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17

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35695	Oleic Acid-13C
	Oleic acid-13C is intended for use as an internal standard for the quantification of oleic acid by GC- or LC-MS. Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue.1,2 It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.1 Oleic acid inhibits collagen-stimulated platelet aggregation by approximate...
T35603	Oleic Acid-2,6-diisopropylanilide
	AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC50 of 7 nM. When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%.
T1869	PluriSIn 1 4-吡啶羧酸 2-苯基酰肼,NSC 14613,PluriSIn #1,PluriSln 1	Apoptosis; Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Apoptosis; Metabolism
	PluriSIn 1 (NSC 14613) 是一种酰基-辅酶 A 去饱和酶抑制剂，是一种多能细胞特异性的抑制剂。
T2351L	TAK-875 Hemihydrate TAK-875,Fasiglifam	GPR	Endocrinology/Hormones; GPCR/G Protein
	TAK-875 Hemihydrate (Fasiglifam) 是一种选择性 GPR40 激动剂，EC50 为 14 nM，比油酸强 400 倍。
T38216	1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol
	1-Palmitoyl-2-oleoyl-3-arachidonoyl-rac-glycerol is a triacylglycerol that contains palmitic acid , oleic acid , and arachidonic acid at the sn-1, sn-2, and sn-3 positions, respectively. It has been found in lipid extracts from whole rat retina.1
T78511	Oleoyl coenzyme A lithium Oleoyl-CoA lithium
	Oleoyl-CoA lithium是一种由油酸与辅酶A形成的硫酯，它是大肠杆菌和小鼠代谢产物。
T36003	1(R)-(Trifluoromethyl)oleyl alcohol
	1(R)-(Trifluoromethyl)oleyl alcohol is an analog of oleic acid .1It inhibits ferroptosis induced by erastin in primary fibroblasts isolated from patients with Friedreich ataxia, a neuro- and cardiodegenerative disorder characterized by loss or impaired activity of frataxin (FXN), when used at concentrations of 5, 10, or 20 μM. 1(R)-(Trifluoromethyl)oleyl alcohol (5 μM) reduces lipid peroxidation induced byFXNsiRNA knockdown in NBT human myoblasts. 1.Cotticelli, M.G., Forestieri, R., Xia, S., et ...
T38358	1,3-Distearoyl-2-Oleoyl-rac-glycerol
	1,3-Distearoyl-2-oleoyl-rac-glycerol is a triacylglycerol that contains stearic acid at the sn-1 and sn-3 positions and oleic acid at the sn-2 position. It has been found in Kpangnana, Chinese tallow, and cocoa butters. 1,3-Distearoyl-2-oleoyl-rac-glycerol increases the phagocytic function of reticulo-endothelial cells in mice when administered at doses of 5 and 10 mg per animal.
T36005	1-Oleoyl-2-Palmitoyl-rac-glycerol
	1-Oleoyl-2-palmitoyl-rac-glycerol (1,2-OP) is a diacylglycerol containing oleic acid at the sn-1 position and palmitic acid at the sn-2 position. It enhances the inhibition of superoxide anion production by cytochalasin B when used at a concentration of 10 μM. The concentration of 1,2-OP decreases from 25.7 to 11.15% during the dry-curing process of Iberian ham.
T36907	1-Oleoyl Lysophosphatidic Acid Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid
	1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase.[1] Hydrolysis of the fatty acid at the sn-2 position by phospholipase A2 (PLA2) yields bioactive LPA. LPA binds to one of five differe...
T36830	9-Nitrooleate
	Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate , cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide. 9-Nitrooleate is one of two regioisomers of nitrooleate, the other being 10-nitrooleate (OA-NO2; used for the mixture of isomers), which are formed by nitration of oleic acid in a...
T35443	1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol
	1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol is a triacylglycerol that contains palmitic , stearic , and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively. It has been detected in RAW 264.7 cells by neutral loss MS. Increased serum levels of 1-palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol are a potential biomarker for non-alcoholic fatty liver disease (NAFLD).
T36431	7,10-dihydroxy-8(E)-Octadecenoic Acid
	7,10-dihydroxy-8(E)-Octadecenoic acid is a hydroxy fatty acid and metabolite of oleic acid that is produced byP. aeruginosafrom vegetable oils.1It is active against the food-borne pathogenic bacteriaS. aureus,S. typhimurium,L. monocytogenes,B. subtilis, andE. coli(MIC50s = 31.3, 125, 125, 62.5, and 250 μg/ml, respectively), as well as the plant pathogenic bacteriaErwinia,R. solanacearum,C. glutamicum, andP. syringae(MIC90s = 125, 125, 250, and 500 μg/ml, respectively).2,1 1.Sohn, H.-R., Bae, J.-...
T35445	1-Stearoyl-3-Oleoyl-rac-glycerol
	1-Stearoyl-3-oleoyl-rac-glycerol is a diacylglycerol that contains stearic acid at the sn-1 position and oleic acid at the sn-3 position. Intermittent fasting decreases skeletal muscle and hepatic levels of 1-stearoyl-3-oleoyl-rac-glycerol in New Zealand obese (NZO) mice.1 The concentration of 1-stearoyl-3-oleoyl-rac-glycerol decreases from 4.59 to 1.88% during the dry-curing process of Iberian ham.2References1. Baumeier, C., Kaiser, D., Heeren, J., et al. Caloric restriction and intermittent fa...
T36590	9-PAHSA
	Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to a hydroxylated C-16 or C-18 lipid. 9-PAHSA is a FAHFA in which palmitic acid is esterified to 9-hydroxy stearic acid. PAHSAs are the most abundant forms of FAHFA in serum as well as whi...
T37044	1,2-Dioleoyl-rac-glycerol-13C3 1,2-Dioleoyl-rac-glycerol-13C3
	1,2-Dioleoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2-dioleoyl-rac-glycerol by GC- or LC-MS. 1,2-dioleoyl-rac-glycerol is a diacylglycerol that contains oleic acid at the sn-1 and sn-2 positions. It effectively binds the C1 domain to activate conventional protein kinase C forms and serves as a substrate for diacylglycerol kinases and multisubstrate lipid kinase.1,2,3 \|1. Yamaguchi, Y., Shirai, Y., Matsubara, T., et al. Phosphorylation and up-reg...
T36586	12-PAHSA
	Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to either a C-16 or C-18 hydroxy substituent. 12-PAHSA is a FAHFA in which palmitic acid is esterified at the 12th carbon of hydroxy stearic acid. Among the FAHFA family members, PAHSAs ar...

化合物

Oleic Acid-13C

Cat.No: T35695

Oleic Acid-2,6-diisopropylanilide

Cat.No: T35603

Cat.No: T1869

Synonym: 4-吡啶羧酸 2-苯基酰肼,NSC 14613,PluriSIn #1,PluriSln 1

Target: Apoptosis, Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

TAK-875 Hemihydrate

Cat.No: T2351L

Synonym: TAK-875,Fasiglifam

Target: GPR

1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol

Cat.No: T38216

Oleoyl coenzyme A lithium

Cat.No: T78511

Synonym: Oleoyl-CoA lithium

1(R)-(Trifluoromethyl)oleyl alcohol

Cat.No: T36003

1,3-Distearoyl-2-Oleoyl-rac-glycerol

Cat.No: T38358

1-Oleoyl-2-Palmitoyl-rac-glycerol

Cat.No: T36005

1-Oleoyl Lysophosphatidic Acid

Cat.No: T36907

Synonym: Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid

Cat.No: T36830

1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol

Cat.No: T35443

7,10-dihydroxy-8(E)-Octadecenoic Acid

Cat.No: T36431

1-Stearoyl-3-Oleoyl-rac-glycerol

Cat.No: T35445

Cat.No: T36590

1,2-Dioleoyl-rac-glycerol-13C3

Cat.No: T37044

Synonym: 1,2-Dioleoyl-rac-glycerol-13C3

Cat.No: T36586

Cat. No.	Product Name	Target	Signaling Pathways
T2O2668	Oleic acid Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid,油酸	Apoptosis; ATPase; Others; Endogenous Metabolite	Apoptosis; Membrane transporter/Ion channel; Metabolism; Others
	Oleic acid (Glycon Wo) 属于天然产物，是一种常见的饱和脂肪酸，在存在于多种动物、植物的脂肪和油脂中。Palmitic acid 是一种 Na+/K+ATP 酶激活剂。
T13802	Oleamide Oleic acid amide	Others; Endogenous Metabolite	Metabolism; Others
	Oleamide (Oleic acid amide) 是一种内源性脂肪酸酰胺，可用于哺乳动物神经系统的从头合成。
T4740	Elaidic acid 反油酸,trans-Oleic Acid	Endogenous Metabolite	Metabolism
	Elaidic acid (trans-Oleic Acid) 是在氢化植物油中发现的主要反式脂肪，能够被用作药物溶剂。在与花生四烯酸孵育的人类血小板中，反油酸抑制 HHT 和 HETE 的形成，同时诱导前列腺素和血栓素的合成。
T36390	Sodium oleate Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt	ATPase	Membrane transporter/Ion channel
	Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) 是人脂肪细胞和其他组织中最常见的单不饱和脂肪酸钠盐。Sodium oleate 是一种 Na+/K+ ATP 酶激活剂。
T12296	Oleoylethanolamide 油酰单乙醇胺,N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide	Endogenous Metabolite; PPAR	DNA Damage/DNA Repair; Metabolism
	Oleoylethanolamide (N-Oleoylethanolamide) 是一种PPAR-α 的高亲和力内源性激动剂，可用于肥胖和动脉硬化的相关研究。
T2O2667	Methyl Oleate 油酸甲酯,oleic acid methyl ester,Methyl cis-9-Octadecenoate,cis-9-Octadecenoic Acid methyl ester	Others	Others
	Methyl Oleate (cis-9-Octadecenoic Acid methyl ester) 是脂肪酸甲酯。它能够显著提高抗氧化能力，但也明显削弱二烷基二硫代磷酸锌的抗磨能力。
T16075	(Rac)-Idroxioleic acid 2-Hydroxyoleic acid,2-OHOA,2-羟基乳清酸,Minerval	Apoptosis	Apoptosis
	(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) 是一种具有抗肿瘤作用的脂肪酸酰胺水解酶抑制剂。它与质膜结合并改变脂质组织。
T13616	cis-9,10-Epoxystearic acid cis-9,10-Epoxystearic acid,cis-9,10-Epoxyoctadecanoic acid	Endogenous Metabolite	Metabolism
	cis-9,10-Epoxystearic acid (cis-9,10-Epoxyoctadecanoic acid) 是来自人血液和尿液的内源性成分。它可以通过油酸和非酶环氧化反应从油酸中制备。
T4943	Monoolein 1-Oleoyl-rac-glycerol,甘油单油酸酯	Others; Endogenous Metabolite	Metabolism; Others
	Monoolein (1-Oleoyl-rac-glycerol) 是内源性代谢产物的一种。
T4734	Suberic acid Octanedioic acid,1,8-Octanedioic acid,辛二酸	Others; Endogenous Metabolite	Metabolism; Others
	Suberic acid (1,8-Octanedioic acid) 被发现和肉毒碱-甲酰基-丙氨酸转位酶缺乏(丙二醇-羧基酶缺乏症)有关。
T8011	1,2-dioleoyl-sn-glycero-3-phosphocholine 二油酰磷脂酰胆碱,DOPC	Others	Others
	1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) 是磷脂的一种，在胶束，脂质体和其他类型的人工膜的生成中通常单独使用或与其他组分一起使用。
T19316	Ethyl oleate	Others	Others
	Ethyl oleate 是由油酸和乙醇的缩合形成的脂肪酸酯。它是纳米结构脂质载体 (NLC) 中的液体脂质成分。其中 NLC 是一种口服有活性的反式阿魏酸的给药载体。
T0926	Azelaic acid Finacea,Azelex,壬二酸,Nonanedioic acid,Anchoic acid	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	Azelaic acid (Anchoic acid) 是头发和皮肤调理剂的组分，可由油酸臭氧分解产生。Azelaic acid 通过抑制微生物细胞原蛋白合成对痤疮丙酸杆菌和表皮葡萄球菌具有抑菌活性。Azelaic acid 还具有抑制色素沉着的功能，这是由于其清除自由基作用。
T74236	1-Oleoyl-2-palmitoyl-sn-glycero-3-PC
	1-Oleoyl-2-palmitoyl-sn-glycero-3-PC，由油酸衍生，用于脂质体合成。
T38596	9,10-Dihydroxystearic acid
	9,10-Dihydroxystearic acid, an oxidation derivative of oleic acid, exhibits beneficial effects on glucose tolerance and insulin sensitivity in KKAy mice.
T40910	Cognac oil
	Cognac oil, predominantly derived from wine lees, exhibits distinctive fatty acid compositions, characterized by high proportions of Palmitic acid (59.26%), Linoleic acid (11.92%), Myristic acid (8.97%), and Oleic acid (8.3%) among other fatty acids. Notably, the application of Cognac oil enhances the permeability of Rhodamine 6G (R6G) across various membranes, resulting in a generalized increase in permeation.
T37884	1,3-Linolein-2-Olein
	1,3-Dilinoleoyl-2-oleoyl-rac-glycerol is a triacylglycerol that contains linoleic acid at the sn-1 and sn-3 positions and oleic acid at the sn-2 position. It has been found in grape seed, pumpkin seed, soybean, sunflower, and wheat germ oils, with the highest content in grape seed oil.

天然产物

Cat.No: T2O2668

Synonym: Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid,油酸

Target: Apoptosis, ATPase, Others, Endogenous Metabolite

Cat.No: T13802

Synonym: Oleic acid amide

Target: Others, Endogenous Metabolite

Cat.No: T4740

Synonym: 反油酸,trans-Oleic Acid

Target: Endogenous Metabolite

Cat.No: T36390

Synonym: Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt

Target: ATPase

Oleoylethanolamide

Cat.No: T12296

Synonym: 油酰单乙醇胺,N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide

Target: Endogenous Metabolite, PPAR

Cat.No: T2O2667

Synonym: 油酸甲酯,oleic acid methyl ester,Methyl cis-9-Octadecenoate,cis-9-Octadecenoic Acid methyl ester

Target: Others

(Rac)-Idroxioleic acid

Cat.No: T16075

Synonym: 2-Hydroxyoleic acid,2-OHOA,2-羟基乳清酸,Minerval

Target: Apoptosis

cis-9,10-Epoxystearic acid

Cat.No: T13616

Synonym: cis-9,10-Epoxystearic acid,cis-9,10-Epoxyoctadecanoic acid

Target: Endogenous Metabolite

Cat.No: T4943

Synonym: 1-Oleoyl-rac-glycerol,甘油单油酸酯

Target: Others, Endogenous Metabolite

Cat.No: T4734

Synonym: Octanedioic acid,1,8-Octanedioic acid,辛二酸

Target: Others, Endogenous Metabolite

1,2-dioleoyl-sn-glycero-3-phosphocholine

Cat.No: T8011

Synonym: 二油酰磷脂酰胆碱,DOPC

Target: Others

Cat.No: T19316

Target: Others

Cat.No: T0926

Synonym: Finacea,Azelex,壬二酸,Nonanedioic acid,Anchoic acid

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

1-Oleoyl-2-palmitoyl-sn-glycero-3-PC

Cat.No: T74236

9,10-Dihydroxystearic acid

Cat.No: T38596

Cat.No: T40910

1,3-Linolein-2-Olein

Cat.No: T37884

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