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Cat. No. | Product Name | Target | Signaling Pathways |
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T27710 |
K6PC-5
K6PC5,K6PC 5 |
S1P Receptor | GPCR/G Protein |
K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and virus infection, K6PC-5 presents a promising compound for research purposes. | |||
T81475 |
Phytochelatin 5
PC 5 |
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Phytochelatin 5为植物合成的金属结合化合物,具有可能降低如镉等膳食有毒金属的生物利用度。 | |||
T81474 |
Phytochelatin 5 TFA
PC 5 TFA |
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Phytochelatin 5 TFA为植物合成的金属结合化合物,有潜在降低食物中有毒金属(例如镉)生物可利用性的作用。 | |||
T126032 |
PC-M5'
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T35580 |
POV-PC
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Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-oxovaleroyl)-phosphatidylcholine, or POV-PC, is one of the oxLDL species derived from 2-arachidonoyl or eicosapentanoyl phospholipids. POV-PC conf... | |||
T36172 |
KOdiA-PC
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Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine, or KOdiA-PC, is one of the most potent CD36 ligands among the oxLDL species. KOdiA-PC confers CD36 scave... | |||
T78810 |
BWA-522
|
Androgen Receptor | Endocrinology/Hormones |
BWA-522是一种口服有效的小分子PROTACs,针对AR-FL和AR-V7显示出显著的降解活性。该化合物通过对Androgen Receptor的AR-NTD进行拮抗,诱发PC细胞的apoptosis。在LNCaP异种移植模型中,BWA-522以每日60 mg/kg的剂量口服给药,实现了76%的肿瘤生长抑制(TGI=76%)。在VCaP和LNCaP细胞系中对AR-V7和AR-FL的降解效率分别达到77.3%(1 μM)和72.0%(5 μM)。 | |||
T78811 |
PROTAC AR-NTD degrader 1
|
Androgen Receptor | Endocrinology/Hormones |
PROTACAR-NTD antagonist 1 (compound 18) 是一款针对雄激素受体AR-V7变体的PROTACs,它特异性地拮抗AR的N末端结构域 (AR-NTD),能有效诱导前列腺癌细胞凋亡,并在VCaP细胞中以1 μM 和 5 μM的浓度分别实现了62.2%和71.1%的AR-V7蛋白降解率。 | |||
T35897 |
ASK120067
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ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]. In the in vitro kinase assay ASK120067 potently inhibits the EGFR L858R/T790M and EGFR T790M resistant mutants with IC50 values of 0.3 nM and 0.5 nM, respectively, as well as the EGFRexon19del sensitizing mutant (IC50= 0.5 nM). The 50 of ASK120067 against wild-type EGFR (EGFRWT... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T5288 |
Cytidine-5'-triphosphate disodium
胞苷 5'-三磷酸二钠盐,CTP,Cytidine 5'-triphosphate (disodium salt) |
Others; Endogenous Metabolite | Metabolism; Others |
Cytidine-5'-triphosphate disodium (CTP) 是内源性代谢产物的一种。 | |||
T4S2126 |
Ginkgetin
银杏双黄酮,银杏素 |
Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells |
Ginkgetin 是从银杏叶中分离得到的一种双黄酮,具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂,IC50值为 5.92 μM。 | |||
TN3125 |
5-Methoxycanthin-6-one
|
Others | Others |
5-Methoxycanthin-6-one displays moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC50 values ranging from 13.5-15.4 uM versus doxorubicine with IC50 = 1.5 uM. It also exhibits a clear suppressive effect on the phagocytosi | |||
T36791 |
Lysophosphatidylcholine 18:2
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1-Linoleoyl-2-hydroxy-sn-glycero-3-PC (LGPC) is a lysophospholipid containing linoleic acid at thesn-1 position that has been found in mouse heart, lung, liver, spleen, kidney, plasma, and serum.1Serum levels of LGPC decrease with increasing insulin resistance and dysglycemia in humans.2 1.Okudaira, M., Inoue, A., Shuto, A., et al.Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MSJ. Lipid Res.55(10)2178-2192(2014) 2.Gall, ... |