants of oxLDL.
T36171 KDdiA-PC

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. KDdiA-PC is one of the most potent CD36 ligands among the oxLDL species. KDdiA-PC confers CD-36 scavenger receptor binding affinity to LDL at a frequency of only two...
T71252 PC-046

PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory activity in a variety of tumor types in vitro, and efficacy in SCID mice was shown in human tumor xenografts of MV-4-11 acute myeloid leukemia, MM.1S multiple myeloma, and DU-145 prostate cancer. Pharmacokinetic studies demonstrated relatively high oral bioavailability (71 %) with di...
T37580 Arachidonoyl thio-PC

Arachidonoyl Thio-PC is a substrate for many phospholipase A2s (PLA2s) including sPLA2, cPLA2, and iPLA2. Cleavage of the sn-2 fatty acid by PLA2 results in generation of a free thiol which reacts with chromogenic reagents such as DTNB (Ellman's reagent) and DTP to allow quantitation of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by excluding or inhibiting sPLA2 and iPLA2 activities in the assay.
T37123 1,2-Dioctanoyl PC

Phosphatidylcholine (PC) species are a common class of phospholipids that comprise the mammalian cell membrane. 1,2-Dioctanoyl PC is a synthetic analog of natural phosphatidylcholine species containing saturated C8:O fatty acids in the sn-1 and sn-2 positions of the glycerol backbone. It exhibits a critical micelle concentration (CMC) value of 0.25 mM at 27°C. 1,2-Dioctanoyl PC serves as an efficient substrate for phospholipase D (PLD) as well as sPLA2 isozymes from bovine pancreas and bee venom...
T36143 10-Pyrene-PC

10-Pyrene-PC is a substrate for all PLA2s with the exception of cPLA2 and PAF-AH. Upon phospholipid hydrolysis, 10-pyrenyldecanoic acid is produced from 10-pyrene-PC. The monomeric 10-pyrenyldecanoic acid exhibits fluorescence (excitation 345 nm, emission 395 nm), allowing quantitation of phospholipase activity.
T37244 Palmitoyl thio-PC

Thioester analogs of glycerophospholipids, in combination with Ellman's reagent, are convenient colorimetric substrates for the measurement of phospholipase (PL) activity. Palmitoyl thio-PC is a chromogenic PLA2 substrate that contains a palmitoyl thioester at the sn-2 position of the glycerol backbone. Hydrolysis of the thioester by PLA2 yields a free thiol that reacts readily with DTNB (Ellman's reagent) giving a bright yellow product with an absorbance maximum at 412 nm. Palmitoyl thio-PC has...
T40402 24:0 Lyso PC

24:0 Lyso PC, a lysophospholipid (LyP), has potential applications in mRNA drug delivery.
T18524 PC-PEG11-Azide

Others Others
PC-PEG11-Azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T4949 1,2-Didecanoyl-sn-glycero-3-phosphocholi

1,2-Didecanoyl Phosphatidylcholine,1,2-Didecanoyl PC,L-A-癸酰磷脂酰胆碱

Others Others
1,2-Didecanoyl-sn-glycero-3-phosphocholi (1,2-Didecanoyl PC) 是一种合成的、疏水性较低的磷脂,已被发现可用于增强肽类药物和激素(如胰岛素)的吸收。
T16438 PC Biotin-PEG3-azide

Others Others
PC Biotin-PEG3-azide is a cleavable three-unit polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker, employed in the synthesis of ADCs[1].
T18521 PC DBCO-PEG3-biotin

Others Others
PC DBCO-PEG3-biotin is a trimeric polyethylene glycol (PEG) linker, specifically designed for antibody-drug conjugate (ADC) synthesis, with a cleavable moiety consisting of a dibenzocyclooctyne (DBCO) group and a biotin molecule. This linker provides a platform for the efficient attachment of drugs to antibodies, facilitating the targeted delivery and controlled release of therapeutic agents in ADCs[1].
T37043 1,2-Dihexadecyl-sn-glycero-3-PC

1,2-Dihexadecyl-sn-glycero-3-PC 可用于生命科学领域的相关研究。其产品编号为 T37043,CAS号为 36314-47-3。
T37623 1,2-Dierucoyl-sn-glycero-3-PC

1,2-Dierucoyl-sn-glycero-3-PC is a phospholipid containing erucic acid at the sn-1 and sn-2 positions. It has been used in the study of lipid membranes and to determine the effect of long-chain phospholipids on the secondary structure of human islet amyloid polypeptide (hIAPP).
T18518 PC Biotin-PEG3-NHS ester

Others Others
PC Biotin-PEG3-NHS ester is a cleavable ADC linker comprising three PEG units. This linker is specifically designed for use in the synthesis of antibody-drug conjugates (ADCs)[1].
T28777 Silicon Phthalocyanine 4

Pc-4,Pc 4,Pc4

Silicon Phthalocyanine 4 is a drug with anti-cutaneous neoplasms activity.
T18522 PC Mal-NHS carbonate ester

Others Others
PC Mal-NHS carbonate ester is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. This chemical compound plays a crucial role in facilitating the conjugation of drugs to antibodies, enabling targeted delivery and enhanced efficacy of therapeutic agents. Its unique carbonate ester structure allows for efficient cleavage in the targeted environment, ensuring the controlled release of the drug payload. Its application in ADC synthesis highlights its imp...
T18516 PC Alkyne-PEG4-NHS ester

Others Others
PC Alkyne-PEG4-NHS ester is a cleavable 4-unit PEG linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].
T18525 PC SPDP-NHS carbonate ester

Others Others
PC SPDP-NHS carbonate ester is a cleavable linker compound utilized in the synthesis of antibody-drug conjugates (ADCs)[1].
T28305 PC58538

PC-58538,PC 58538

PC58538 is an inhibitor of FtsZ protein, a important role in the division machinery of bacterial cells.
T18519 PC-Biotin-PEG4-NHS carbonate

Others Others
PC-Biotin-PEG4-NHS carbonate is a polyethylene glycol (PEG) derived linker employed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T17586 Biotin-PEG4-PC-PEG4-alkyne

Others Others
Biotin-PEG4-PC-PEG4-alkyne is a polyethylene glycol (PEG)-based proteolysis targeting chimera (PROTAC) linker utilized in the synthesis of PROTACs[1].
T18520 PC-Biotin-PEG4-PEG3-azide

Others Others
PC-Biotin-PEG4-PEG3-azide is a cleavable 7-unit polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker employed for the synthesis of ADCs [1].
T38356 1,2-Dipalmitoyl-13C-sn-glycero-3-PC

1,2-Dipalmitoyl-13C-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC by GC- or LC-MS. 1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.1,2,3,4 It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.3 Incorporation...
T18523 PC Methyltetrazine-PEG4-NHS carbonate ester

Others Others
PC Methyltetrazine-PEG4-NHS carbonate ester is a polyethylene glycol (PEG) derived linker specifically designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].
T126032 PC-M5'

T18517 PC Azido-PEG11-NHS carbonate ester

Others Others
PC Azido-PEG11-NHS carbonate ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].
T37486 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is toxic to human umbilical vein endothelial cells (HUVECs) when used at a concentration of 100 μM.
T81479 Phytochelatin 3

PC 3

Phytochelatin 3 (PC 3)是一种具有金属螯合能力的小型肽,主要用途为螯合重金属离子。
T16081 MIV-150

PC 815

Others Others
MIV-150 is a nonnucleoside inhibitor of reverse transcriptase (NNRT). MIV-150 also blocking HIV-1 and HIV-2 infections (EC50<1 nM against HIV-1/HIV-2MN).
T37485 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC by 15-lipoxygenase (15-LO).
T75000 Mal-Pc

Reactive Oxygen Species Immunology/Inflammation; Metabolism; NF-κB
Mal-Pc为基于酞菁和马来酰亚胺设计的多功能分子光敏剂。它能在癌细胞内与GSH反应,耗减GSH并抑制其聚集,进而增强ROS介导的PDT效果。
T81477 Phytochelatin 4

PC 4

Phytochelatin 4 (PC 4)为植物体内富含Cys的小分子短肽,其结构特征为含有γ-Glu-Cys基序。
T81475 Phytochelatin 5

PC 5

Phytochelatin 5为植物合成的金属结合化合物,具有可能降低如镉等膳食有毒金属的生物利用度。
T81473 Phytochelatin 6

PC 6

Phytochelatin 6是一种植物所产生的金属结合化合物,其可能降低(如镉)等膳食有毒金属的生物利用度。
T34199 Pyrenelecithin

PPDPC,Pyrene-PC,P10PC

Pyrenelecithin is a fluorescent dye used a lipid indicator.
T81478 Phytochelatin 3 TFA

PC 3 TFA

Phytochelatin 3 (PC 3) TFA,一小分子螯合肽,专用于重金属离子螯合。
T81474 Phytochelatin 5 TFA

PC 5 TFA

Phytochelatin 5 TFA为植物合成的金属结合化合物,有潜在降低食物中有毒金属(例如镉)生物可利用性的作用。
T81472 Phytochelatin 6 TFA

PC 6 TFA

Phytochelatin 6 TFA为植物合成的金属结合化合物,具有降低如镉等膳食有毒金属的生物可利用性的潜能。
T41109 Phytochelatin 2 (PC2)

Phytochelatin 2, a short plant peptide, serves as an essential metal-binding compound. Phytochelatins are a diverse group of plant compounds that play a crucial role in chelating metals, safeguarding against metal toxicity, and maintaining metal homeostasis.
T38218 1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 是一种在生物膜中的磷脂,在 sn-1 和 sn-2 位置分别含有硬脂酸和二十二碳六烯酸。它已被用于研究脂膜的组织和动力学。在超氧化物歧化酶 1 突变体转基因小鼠肌萎缩性脊髓侧索硬化症(ALS)模型中1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 的水平在疾病晚期会在 L5 前角下降。1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 可用于研究生物膜。
T81476 Phytochelatin 4 TFA

PC 4 TFA

Phytochelatin 4 (PC 4) TFA,一种在植物中发现的短肽,富含 Cys,且具有 γ-Glu-Cys 基序。
T81404 Prezatide copper

Bisprezatide copper,PC 1020,Iamin

Prezatide Copper(亦称Iamin)具有促进伤口愈合的多重特性,且用于抑制脱发。
T34030 Phosphatidyl choline (from egg yolk)

Azolectin,PC. Phosphatidyl choline,L-α-Lecithin

Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup. They are a major component of biological membranes and can be easily obtained from a variety of readily available sources, such as egg yolk or soybeans, from w
T27710 K6PC-5

K6PC5,K6PC 5

S1P Receptor GPCR/G Protein
K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and virus infection, K6PC-5 presents a promising compound for research purposes.

化合物

PC Biotin-PEG3-alkyne
Cat.No: T16437
Synonym:
Target: Others
PC945
Cat.No: T12376
Synonym: Opelconazole
Target: Others
PC DBCO-PEG4-NHS ester
Cat.No: T39446
Synonym: PC DBCO-PEG4-NHS ester
Target:
POV-PC
Cat.No: T35580
Synonym:
Target:
KOdiA-PC
Cat.No: T36172
Synonym:
Target:
PAz-PC
Cat.No: T35956
Synonym:
Target:
KDdiA-PC
Cat.No: T36171
Synonym:
Target:
PC-046
Cat.No: T71252
Synonym:
Target:
Arachidonoyl thio-PC
Cat.No: T37580
Synonym:
Target:
1,2-Dioctanoyl PC
Cat.No: T37123
Synonym:
Target:
10-Pyrene-PC
Cat.No: T36143
Synonym:
Target:
Palmitoyl thio-PC
Cat.No: T37244
Synonym:
Target:
24:0 Lyso PC
Cat.No: T40402
Synonym:
Target:
PC-PEG11-Azide
Cat.No: T18524
Synonym:
Target: Others
1,2-Didecanoyl-sn-glycero-3-phosphocholi
Cat.No: T4949
Synonym: 1,2-Didecanoyl Phosphatidylcholine,1,2-Didecanoyl PC,L-A-癸酰磷脂酰胆碱
Target: Others
PC Biotin-PEG3-azide
Cat.No: T16438
Synonym:
Target: Others
PC DBCO-PEG3-biotin
Cat.No: T18521
Synonym:
Target: Others
1,2-Dihexadecyl-sn-glycero-3-PC
Cat.No: T37043
Synonym:
Target:
1,2-Dierucoyl-sn-glycero-3-PC
Cat.No: T37623
Synonym:
Target:
PC Biotin-PEG3-NHS ester
Cat.No: T18518
Synonym:
Target: Others
Silicon Phthalocyanine 4
Cat.No: T28777
Synonym: Pc-4,Pc 4,Pc4
Target:
PC Mal-NHS carbonate ester
Cat.No: T18522
Synonym:
Target: Others
PC Alkyne-PEG4-NHS ester
Cat.No: T18516
Synonym:
Target: Others
PC SPDP-NHS carbonate ester
Cat.No: T18525
Synonym:
Target: Others
PC58538
Cat.No: T28305
Synonym: PC-58538,PC 58538
Target:
PC-Biotin-PEG4-NHS carbonate
Cat.No: T18519
Synonym:
Target: Others
Biotin-PEG4-PC-PEG4-alkyne
Cat.No: T17586
Synonym:
Target: Others
PC-Biotin-PEG4-PEG3-azide
Cat.No: T18520
Synonym:
Target: Others
1,2-Dipalmitoyl-13C-sn-glycero-3-PC
Cat.No: T38356
Synonym:
Target:
PC Methyltetrazine-PEG4-NHS carbonate ester
Cat.No: T18523
Synonym:
Target: Others
PC-M5'
Cat.No: T126032
Synonym:
Target:
PC Azido-PEG11-NHS carbonate ester
Cat.No: T18517
Synonym:
Target: Others
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC
Cat.No: T37486
Synonym:
Target:
Phytochelatin 3
Cat.No: T81479
Synonym: PC 3
Target:
MIV-150
Cat.No: T16081
Synonym: PC 815
Target: Others
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC
Cat.No: T37485
Synonym:
Target:
Mal-Pc
Cat.No: T75000
Synonym:
Target: Reactive Oxygen Species
Phytochelatin 4
Cat.No: T81477
Synonym: PC 4
Target:
Phytochelatin 5
Cat.No: T81475
Synonym: PC 5
Target:
Phytochelatin 6
Cat.No: T81473
Synonym: PC 6
Target:
Pyrenelecithin
Cat.No: T34199
Synonym: PPDPC,Pyrene-PC,P10PC
Target:
Phytochelatin 3 TFA
Cat.No: T81478
Synonym: PC 3 TFA
Target:
Phytochelatin 5 TFA
Cat.No: T81474
Synonym: PC 5 TFA
Target:
Phytochelatin 6 TFA
Cat.No: T81472
Synonym: PC 6 TFA
Target:
Phytochelatin 2 (PC2)
Cat.No: T41109
Synonym:
Target:
1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
Cat.No: T38218
Synonym:
Target:
Phytochelatin 4 TFA
Cat.No: T81476
Synonym: PC 4 TFA
Target:
Prezatide copper
Cat.No: T81404
Synonym: Bisprezatide copper,PC 1020,Iamin
Target:
Phosphatidyl choline (from egg yolk)
Cat.No: T34030
Synonym: Azolectin,PC. Phosphatidyl choline,L-α-Lecithin
Target:
K6PC-5
Cat.No: T27710
Synonym: K6PC5,K6PC 5
Target: S1P Receptor
Cat. No. Product Name Target Signaling Pathways
T19224 C-Phycocyanin

C-PC,藻蓝蛋白,C-藻蓝蛋白

Others Others
C-Phycocyanin (C-PC) 是一种蛋白质色素,常作为人类的优良营养补充剂。
T19085 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC

POPC,2-油酰-1-棕榈锡甘油-3-磷酸胆碱,1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine,Palmitoyloleoylphosphatidylcholine

Others Others
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Palmitoyloleoylphosphatidylcholine) 是生物膜的主要成分,是一种磷脂。它用于脂质体的制备以及脂质双层的特性的研究。
T9510 1,2-Distearoyl-sn-glycero-3-phosphorylcholine

DSPC,L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL,1,2-Distearoyl-sn-glycero-3-PC,二硬脂酰磷脂酰胆碱

Others Others
1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) 是一种脂质纳米颗粒(LNP) 系统中的脂质成分,可用于合成脂质体。
T74236 1-Oleoyl-2-palmitoyl-sn-glycero-3-PC

1-Oleoyl-2-palmitoyl-sn-glycero-3-PC,由油酸衍生,用于脂质体合成。
T36791 Lysophosphatidylcholine 18:2

1-Linoleoyl-2-hydroxy-sn-glycero-3-PC (LGPC) is a lysophospholipid containing linoleic acid at thesn-1 position that has been found in mouse heart, lung, liver, spleen, kidney, plasma, and serum.1Serum levels of LGPC decrease with increasing insulin resistance and dysglycemia in humans.2 1.Okudaira, M., Inoue, A., Shuto, A., et al.Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MSJ. Lipid Res.55(10)2178-2192(2014) 2.Gall, ...
TQ0275 LysoPC(14:0/0:0)

Others; Endogenous Metabolite Metabolism; Others
LysoPC(14:0/0:0) 是一种溶血磷脂,它是单甘油磷脂,其中甘油取代位点被磷酸胆碱占据。LysoPC(14:0/0:0) 有抗痉挛作用。
T16442 PCO371

2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-

Thyroid hormone receptor(THR) Endocrinology/Hormones
PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) 是口服具有活性的甲状旁腺激素受体 1 的完全激动剂,对 PTHR2 无作用
T7773 DPPC

1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOL,二棕榈酸磷脂酰胆碱,129Y83

Endogenous Metabolite Metabolism
DPPC (129Y83) 是一种磷酸甘油酯,能够用于制备脂质体单层。DPPC-脂质体能够用作小鼠中诱导针对 GSL 抗原的免疫应答的递送载体。
T4850 PCL 016

2-吡啶甲酸,2-Picolinic acid

Virus Protease; Endogenous Metabolite Metabolism; Microbiology/Virology
PCL 016 (2-Picolinic acid) 是一种局部抗病毒剂,可抑制兔体内的腺病毒复制。
T75545 PCSK9-IN-9

PCSK9-IN-9 是一种天然来源的异香豆素。PCSK9-IN-9 可抑制原蛋白转化酶枯草菌素 kexin 型 9 (PCSK9)、IDOL 和 SREBP2的 mRNA 表达水平。PCSK9-IN-9 抑制 PCSK9的 IC50为 11.9 μM。
T5288 Cytidine-5'-triphosphate disodium

胞苷 5'-三磷酸二钠盐,CTP,Cytidine 5'-triphosphate (disodium salt)

Others; Endogenous Metabolite Metabolism; Others
Cytidine-5'-triphosphate disodium (CTP) 是内源性代谢产物的一种。
T3874 Diosgenin glucoside

延龄草苷,地索苷,Disogluside,Trillin

Apoptosis; Others; Autophagy Apoptosis; Autophagy; Others
Diosgenin glucoside (Trillin) 是一种来自蒺藜的皂苷元类天然产物,可通过调节自噬和减轻细胞凋亡来保护脊髓免受损伤。它通过调节小胶质细胞 M1 极化提供神经保护,和其他具有类似活性的合成糖苷可用于治疗高胆固醇血症和动脉粥样硬化。
T4S2126 Ginkgetin

银杏双黄酮,银杏素

Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
Ginkgetin 是从银杏叶中分离得到的一种双黄酮,具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂,IC50值为 5.92 μM。
TN1872 Linderone

Others Others
Linderone A shows anticancer activity against A549 non-small cell lung cancer cells and PC-3 prostate adenocarcinoma cell line.
TN3465 Atalantoflavone

Antifection Microbiology/Virology
Atalantoflavone shows urease inhibitory potential. It displays weak cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3.
TN2273 Tigloylgomisin P

巴豆酰戈米辛 P,巴豆酰戈米辛P

Others Others
Tigloylgomisin P shows moderate to marginal cytotoxicity against A549, PC-3, KB and KBvin human cancer cell lines.
TN3737 Cycloartane-3,24,25-triol

ATPase Membrane transporter/Ion channel
Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
TN4352 Jatamanvaltrate B

Others Others
Jatamanvaltrate B shows cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8),and hepatoma (Bel7402) cell lines.
T81529 Peganumine A

Peganumine A,一种天然产物,源自Peganum harmala,具备对HL-60、MCF-7、PC-3、HepG2细胞线显示出细胞毒性作用,其IC50值依次为5.8、38.5、40.2、55.4 µM[1]< /sup>。
T83471 10-Deacetyl-13-oxobaccatin III

10-Deacetyl-13-oxobaccatin III是一款从Taxus sumatrana分离的紫杉烷。在30 μg/mL的浓度下,对A498、NCI-H226、A549、PC-3细胞系展现细胞毒性作用,其抑制率分别达到29.7%、49.2%、43.9%、65.3%。
TN3646 Chlorovaltrate K

Others Others
Chlorovaltrate K shows moderate cytotoxicity against lung adenocarcinoma (A 549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8) and hepatoma (Bel 7402) cell lines with IC50 values of 0.89-9.76 uM.
TN5249 Volvaltrate B

Others Others
Volvaltrate B shows cytotoxic activity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines, with IC50 values of 8.5, 2.0, 3.2, and 6.1 uM, respectively.
TN5655 Broussonin B

Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin B can induce neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, and show moderate inhibitory activities against a chymotrypsin-like activity of the proteasome.B
TN6394 Alisol B acetate

Alisol B acetate can induce Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to the apoptotic effect. Alisol B aceta
TN3125 5-Methoxycanthin-6-one

Others Others
5-Methoxycanthin-6-one displays moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC50 values ranging from 13.5-15.4 uM versus doxorubicine with IC50 = 1.5 uM. It also exhibits a clear suppressive effect on the phagocytosi
TN5682 2,6,4'-Trihydroxy-4-methoxybenzophenone

2,6,4'-Trihydroxy-4-methoxybenzophenone shows weak inhibitory activity of testosterone 5alpha-reductase, it also shows significant inhibition of pancreatic lipase activity. 2,6,4'-Trihydroxy-4-methoxybenzophenone has neurotrophic activity, it induced neurite outgrowth in PC-12 cells at concentration of 50 microg/ml. 2,6,4′-Trihydroxy-4-methoxybenzophenone exhibits low cytotoxic effect against HeLa and 3T3 cell lines with IC50 values of 132 ug/ml and 158 ug/ml, repectively. It also shows antiox...
T36845 Isogarcinol

Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental auto...

天然产物

C-Phycocyanin
Cat.No: T19224
Synonym: C-PC,藻蓝蛋白,C-藻蓝蛋白
Target: Others
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC
Cat.No: T19085
Synonym: POPC,2-油酰-1-棕榈锡甘油-3-磷酸胆碱,1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine,Palmitoyloleoylphosphatidylcholine
Target: Others
1,2-Distearoyl-sn-glycero-3-phosphorylcholine
Cat.No: T9510
Synonym: DSPC,L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL,1,2-Distearoyl-sn-glycero-3-PC,二硬脂酰磷脂酰胆碱
Target: Others
1-Oleoyl-2-palmitoyl-sn-glycero-3-PC
Cat.No: T74236
Synonym:
Target:
Lysophosphatidylcholine 18:2
Cat.No: T36791
Synonym:
Target:
LysoPC(14:0/0:0)
Cat.No: TQ0275
Synonym:
Target: Others, Endogenous Metabolite
PCO371
Cat.No: T16442
Synonym: 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-
Target: Thyroid hormone receptor(THR)
DPPC
Cat.No: T7773
Synonym: 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOL,二棕榈酸磷脂酰胆碱,129Y83
Target: Endogenous Metabolite
PCL 016
Cat.No: T4850
Synonym: 2-吡啶甲酸,2-Picolinic acid
Target: Virus Protease, Endogenous Metabolite
PCSK9-IN-9
Cat.No: T75545
Synonym:
Target:
Cytidine-5'-triphosphate disodium
Cat.No: T5288
Synonym: 胞苷 5'-三磷酸二钠盐,CTP,Cytidine 5'-triphosphate (disodium salt)
Target: Others, Endogenous Metabolite
Diosgenin glucoside
Cat.No: T3874
Synonym: 延龄草苷,地索苷,Disogluside,Trillin
Target: Apoptosis, Others, Autophagy
Ginkgetin
Cat.No: T4S2126
Synonym: 银杏双黄酮,银杏素
Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy
Linderone
Cat.No: TN1872
Synonym:
Target: Others
Atalantoflavone
Cat.No: TN3465
Synonym:
Target: Antifection
Tigloylgomisin P
Cat.No: TN2273
Synonym: 巴豆酰戈米辛 P,巴豆酰戈米辛P
Target: Others
Cycloartane-3,24,25-triol
Cat.No: TN3737
Synonym:
Target: ATPase
Jatamanvaltrate B
Cat.No: TN4352
Synonym:
Target: Others
Peganumine A
Cat.No: T81529
Synonym:
Target:
10-Deacetyl-13-oxobaccatin III
Cat.No: T83471
Synonym:
Target:
Chlorovaltrate K
Cat.No: TN3646
Synonym:
Target: Others
Volvaltrate B
Cat.No: TN5249
Synonym:
Target: Others
Broussonin B
Cat.No: TN5655
Synonym:
Target:
Alisol B acetate
Cat.No: TN6394
Synonym:
Target:
5-Methoxycanthin-6-one
Cat.No: TN3125
Synonym:
Target: Others
2,6,4'-Trihydroxy-4-methoxybenzophenone
Cat.No: TN5682
Synonym:
Target:
Isogarcinol
Cat.No: T36845
Synonym:
Target:
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