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Search Results for " osf "

Targets Recommended: DNA Alkylator/Crosslinker DNA/RNA Synthesis

25

抑制剂 & 化合物

6

天然产物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1055	Ifosfamide NSC109724,Isophosphamide,异环磷酰胺	DNA Alkylator/Crosslinker; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Ifosfamide (NSC-109724) 是一种烷化剂，具有抗肿瘤活性。它烷基化并形成 DNA 交联，从而防止 DNA 链分离和 DNA 复制。它是一种前药，必须通过肝微粒体酶的羟基化来激活。
T4989	Fosfomycin Tromethamine	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin tromethamine 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药细菌。
T5328	Fosfluconazole	Antifungal	Microbiology/Virology
	Fosfluconazole 是 fluconazole 的水溶性磷酸盐前药。它是一种抗真菌药物。
T15390	Glufosfamide D 19575,Glucosylifosfamide mustard	Others	Others
	Glufosfamide 是一种新型噁唑磷胺化合物，具有抗癌活性，可用于研究晚期非小细胞肺癌。
T3131	Fosfomycin calcium Phosphomycin calcium salt,Fosmicin,磷霉素钙	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin calcium (Phosphomycin calcium salt) 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药细菌。
T17172	Trofosfamide	Antibacterial	Microbiology/Virology
	Trofosfamide 是一种具有抗肿瘤效力的恶氮膦衍生物。
T3615	Evofosfamide 艾伏磷酰胺,TH-302	Apoptosis; Others	Apoptosis; Others
	Evofosfamide (TH-302) 是一种缺氧激活前药，在缺氧 (N2) 和常氧 (21% O2) 环境下，IC50分别为 10 μM 和 1000 μM。
T4350	Palifosfamide ZIO-201,Isophosphamide mustard,帕利伐米,Isophosphoramide mustard	DNA Alkylator/Crosslinker; DNA Alkylation; Drug Metabolite	DNA Damage/DNA Repair; Metabolism
	Palifosfamide (Isophosphamide mustard) 是一种新 DNA 烷化剂，是异环磷酰胺的活性代谢物，。它在体外肉瘤细胞系中具有广泛的活性，具有抗癌活性。
T77150	Cosfroviximab
	Cosfroviximab(c13C6-FR1)是一种抗埃博拉病毒糖蛋白(EBOV-GP)的鼠/人嵌合单克隆抗体。
T27349	Fosfluridine tidoxil HDP 990006,HDP990006,HDP-990006
	Fosfluridine tidoxil, a thymidylate synthase inhibitor, is used potentially for the treatment of colorectal cancer, and breast cancer.
T68592	Mafosfamide sodium
	Mafosfamide sodium is a synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide sodium alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, Mafosfamide sodium, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, Mafosfamide sodium is potentially useful in the intrathecal treatment of neoplastic meningitis.
T68434	Mafosfamide
	Mafosfamide is a synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis.
T71500	Palifosfamide tromethamine IPM tromethamine,Isophosphoramide mustard tromethamine,ZIO-201 tromethamine,Isophosphoramide mustard tromethamine ; IPM tromethamine ; ZIO-201 tromethamine
	Palifosfamide (tromethamine) 是一种具有潜在抗肿瘤活性的合成烷基化剂。作为异环磷酰胺 (ifosfamide) 稳定的活性代谢物，Palifosfamide (tromethamine) 通过GC 碱基对不可逆地烷基化和交联DNA，导致了DNA 复制的抑制，并导致细胞死亡。与异环磷酰胺相比，Palifosfamide (tromethamine)的毒性较小。
T75245	Canfosfamide
	Canfosfamide (TLK-286) 是一种谷胱甘肽类似物前体药物，由谷胱甘肽 S-转移酶 P1-1 激活，诱导细胞凋亡 (apoptosis)。Canfosfamide 还抑制 DNA 依赖性蛋白激酶 (DNA-PK) 的催化激酶活性。Canfosfamide 在活化后产生一种抗癌烷基化剂和谷胱甘肽衍生物。Canfosfamide 可用于恶性肿瘤的研究。
T83317	4-Hydroperoxyifosfamide
	4-Hydroperoxyifosfamide是一种能穿透血脑屏障的抗癌化合物。
T37849	Butafosfan
	Butafosfan is an organic phosphorus supplement that is given, most commonly with cyanocobalamin, to cattle, swine, horses, and poultry for the prevention or treatment of deficiencies. When given with cyanocobalamin, butafosfan alters lipid metabolism, serving to decrease the prevalence of subclinical ketosis.
T21306	Glyfosfin
	Glyfosfin is a DNA cross-linking agent and an alkylating agent with anticancer activity.
T67975	canfosfamide hydrochloride
	Canfosfamide Hydrochloride 是一种改性谷胱甘肽类似物的盐酸盐，具有潜在的抗肿瘤活性。canfofamide 可被谷胱甘肽s -转移酶P1-1选择性激活，转化为与肿瘤细胞DNA 亲核中心形成共价键的烷基化代谢物，从而诱导细胞应激反应和细胞毒性，减少肿瘤增殖。
T29851	Aldoifosfamide UNII-S1JX147O5E,Mitoxana,Ifex
	Aldoifosfamide is a metabolite of ifosfamide. Ifosfamide (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer. It is sometimes abbreviated 'IFO''.
T25021	Alafosfalin Alaphosphin
	Alafosfalin is a Chemotherapeutic agent.
T68614	Doxycycline fosfatex
	Doxycycline is a synthetic tetracycline derivative with similar antimicrobial activity. Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Doxycycline has bacteriostatic activity against a broad range of Gram-positive and Gramnegative bacteria. Doxycycline has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections.
T25723	L-Ifosfamide (+)-Ifosfamide
	L-Ifosfamide is nitrogen mustard, a chemotherapeutic antineoplastic, and more precisely an alkylating agent structural analog of cyclophosphamide with respect to which presents some differences regard to the antitumor activity and spectrum.
T30319	Benfosformin Benfosformine,JAV-52,JAV852,JAV 852,Benfosformina
	Benfosformin is a bioactive chemical.
T69345	Fosfonet sodium
	Fosfonet sodium is a sodium salt formulation of phosphonoacetic acid with activity against herpes simplex viruses and other members of the herpes virus family. Fosfonet inhibits viral DNA polymerase and inhibits the synthesis of viral DNA.
T20706	Fosfomycin Antibiotic 833A,MK-955,Fosfonomycin,MK955,MK 955
	Fosfomycin is an antibiotic that is produced by Streptomyces fradiae.

化合物

Cat.No: T1055

Synonym: NSC109724,Isophosphamide,异环磷酰胺

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis

Fosfomycin Tromethamine

Cat.No: T4989

Target: Antibacterial, Antibiotic

Cat.No: T5328

Target: Antifungal

Cat.No: T15390

Synonym: D 19575,Glucosylifosfamide mustard

Target: Others

Fosfomycin calcium

Cat.No: T3131

Synonym: Phosphomycin calcium salt,Fosmicin,磷霉素钙

Target: Antibacterial, Antibiotic

Cat.No: T17172

Target: Antibacterial

Cat.No: T3615

Synonym: 艾伏磷酰胺,TH-302

Target: Apoptosis, Others

Cat.No: T4350

Synonym: ZIO-201,Isophosphamide mustard,帕利伐米,Isophosphoramide mustard

Target: DNA Alkylator/Crosslinker, DNA Alkylation, Drug Metabolite

Cat.No: T77150

Fosfluridine tidoxil

Cat.No: T27349

Synonym: HDP 990006,HDP990006,HDP-990006

Mafosfamide sodium

Cat.No: T68592

Cat.No: T68434

Palifosfamide tromethamine

Cat.No: T71500

Synonym: IPM tromethamine,Isophosphoramide mustard tromethamine,ZIO-201 tromethamine,Isophosphoramide mustard tromethamine ; IPM tromethamine ; ZIO-201 tromethamine

Cat.No: T75245

4-Hydroperoxyifosfamide

Cat.No: T83317

Cat.No: T37849

Cat.No: T21306

canfosfamide hydrochloride

Cat.No: T67975

Cat.No: T29851

Synonym: UNII-S1JX147O5E,Mitoxana,Ifex

Cat.No: T25021

Synonym: Alaphosphin

Doxycycline fosfatex

Cat.No: T68614

Cat.No: T25723

Synonym: (+)-Ifosfamide

Cat.No: T30319

Synonym: Benfosformine,JAV-52,JAV852,JAV 852,Benfosformina

Fosfonet sodium

Cat.No: T69345

Cat.No: T20706

Synonym: Antibiotic 833A,MK-955,Fosfonomycin,MK955,MK 955

Cat. No.	Product Name	Target	Signaling Pathways
T8074	Esafosfan trisodium Fosfructose trisodium,D-果糖-1,6-二磷酸三钠盐,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium	Others; Endogenous Metabolite	Metabolism; Others
	Esafosfan trisodium (FDP trisodium) 是一种细胞保护性的天然糖磷酸盐，用于镰状细胞性贫血，心血管缺血和哮喘的研究。Fosfructose trisodium 通过刺激无氧糖酵解起作用，其在缺血条件下产生三磷酸腺苷。
T3228	Fosfructose D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,二磷酸果糖,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan	Others; Endogenous Metabolite	Metabolism; Others
	D-fructose-1,6-diphosphate 是一种细胞保护性的天然糖磷酸盐，Fosfructose 通过刺激无氧糖酵解起作用，其在缺血条件下产生三磷酸腺苷,有潜力用于心血管缺血，镰状细胞性贫血和哮喘的研究。
T8262	Fosfomycin sodium Fosfomycin Disodium,磷霉素钠	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin sodium 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药的细菌。
T40472	Gosferol
	Gosferol is a furocoumarin from the roots of Prangos ferulacea.
TN4295	Isogosferol	Others	Others
	Isogosferol is a minor furocoumarin of Murraya koenigii seeds.
T37984	Fosfructose, sodium salt, hydrate (1:3:8) D-Fructose-1,6-bisphosphate , sodium salt, hydrate (1:3:8)	Others	Others
	D-Fructose-1,6-bisphosphate sodium salt hydrate 是碳水化合物代谢的中间体，包括糖酵解和糖异生。在糖酵解过程中，它是由磷酸果糖激酶磷酸化果糖-6-磷酸产生的。由果糖-1,6-二磷酸酶-1介导的逆反应是糖异生的限速步骤之一。同样的反应也发生在植物的叶绿体中，D-Fructose-1,6-bisphosphate sodium salt hydrate 作为还原性戊糖磷酸循环的一部分。由于癌细胞采用糖酵解作为代谢能量产生的主要来源，这一途径已成为癌症化疗的主要靶点。

天然产物

Esafosfan trisodium

Cat.No: T8074

Synonym: Fosfructose trisodium,D-果糖-1,6-二磷酸三钠盐,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium

Target: Others, Endogenous Metabolite

Cat.No: T3228

Synonym: D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,二磷酸果糖,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan

Target: Others, Endogenous Metabolite

Fosfomycin sodium

Cat.No: T8262

Synonym: Fosfomycin Disodium,磷霉素钠

Target: Antibacterial, Antibiotic

Cat.No: T40472

Cat.No: TN4295

Target: Others

Fosfructose, sodium salt, hydrate (1:3:8)

Cat.No: T37984

Synonym: D-Fructose-1,6-bisphosphate , sodium salt, hydrate (1:3:8)

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01020	Periostin/OSF-2 Protein, Human, Recombinant (His) PN,OSF-2,OSF2,periostin,periostin, osteobl...	Human	HEK293 Cells
	Periostin/OSF-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession number is Q15063-3.
TMPY-01613	Periostin/OSF-2 Protein, Mouse, Recombinant (His) A630052E07Rik,OSF-2,Osf2,PLF,AI747096,peri...	Mouse	HEK293 Cells
	Periostin/OSF-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 89 kDa and the accession number is Q62009-2.
TMPY-03577	Pleiotrophin/PTN Protein, Mouse, Recombinant HBGF-8,HBBN,HBNF,HB-GAM,pleiotrophin,Osf-1,Osf<...	Mouse	Baculovirus Insect Cells
	Pleiotrophin/PTN Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 15.3 kDa and the accession number is P63089.
TMPK-00973	Periostin/OSF-2 Protein, Human, Recombinant (aa 22-836, His) Periostin,POSTN,Fasciclin I-like,TRIF52,OSF-2,PNRP1...	Human	HEK293 Cells
	Periostin/OSF-2 Protein, Human, Recombinant (aa 22-836, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 92.1 kDa and the accession number is Q15063.
TMPK-01032	Periostin/OSF-2 Protein, Mouse, Recombinant (aa 24-811, His) POSTN,OSF2,Periostin,TRIF52,PNRP11-412K4.1,PN,Fasci...	Mouse	HEK293 Cells
	Periostin/OSF-2 Protein, Mouse, Recombinant (aa 24-811, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 88.7 kDa and the accession number is Q62009-1.
TMPJ-01266	CDH11 Protein, Human, Recombinant (hFc & His) OSF-4,Osteoblast cadherin,CDH11,Cadherin-11	Human	HEK293 Cells
	Cadherin-11, also known as OSF-4, Osteoblast cadherin and CDH11, is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells, may thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in brain. Mature cadherin proteins consists of a large N-terminal extracellular doma...
TMPY-02850	Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc) Osf-1,HB-GAM,HBGF-8,HBBN,pleiotrophin,OSF,...	Mouse	HEK293 Cells
	Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.7 kDa and the accession number is P63089.
TMPY-02372	Peroxiredoxin 1 Protein, Mouse, Recombinant (His) PAG,OSF-3,OSF3,Paga,PRDX1,Tdpx2,PrxI,TDX2,...	Mouse	E. coli
	Peroxiredoxin 1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.5 kDa and the accession number is P35700.
TMPK-00587	CDH11 Protein, Human, Recombinant (aa 54-617, His) CDH11,Osteoblast cadherin,OSF-4,CAD11OSF-4...	Human	HEK293 Cells
	CDH11 belongs to a group of transmembrane proteins that are principally located in adherens junctions. CDH11 mediates homophilic cell-to-cell adhesion, which may promote the development of cirrhosis. CDH11 expression was positively correlated with liver fibrosis in patients with cirrhosis, and could therefore be a prognostic factor in patients with liver fibrosis.
TMPJ-01051	Pleiotrophin/PTN Protein, Mouse, Recombinant (His) HBGF-8,OSF-1,PTN,HBBM,Pleiotrophin,Heparin-binding ...	Mouse	HEK293 Cells
	Pleiotrophin (PTN) is a secreted, strongly heparinbinding, developmentally regulated cytokine. PTN is a highly conserved protein，Human, mouse, rat, canine, porcine, equine and bovine PTN share 98% aa sequence identity or greater. PTN and midkine share 50% amino acid (aa) sequence identity, share some functions, and constitute a family. During development, PTN is involved in development of brain, bone, and organs undergoing branching morphogenesis. PTN causes PTPRB dimerization and inactivates it...

重组蛋白

Periostin/OSF-2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01020

Species: Human

Expression System: HEK293 Cells

Periostin/OSF-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01613

Species: Mouse

Expression System: HEK293 Cells

Pleiotrophin/PTN Protein, Mouse, Recombinant

Cat.No: TMPY-03577

Species: Mouse

Expression System: Baculovirus Insect Cells

Periostin/OSF-2 Protein, Human, Recombinant (aa 22-836, His)

Cat.No: TMPK-00973

Species: Human

Expression System: HEK293 Cells

Periostin/OSF-2 Protein, Mouse, Recombinant (aa 24-811, His)

Cat.No: TMPK-01032

Species: Mouse

Expression System: HEK293 Cells

CDH11 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-01266

Species: Human

Expression System: HEK293 Cells

Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02850

Species: Mouse

Expression System: HEK293 Cells

Peroxiredoxin 1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02372

Species: Mouse

Expression System: E. coli

CDH11 Protein, Human, Recombinant (aa 54-617, His)

Cat.No: TMPK-00587

Species: Human

Expression System: HEK293 Cells

Pleiotrophin/PTN Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01051

Species: Mouse

Expression System: HEK293 Cells

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