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Search Results for " palb "

Targets Recommended: CDK

12

抑制剂 & 化合物

5

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6239	Palbociclib monohydrochloride PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl	CDK	Cell Cycle/Checkpoint
	Palbociclib monohydrochloride (PD 0332991 hydrochloride) 是一种口服的细胞周期蛋白依赖性激酶 (CDK) 抑制剂，具有潜在的抗肿瘤活性。它抑制 CDK4和 CDK6，IC50分别为11 nM，16 nM。它有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T6240	Palbociclib Isethionate Palbociclib (PD0332991) Isethionate,帕博西尼羟乙基磺酸盐,PD 0332991 isethionate,帕布昔利布羟乙基磺酸盐	CDK	Cell Cycle/Checkpoint
	Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。
T1785	Palbociclib PD 0332991,帕博西尼,帕布昔利布	CDK	Cell Cycle/Checkpoint
	Palbociclib (PD 0332991) 是一种 CDK 抑制剂，抑制 CDK4 和 CDK6 (IC50=11/16 nM)，具有口服活性。Palbociclib 具有抗肿瘤活性，有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T63634	Palbociclib dihydrochloride
	Palbociclib (PD 0332991) dihydrochloride 是口服具有活力的、选择性的 CDK4 (IC50: 11 nM) 和 CDK6 (IC50: 16 nM) 抑制剂。Palbociclib dihydrochloride 对癌细胞具有抗增殖活性，并阻滞细胞周期，能够用于 HR 阳性和 HER2 阴性乳腺癌，以及肝细胞癌的相关研究。
T28291	Palbociclib-Succinic acid Palbociclib-hemi Succinic acid,Palbociclib-Succinate,
	Palbociclib-Succinic acid is a Palbociclib- derivative with a succinic acid linker. The carboxy group of Palbociclib-Succinic acid can be used to conjugate with other molecules such as peptides, proteins, or polymers. Palbociclib-Succinic acid is a useful
T72507	Palbociclib orotate PD 0332991 orotate	CDK	Cell Cycle/Checkpoint
	Palbociclib (PD 0332991) orotate 是一种口服活性的CDK4和CDK6选择性抑制剂，其IC50值分别为11 nM和16 nM。该化合物对癌细胞展示出抗增殖效果，并促使细胞周期处于阻滞状态。该药物适用于HR阳性、HER2阴性乳腺癌以及肝细胞癌的研究。
T63576	Palbociclib hydrochloride
	Palbociclib (PD 0332991) hydrochloride 是一种选择性的、有效的 CDK4 (IC50: 11 nM) 和 CDK6 (IC50: 16 nM)抑制剂。Palbociclib hydrochloride 对癌细胞具有抗增殖作用，并诱导细胞周期阻滞，能够用于 HR 阳性和 HER2 阴性乳腺癌，以及肝细胞癌的相关研究。
T78130	N-Methyl Palbociclib	Drug Metabolite	Metabolism
	N-MethylPalbociclib是一种Palbociclib的杂质。Palbociclib（PD 0332991）是一种口服活性的CDK4和CDK6抑制剂。
T12355	Palbociclib-d8 PD 0332991 D8,Palbociclib D8	CDK	Cell Cycle/Checkpoint
	Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively).
T64486	6-Desacetyl Palbociclib
	6-Desacetyl Palbociclib 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64486。
T33865	Palbociclib-SMCC PD0332991-SMCC,Palbociclib-SMCC linker,PD 0332991-SMCC,PD-0332991-SMCC
	Palbociclib-SMCC is a Palbociclib derivative with a SMCC linker.
T18515	Palbociclib-propargyl PROTAC CDK6 ligand 1	Others	Others
	Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent DC50 value of 2.1 nM against CDK6[1].

化合物

Palbociclib monohydrochloride

Cat.No: T6239

Synonym: PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl

Target: CDK

Palbociclib Isethionate

Cat.No: T6240

Synonym: Palbociclib (PD0332991) Isethionate,帕博西尼羟乙基磺酸盐,PD 0332991 isethionate,帕布昔利布羟乙基磺酸盐

Target: CDK

Cat.No: T1785

Synonym: PD 0332991,帕博西尼,帕布昔利布

Target: CDK

Palbociclib dihydrochloride

Cat.No: T63634

Palbociclib-Succinic acid

Cat.No: T28291

Synonym: Palbociclib-hemi Succinic acid,Palbociclib-Succinate,

Palbociclib orotate

Cat.No: T72507

Synonym: PD 0332991 orotate

Target: CDK

Palbociclib hydrochloride

Cat.No: T63576

N-Methyl Palbociclib

Cat.No: T78130

Target: Drug Metabolite

Palbociclib-d8

Cat.No: T12355

Synonym: PD 0332991 D8,Palbociclib D8

Target: CDK

6-Desacetyl Palbociclib

Cat.No: T64486

Palbociclib-SMCC

Cat.No: T33865

Synonym: PD0332991-SMCC,Palbociclib-SMCC linker,PD 0332991-SMCC,PD-0332991-SMCC

Palbociclib-propargyl

Cat.No: T18515

Synonym: PROTAC CDK6 ligand 1

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1889	Lupalbigenin	ERK; Akt; Topoisomerase	Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; PI3K/Akt/mTOR signaling
	Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
TN4308	Isolupalbigenin	Antifection	Microbiology/Virology
	Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also shows in vitro inhibitory activity toward human glyoxalase I. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection.
T82054	Ipalbine
	Ipalbine为源自Ipomoea alba L的六氢吲哚生物碱类化合物。
T12353	Palbinone	Others	Others
	Palbinone is a terpenoid isolated from the roots of Paeonia albiflora Pallas, with anti-inflammatory activity.
T82055	Ipalbidine
	Ipalbidine为自ipomoea Hardwickii Hemsl中提炼的生物碱，显示出剂量依赖性镇痛效果。

天然产物

Cat.No: TN1889

Target: ERK, Akt, Topoisomerase

Isolupalbigenin

Cat.No: TN4308

Target: Antifection

Cat.No: T82054

Cat.No: T12353

Target: Others

Cat.No: T82055

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01756	Transthyretin Protein, Human, Recombinant (His) PALB,HEL111,CTS,transthyretin,CTS1,HsT2651,TBPA	Human	HEK293 Cells
	Transthyretin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is E9KL36.
TMPK-01090	Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His) Prealbumin,TBPA,CTS,HEL111,Transthyretin,TTR,ATTR,CTS1,HsT26...	Cynomolgus	HEK293 Cells
	Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other functions have emerged, namely in the nervous system. TTR aggregates are responsible for many amyloidosis such as familial amyloidotic polyneuropathy and cardiomyopathy. Normal TTR can also aggregate and deposit in the heart of old people and in preeclampsia placental tissue.
TMPY-00261	Meprin beta Protein, Human, Recombinant (His) meprin A, β,Meprin β,meprin A, beta	Human	HEK293 Cells
	MEP1B (Meprin A Subunit Beta) is a Protein Coding gene. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in the kidney and intestine. Meprins are cell membrane, oligomeric metalloendopeptidases composed of two distinct but evolutionarily related subunits, alpha, and beta. MEP1A is mapped to the short arm of chromosome 6 by the use of radiation and som...

重组蛋白

Transthyretin Protein, Human, Recombinant (His)

Cat.No: TMPY-01756

Species: Human

Expression System: HEK293 Cells

Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01090

Species: Cynomolgus

Expression System: HEK293 Cells

Meprin beta Protein, Human, Recombinant (His)

Cat.No: TMPY-00261

Species: Human

Expression System: HEK293 Cells

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